Navigation Links
Shedding light on the 'dark matter' of the genome
Date:11/29/2011

Most of the time, Stefano Torriani is a plant pathologist. His most recent research project revolved around the fungus Mycosphaerella graminicola where he analyzed a special class of genes that encode cell wall degrading enzymes. A virulent fungus relies heavily on these enzymes when attacking a plant. But while investigating these genes, Torriani came across something odd; one gene came in different sizes in different individuals.

To further explore and better understand this phenomenon, the researcher deviated from his original plan and drew in other experts, including Daniel Croll, Patrick Brunner and Eva Stukenbrock from the research group led by Bruce McDonald, Professor of Plant Pathology, ETH Zurich. What they discovered after a year of feverish research throws new light on genome evolution - but still leaves many questions unanswered.

The intron makes the difference

The plant pathologists quickly answered the question of why the same gene came in different lengths in different individuals. In some strains the gene, "ID-60105", which encodes for a cell wall-digesting enzyme, had an intron, in other strains the same gene did not have an intron.

Thus, the researchers stepped into a relatively young field in biology. So-called "spliceosomal introns" were discovered only 30 years ago. Because they are non-coding regions of a gene, they provide no information on the structure of the encoded protein. Introns are separated by the coding regions, called exons. A gene, including both exons and introns, is read by the cellular machinery and transcribed into a messenger RNA. In a next step, the noncoding introns are cut away and the coding exons are spliced together. This creates the blueprint for the corresponding protein encoded by a gene.

Biologists still do not understand the function of introns and why they are present in such large numbers in most eukaryotes, the higher organisms, including humans. Pr
'/>"/>

Contact: Bruce McDonald
bruce.mcdonald@agrl.ethz.ch
41-446-323-847
ETH Zurich/Swiss Federal Institute of Technology
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Foot and mouth disease may spread through shedding skin cells
2. Shedding light on cancer cells
3. New research aims to shed light on how aging affects immunity
4. Smithsonian scientists use fossil feathers reveal lineage of extinct, flightless ibis
5. Genome sequence sheds new light on how plants evolved nitrogen-fixing symbioses
6. Brain, repair thyself: Studies highlight brains resiliency to damage
7. Trees adapt to poor levels of sunlight to effectively process carbon, study shows
8. Wildlife Conservation Society helps scarlet macaws take flight in Guatemala
9. Ecological light scattering film for brand protection, packages and consumer products
10. Mid-ocean creatures control light to avoid becoming snacks
11. ORNL fundamental discovery casts enzymes in new light
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/10/2015)... April 10, 2015 Research and ... the "Security Competitive Profiles - NEC" report ... NEC will continue to supply a range ... market, with a company focus on the development of ... Winning opportunities in the Asia-Pacific ...
(Date:4/2/2015)... HAMBURG, Germany , April 2, 2015 /PRNewswire/ ... ten fingerprint tests DERMALOG by far outperforms the ... While always maintaining high accuracy, the system is ... second. Hence, the speed proves up to be ... 40% faster than its runner-up performance. ...
(Date:4/1/2015)... 2015  NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... the growing mobile commerce market, announces the second shipment ... underway to early access pre-order customers. ... retail outlets including Walmart, Target, AT&T, Dunkin, Donuts, Stop ... accepted at all outlets and very easy to use. ...
Breaking Biology News(10 mins):NEC Security Competitive Profile 2015 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4
... baggage may have helped a tiny fish thrive in ... UBC study published today in Science Express . ... originated in the ocean but began populating freshwater lakes ... past 20,000 years - a relatively short time span ...
... 2008 Presenting new research about national, home and ... a University of Houston professor and his colleagues has ... it comes to surveillance. Two professors ... fifth annual Institute of Electrical and Electronics Engineers International ...
... report reveals surprisingly large populations of two globally ... The report counted 42,000 black-shanked douc langurs along ... Biodiversity Conservation Area, an estimate that represents the ... world. WCS scientists conducted the surveys with the ...
Cached Biology News:'Armored' fish study helps strengthen Darwin's natural selection theory 2National security remedies among topics at surveillance confab 2National security remedies among topics at surveillance confab 3Unexpected large monkey population discovered 2
(Date:5/1/2015)... and RESEARCH TRIANGLE PARK, N.C. , ... ) announced today that Roger Jeffs , Ph.D., President ... overview and update on the company,s business at the Deutsche ... Boston, Massachusetts . The presentation will ... Eastern Time, and can be accessed via a live webcast ...
(Date:4/30/2015)... -- Roka Bioscience, Inc. (NASDAQ: ROKA ), a molecular ... the detection of foodborne pathogens, announced plans to release ... on May 7, 2015 after the close of the ... a conference call at 4:30 p.m. Eastern Time on ... results. During the conference call, material information concerning the ...
(Date:4/30/2015)... (PRWEB) April 30, 2015 Cytokinetics, Incorporated (Nasdaq: ... quarter of 2015 were $4.4 million, compared to $8.0 million ... for the first quarter was $8.9 million, or $0.23 per ... loss for the same period in 2014, of $8.7 million, ... March 31, 2015, cash, cash equivalents and investments totaled $117.5 ...
(Date:4/30/2015)... Nitto Avecia, a leading biotechnology manufacturer ... and production capability to serve biotechnology pharmaceutical clients. ... fulfillment continues to drive Nitto Avecia to enhance ... , In Fall 2014, Nitto Avecia ... at its Milford, MA facility, which is recognized ...
Breaking Biology Technology:Roka Bioscience to Report First Quarter 2015 Financial Results On May 7, 2015 2Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 2Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 3Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 4Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 5Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 6Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 7Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 8Biotechnology Manufacturer Nitto Avecia Expands Capacity to Meet Client Demand 2
... from around the world will present the latest breakthroughs ... at the 2008 Conference on Lasers and Electro-Optics/Quantum Electronics ... the San Jose McEnery Convention Center in San Jose, ... those in the lasers and electro-optics community. It will ...
... could be reduced by application of a simple polymer, ... injected into the blood stream as reported in ... , Andrew Koob and Richard Borgens from Purdue University, ... was effective in limiting damage if administered within four ...
... - Dragon Pharmaceutical Inc.,("Dragon Pharma" or the "Company" ... pharmaceutical company, today announced the results,of the Annual ... Shenzhen,China., There were 48,663,865 shares equaling 69.81% ... shareholders re-elected the following,eight persons to serve as ...
Cached Biology Technology:Detecting dangerous chemicals with lasers, exploring the brain's circuitry with light and more 2Detecting dangerous chemicals with lasers, exploring the brain's circuitry with light and more 3Detecting dangerous chemicals with lasers, exploring the brain's circuitry with light and more 4Detecting dangerous chemicals with lasers, exploring the brain's circuitry with light and more 5Detecting dangerous chemicals with lasers, exploring the brain's circuitry with light and more 6Detecting dangerous chemicals with lasers, exploring the brain's circuitry with light and more 7
... is for when you need to make your ... transformation efficiency. Our services for preparing competent cells ... MCLab's custom competent cell service offers: ... Fast turnaround Quality control performance ...
SHEEP ANTI BOVINE LACTOPEROXIDASE...
FRACTALKINE [Human] (Recombinant)...
Growth Medium / Media...
Biology Products: