Navigation Links
Shared survival mechanism explains why 'good' nerve cells last and 'bad' cancer cells flourish
Date:12/15/2008

Specifically, according to the study, cytochrome c's ability to induce death can be turned off if the cellular environment contains high levels of antioxidants. Healthy neurons and cancer cells have increased levels of the antioxidant glutathione (GSH), which is generated by glucose metabolism through the pentose phosphate pathway. Thus, both neurons and cancer cells are able to resist cell death in part via their reliance on glucose metabolism.

"For neurons and cancer cells, evolution has come up with ways to restrict the cell death pathway. Our results provide insight into the mechanism behind this adaptive advantage," Deshmukh said. "They also bring together the fields of cancer and neurobiology and suggest that the mechanisms used by neurons to evade cell death could be the same ones adapted by dividing cells during their progression toward cancer."

The UNC scientist said his lab's further systematic explorations for other similarities between these cell types may offer insights into turning the cell death process back on in cancer cells.


'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. UI and ISU establish shared DNA sequencing instrumentation
2. Salmon smolt survival similar in Columbia and Fraser rivers
3. Research challenges conventional notions about salmon survival
4. Similar survival rates for Pacific salmon in Fraser, Columbia Rivers raises new questions
5. U of MN study shows link between gene variations and cancer survival
6. Second lumpectomy for breast cancer reduces survival rates
7. The IMF says journal editorial documents dramatic increase in survival since the 1980s
8. International team reveals first prognosticator of survival in aggressive cancer
9. The MDS Foundation supports the FDAs decision to expand vidaza label to include survival data
10. Monash researchers uncover cancer survival secrets
11. Scientists find elephant memories may hold key to survival
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Inc. (NASDAQ: NXTD and NXTDW) a biometric authentication company ... of the Wocket™ smart wallet at CES 2015 in Las ... one of the "11 Hot Products at CES" in a review published ... Far" by Newseveryday.com and "The top 10 gadgets from CES 2015" by ...
(Date:1/22/2015)... , January 22, 2015 , ... tenth year  The European Patent Office to present a ... Two British nominations to be featured: Christofer Toumazou and ... featuring former finalists and winners of the Award   ...
(Date:1/22/2015)... , Jan. 22, 2015 Infinisource has launched its ... the G2 model. The G2 sets a higher standard for ... human capital management solution. With plug-and-play installation, touch screen interface ... clock provides a robust time collection solution for the small ...
Breaking Biology News(10 mins):CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3Infinisource's NXG series sets new time clock standard 2
... called ribonucleotides become embedded in genomic DNA, which contains ... cause problems for cells. It is known that ribonucleotides ... resulting in genomic instability and altered DNA metabolism, but ... ribonucleotides. A new study provides a mechanistic explanation ...
... and colleagues have produced the most comprehensive mathematical model ... to environmental change. The research, federally ... 2 in the journal Science . ... unites various sub-disciplines of population biology, including population ecology, ...
... Los Angeles, CA (December 2nd, 2011) Most of ... new results out in the journal Clinical Rehabilitation , ... to reduce early retirement on health grounds in Finland had ... evaluative study of vocational rehabilitation, which followed 872 participants and ...
Cached Biology News:Study identifies mechanisms cells use to remove bits of RNA from DNA strands 2Powerful mathematical model greatly improves predictions for species facing climate change 2Powerful mathematical model greatly improves predictions for species facing climate change 3Costly intervention program has no measurable effect on early retirement 2Costly intervention program has no measurable effect on early retirement 3
(Date:1/22/2015)... Selexis SA, a serial innovation company with proven ... for drug discovery to commercial manufacturing, announced today all ... Sequencing (NGS) data packages. The NGS analysis of ... the integrity of the gene, validation of the left ...
(Date:1/22/2015)... , Jan. 22, 2015   GenoSpace , a precision medicine ... to enable the broad use of genomic, imaging and other ... appointment of Michelle Munson , CEO of Aspera, an ... Logo - http://photos.prnewswire.com/prnh/20150122/170713 "We ...
(Date:12/24/2014)... Dec. 24, 2014  Vermillion, Inc. (Nasdaq:   VRML), ... announced today that the Company closed its previously ... Management, Jack W. Schuler , Birchview Fund ... $10.5 million, before offering expenses.  The proceeds will ...
(Date:12/24/2014)... MA (PRWEB) December 23, 2014 ... is designed to introduce cutting edge communication technology, ... of platform upgrades. This webinar series demonstrates online ... quest to leverage web conferencing’s most innovative and ...
Breaking Biology Technology:Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2GenoSpace Expands Board with Appointment of Michelle Munson 2Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3
... is about to emerge in the world of pesticides and ... to understand the implications for public health, ensure that this ... risks, researchers say in a new report. In a ... and Environmental Health , scientists from Oregon State University and ...
... Oct. 4 Amgen (Nasdaq: AMGN ) ... ,181, pivotal Phase 3 trials evaluating Vectibix® (panitumumab) in ... and second-line treatment for metastatic colorectal cancer (mCRC), respectively, ... Oncology . "Both studies demonstrated that ...
... NEW YORK, Oct. 4 Reportlinker.com announces that ... its catalogue: Global Soft Tissue ... This report analyzes the worldwide markets ... the following segments: Cartilage Allografts, Meniscus Allografts, and ...
Cached Biology Technology:New approaches needed to gauge safety of nanotech-based pesticides 2New approaches needed to gauge safety of nanotech-based pesticides 3Two Pivotal Vectibix® Phase 3 Studies in First and Second-Line Treatment of Metastatic Colorectal Cancer Published in the Journal of Clinical Oncology 2Two Pivotal Vectibix® Phase 3 Studies in First and Second-Line Treatment of Metastatic Colorectal Cancer Published in the Journal of Clinical Oncology 3Two Pivotal Vectibix® Phase 3 Studies in First and Second-Line Treatment of Metastatic Colorectal Cancer Published in the Journal of Clinical Oncology 4Two Pivotal Vectibix® Phase 3 Studies in First and Second-Line Treatment of Metastatic Colorectal Cancer Published in the Journal of Clinical Oncology 5Two Pivotal Vectibix® Phase 3 Studies in First and Second-Line Treatment of Metastatic Colorectal Cancer Published in the Journal of Clinical Oncology 6Two Pivotal Vectibix® Phase 3 Studies in First and Second-Line Treatment of Metastatic Colorectal Cancer Published in the Journal of Clinical Oncology 7Two Pivotal Vectibix® Phase 3 Studies in First and Second-Line Treatment of Metastatic Colorectal Cancer Published in the Journal of Clinical Oncology 8Two Pivotal Vectibix® Phase 3 Studies in First and Second-Line Treatment of Metastatic Colorectal Cancer Published in the Journal of Clinical Oncology 9Two Pivotal Vectibix® Phase 3 Studies in First and Second-Line Treatment of Metastatic Colorectal Cancer Published in the Journal of Clinical Oncology 10Two Pivotal Vectibix® Phase 3 Studies in First and Second-Line Treatment of Metastatic Colorectal Cancer Published in the Journal of Clinical Oncology 11Reportlinker Adds Global Soft Tissue Allografts Industry 2Reportlinker Adds Global Soft Tissue Allografts Industry 3Reportlinker Adds Global Soft Tissue Allografts Industry 4Reportlinker Adds Global Soft Tissue Allografts Industry 5Reportlinker Adds Global Soft Tissue Allografts Industry 6Reportlinker Adds Global Soft Tissue Allografts Industry 7Reportlinker Adds Global Soft Tissue Allografts Industry 8Reportlinker Adds Global Soft Tissue Allografts Industry 9Reportlinker Adds Global Soft Tissue Allografts Industry 10Reportlinker Adds Global Soft Tissue Allografts Industry 11
This issue concentrated on the purification of proteins for specific purposes (i.e. large-scale purification, purification for therapeutic use, etc.)...
... Dunbar (1994) • This book describes ... methods for preparing samples for protein ... radiometric and bioluminescence-enhanced detection systems are ... the detection and characterization of glycoprotein ...
All serum is collected from U.S.D.A. fryers and broilers. Pricing: $15/unit for 1 - 10 units; $12/unit for 11 - 50 units...
Human HAPLN1 MAb (Clone 316119) Protein Family: Hyaluronan (HA) & HA Binding Proteins, Proteoglycan Regulators...
Biology Products: