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Shedding light on a gene mutation that causes signs of premature aging
Date:4/8/2013

, resulting in systemic defects similar to those seen in aging."

The researchers say the lack of ATRX in the anterior pituitary caused problems with the thyroid, resulting in low levels of a hormone called insulin-like growth factor-one (IGF-1) in the blood. There are theories that low IGF-1 can deplete stores of stem cells in the body, and Brub says that's one of the explanations for the premature aging. This research was funded by the Canadian Institutes of Health Research.


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Contact: Kathy Wallis
kwallis3@uwo.ca
519-661-2111 x81136
University of Western Ontario
Source:Eurekalert

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