Navigation Links
Sharper, deeper, faster
Date:7/25/2011

PASADENA, Calif. For modern biologists, the ability to capture high-quality, three-dimensional (3D) images of living tissues or organisms over time is necessary to answer problems in areas ranging from genomics to neurobiology and developmental biology. The better the image, the more detailed the information that can be drawn from it. Looking to improve upon current methods of imaging, researchers from the California Institute of Technology (Caltech) have developed a novel approach that could redefine optical imaging of live biological samples by simultaneously achieving high resolution, high penetration depth (for seeing deep inside 3D samples), and high imaging speed.

The imaging technique is explained in a paper in the advance online publication of the journal Nature Methods, released on July 14. It will also appear in an upcoming print version of the journal.

"Before our work, the state-of-the-art imaging techniques typically excelled in only one of three key parameters: resolution, depth, or speed. With our technique, it's possible to do well in all three and, critically, without killing, damaging, or adversely affecting the live biological samples," says biologist Scott Fraser, director of the Biological Imaging Center at Caltech's Beckman Institute and senior author of the study.

The research team achieved this imaging hat trick by first employing an unconventional imaging method called light-sheet microscopy, where a thin, flat sheet of light is used to illuminate a biological sample from the side, creating a single illuminated optical section through the sample. The light given off by the sample is then captured with a camera oriented perpendicularly to the light sheet, harvesting data from the entire illuminated plane at once. This allows millions of image pixels to be captured simultaneously, reducing the light intensity that needs to be used for each pixel. This not only enables fast imaging speed but also de
'/>"/>

Contact: Deborah Williams-Hedges
debwms@caltech.edu
626-395-3227
California Institute of Technology
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. UBC megapixel DNA replication technology promises faster, more precise diagnostics
2. Faster 3-D nanoimaging a possibility with full color synchrotron light
3. Again, but faster! The spectacular courtship dance of a tiny bird
4. Evolution drives many plants and animals to be bigger, faster
5. Operation makes dementia patients faster and smarter
6. Faster development might have its costs
7. Study finds fisheries management makes coral reefs grow faster
8. Major advance in MRI allows much faster brain scans
9. MGH researchers develop faster method of engineering zinc-finger nucleases
10. Faster water flow means greater diversity of invertebrate marine life
11. This faster-growing E. coli strains a good thing
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Sharper, deeper, faster
(Date:9/16/2014)... Each tree species has its own bacterial identity. That,s ... from other institutions who studied the genetic fingerprints of ... Panamanian island. , "This study demonstrates for the first ... with different ecological strategies possess very different microbial communities ... a former postdoctoral researcher in the UO,s Institute of ...
(Date:9/16/2014)... chunk of rock hit the Yukatan peninsula near the site ... 100 teratons of TNT. It left a crater more than ... and volcanism are widely accepted to have wiped out the ... But what happened to the plants on which the dinosaurs ... University of Arizona reveals that the meteorite impact that spelled ...
(Date:9/16/2014)... complex web of interaction between viruses, bacteria, and ... a growing international collaboration between Matthew Sullivan, associate ... Ecology and Evolutionary Biology and Steven Hallam from ... , "Bacteria are drivers of nutrient and ... "As the climate is changing, so are the ...
Breaking Biology News(10 mins):Microbiome research shows each tree species has a unique bacterial identity 2Meteorite that doomed the dinosaurs helped the forests bloom 2Meteorite that doomed the dinosaurs helped the forests bloom 3New research decodes virus-host interactions in ocean dead zones 2New research decodes virus-host interactions in ocean dead zones 3
... small number of households could go a long way to ... measured differences in energy demands at the household level, appears ... Dominik Saner and colleagues point out that the energy ... mobility needs accounts for more than 70 percent of emissions ...
... accurately, according to a new study by the late ... in Germany. Their analysis of human melody singing in ... work is published online in Springer,s journal Animal ... one of the most complex and demanding cognitive challenges ...
... Down syndrome, more commonly known as "trisomy 21" is ... population: Alzheimer,s disease, leukemia, or cardiac deficiency. In a ... Faculty of Medicine of the University of Geneva (UNIGE), ... 21, determining the risk of congenital heart disease in ...
Cached Biology News:Songbirds turn on and tune up 2Complex genetic architectures: Some common symptoms of trisomy 21 2
(Date:9/16/2014)... 16, 2014  LABSCO, the leading specialty sales ... hospitals, physician office laboratories and alternate healthcare settings ... 2014, it will serve as Siemens Healthcare Diagnostics, ... and as a semi-exclusive sales distributor in specified ... United States . LABSCO will be ...
(Date:9/16/2014)... , Sept. 16, 2014  Ascendis Pharma ... TransCon technology to address significant unmet medical needs, ... Phase 2 pediatric study to evaluate once-weekly TransCon ... or GHD.  The full interim results will be ... GRS and IGF Society, being held October 15-18, ...
(Date:9/16/2014)... BCC Research reveals in its ... , the global market for stem cells is expected ... a five-year compound annual growth rate (CAGR) of 13.6%. ... with growth projections of $2.2 billion in 2014 to ... , Unlike other potential applications of bioscience, ...
(Date:9/16/2014)... RENU 28, the world's first and only skin gel ... in Australia and New Zealand in mid-August . , The ... tour will make stops in Brisbane on September 16, the ... on the 20th, and Melbourne on the 22nd. , Helping ... to educate people about the new product and business opportunity ...
Breaking Biology Technology:LABSCO Secures Alliance With Siemens Healthcare Diagnostics 2LABSCO Secures Alliance With Siemens Healthcare Diagnostics 3Ascendis Pharma A/S Announces Positive Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 2Ascendis Pharma A/S Announces Positive Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 3Ascendis Pharma A/S Announces Positive Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 4Global Market for Stem Cells to Reach $10.6 Billion in 2018; The Americas Growing at 13.9% CAGR 2Global Market for Stem Cells to Reach $10.6 Billion in 2018; The Americas Growing at 13.9% CAGR 3Global Wellness Company Hosts ASEA Australia Tour September 16-22 2
... EDMONTON, June 2 /PRNewswire-FirstCall/ - Quest PharmaTech ... that its 12-patient,Phase I clinical study entitled "ACP-SL017 ... Therapy of Actinic Keratosis" has met both its ... have received, for the first time, clinical,validation for ...
... 2 /PRNewswire-FirstCall/ - GeneNews Limited (TSX: GEN), a,company ... early,detection of diseases and personalized health management, today ... Company,s first,product, ColonSentry(TM)., Effective May 31, 2008, ... CEO to take on new duties as Chief ...
... genetic mutations that can affect patient response to ... ... DxS Ltd. have,signed an exclusive distribution agreement for the DxS TheraScreen ... when considered with other clinically relevant factors, to aid,doctors in identifying ...
Cached Biology Technology:Quest PharmaTech Announces Positive Results from Phase I Clinical Trial of its Photodynamic Therapy for Actinic Keratosis 2Quest PharmaTech Announces Positive Results from Phase I Clinical Trial of its Photodynamic Therapy for Actinic Keratosis 3GeneNews announces management changes to support commercialization of ColonSentry(TM) 2Roche Signs Exclusive Distribution Deal with DxS for K-RAS and EGFR Cancer Mutation Tests 2Roche Signs Exclusive Distribution Deal with DxS for K-RAS and EGFR Cancer Mutation Tests 3
Goat polyclonal to Duffy / FY / DARC...
SMVT (N-14)...
... Description: Proteinase K is a ... wide range of applications purified from the fungus ... the carboxyl group of N-substituted hydrophobic aliphatic and ... as a serine protease. Proteinase K is useful ...
... The H2OBIT™ is a fully licensed, high throughput, ... processing of up to 24 microplates. This equates ... plates. A robotic arm rapidly transfers ... resulting in temperature ramping times that are considerably ...
Biology Products: