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Sharp images from the living mouse brain
Date:2/6/2012

lig, a postdoctoral researcher in Hell's department. The genetically modified mice for these experiments originated from the group of Frank Kirchhoff at the Gttingen Max Planck Institute for Experimental Medicine. Images of the nerve cells taken seven to eight minutes apart revealed something surprising: The dendritic spine heads move and change their shape. "In the future, these super-sharp live images could even show how certain proteins are distributed at the contact points," adds Hell. With such increasingly detailed images of structures in the brain, Hell's team hopes to shed light onto the composition and function of the synapses on the molecular level.

Such insights could also help to better understand illnesses that are caused by synapse malfunction. Among these so-called synaptopathies are, for example, autism and epilepsy. As Hell explains, "Through STED microscopy and its application in living organisms, we should now be able to gain optical access of such illnesses on the molecular scale for the first time." As one of the two representatives of the Gttingen Research Center Molecular Physiology of the Brain funded by the German Research Foundation, he is committed to collaboration in his further research. Together with neurobiologists and neurologists, he and his team plan to transfer the progress made in imaging technology into fundamental knowledge about the functioning of our brains.


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Contact: Stefan W. Hell
shell@gwdg.de
49-551-201-2500
Max-Planck-Gesellschaft
Source:Eurekalert  

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