Navigation Links
Shared survival mechanism explains why 'good' nerve cells last and 'bad' cancer cells flourish
Date:12/15/2008

CHAPEL HILL Cancer cells and nervous system neurons may not look or act alike, but both use strikingly similar ways to survive, according to new research from the University of North Carolina at Chapel Hill School of Medicine.

The study published in the December issue of Nature Cell Biology is the first to describe how neurons (nerve cells) and cancer cells achieve the common goal of inhibiting the series of biochemical events called apoptosis that eventually causes cells to break down and die.

That's good in the case of neurons, but bad when it comes to cancer.

"In neurons, inhibiting cell death is physiologically important to ensuring their long term survival," said the study's lead author, neurobiologist Mohanish Deshmukh, Ph.D., associate professor of cell and developmental biology and member of the Lineberger Comprehensive Cancer Center. "In cancer cells, blocking cell death allows them to evade the host defense systems and proliferate uncontrollably."

Both neurons and cancer cells do have something in common: relying extensively on the metabolism of glucose, a simple sugar. But until now, the advantages of this common characteristic have remained unclear.

"One reason why these results are so interesting is that neurons and cancer cells are as different from each other as you can imagine. For example, cancer cells divide continuously, whereas neurons don't divide at all," Deshmukh said.

In their research, Deshmukh and UNC graduate student Allyson Vaughn (currently a postdoctoral scientist at MIT) found that to prevent death, neurons and cancer cells use a specific metabolic pathway, or series of chemical reactions. This pathway the pentose phosphate biochemical pathway inhibits the activation of a key protein involved in the process of cell death called cytochrome c. "What we show is that both neurons and cancer cells inhibit the cell death process mediated by cytochrome c," Deshmukh said.
'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. UI and ISU establish shared DNA sequencing instrumentation
2. Salmon smolt survival similar in Columbia and Fraser rivers
3. Research challenges conventional notions about salmon survival
4. Similar survival rates for Pacific salmon in Fraser, Columbia Rivers raises new questions
5. U of MN study shows link between gene variations and cancer survival
6. Second lumpectomy for breast cancer reduces survival rates
7. The IMF says journal editorial documents dramatic increase in survival since the 1980s
8. International team reveals first prognosticator of survival in aggressive cancer
9. The MDS Foundation supports the FDAs decision to expand vidaza label to include survival data
10. Monash researchers uncover cancer survival secrets
11. Scientists find elephant memories may hold key to survival
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/11/2015)... , March 11, 2015   The ... its platform to scientifically measure and harness music ... to real-time biometrics and objective measurements of physiology, ... music at scale in large populations. It is ... technologists and clinicians perform rigorous studies and accelerate ...
(Date:3/10/2015)... OXFORD, Conn. , March 10, 2015 /PRNewswire/ ... NXTDW) ("NXT-ID" or the "Company"), a biometric authentication ... reports the company,s Wocket™ smart wallet has been ... 2015" by Rethink Modern. Rethink Modern ... sharing modern and innovative items for your home and lifestyle that ...
(Date:3/2/2015)... 2, 2015 Synaptics Inc. (NASDAQ: ... interface solutions, today announced a new implementation of ... enable rapid and secure transactions and reliable identification ... is a turnkey solution providing mouse and keyboard ... integrate fingerprint ID solutions into their product offerings, ...
Breaking Biology News(10 mins):Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 2Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 3NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 3NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 4Synaptics Unveils New Fingerprint ID Solution for Gamers 2Synaptics Unveils New Fingerprint ID Solution for Gamers 3
... carbon per year from wind erosion and dust storms affecting ... research.,Top soil is rich in nutrients and carbon but is ... Dawn, in Sydney in 2009. When wind lifts ... location of soil carbon. Some carbon falls ...
... Bowman, climate science communications expert and host of the Climate ... Peter Wadhams, two of the three authors of an article ... controversy since its release on July 24, 2013. The authors ... warming in the Arctic the release of methane from ...
... For a new study in the Journal of ... lipids affect growth performance in weaned pigs. The researchers ... According to the researchers, it is important to ... have improved over the years. Dr. Olayiwola Adeola, ...
Cached Biology News:Soil carbon 'blowing in the wind' 2Researchers re-evaluate swine nutrition 2
(Date:3/25/2015)... (PRWEB) March 25, 2015 Data ... Novel Mechanism of Action in Neuromuscular Diseases ... – Cytokinetics, Incorporated (Nasdaq: CYTK) announced the publication ... muscle troponin activator tirasemtiv in the journal Neurotherapeutics. ... IIa “Evidence of Effect” or hypothesis-generating clinical trial ...
(Date:3/25/2015)... the HAGUE, Netherlands , March 25, 2015 /PRNewswire/ ... therapy for chronic gastro-esophageal reflux disease (GERD) in the ... Surgery . 2015; 157(3):556-567 ], establishing the long ... The study included 25 patients with severe ... taking prescribed daily proton pump inhibitor (PPI) medication for ...
(Date:3/25/2015)... 25, 2015  18 piglets born recently are ... by scientists in the College of Agriculture and Natural ... breakthrough in the field of genetic engineering. Bhanu ... Animal & Avian Sciences (ANSC) and Ki-Eun Park, ... produced genome-edited pigs using a recently developed, groundbreaking ...
(Date:3/25/2015)...  CASI Pharmaceuticals, Inc. (Nasdaq: CASI ), a ... of innovative therapeutics addressing cancer and other unmet medical ... on China , announces that it ... therapy drug candidate ENMD-2076 in triple-negative breast cancer (TNBC) ... Sciences in Beijing , China.  ...
Breaking Biology Technology:Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 2Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 3Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 4Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 5Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 6EndoStim LES Stimulation therapy demonstrates long term safety and efficacy results in treating reflux patients 2EndoStim LES Stimulation therapy demonstrates long term safety and efficacy results in treating reflux patients 3University of Maryland Researchers Successfully Produce Genome-edited Pigs Using Revolutionary Technology 2CASI Pharmaceuticals Announces Initiation Of A Phase 2 Trial With ENMD-2076 In Triple-Negative Breast Cancer In China 2CASI Pharmaceuticals Announces Initiation Of A Phase 2 Trial With ENMD-2076 In Triple-Negative Breast Cancer In China 3CASI Pharmaceuticals Announces Initiation Of A Phase 2 Trial With ENMD-2076 In Triple-Negative Breast Cancer In China 4CASI Pharmaceuticals Announces Initiation Of A Phase 2 Trial With ENMD-2076 In Triple-Negative Breast Cancer In China 5
... June 24, 2011 /PRNewswire-Asia-FirstCall/ -- China Agri-Business, Inc. ... manufacturer and distributor of organic agricultural application products ... its Chinese operating subsidiary, Shaanxi Xinsheng Centennial Agriculture ... right to manage and operate Shaanxi Qinfeng Agrochemical ...
... - U.S. Department of Energy researchers have won 36 ... R&D Magazine for the most outstanding technology developments with ... annually in recognition of exceptional new products, processes, materials ... the market the previous year. "I want to ...
... 2011 BioNeutral Group Inc., (OTCBB: BONU.ob) today ... distribution phase of their revolutionary Cold Sterilant and ... BioNeutral was selected by New Jersey based T.U.C.S. ... service and distribution company, because of the superior ...
Cached Biology Technology:China Agri-Business Acquired Management and Operation Rights of Shaanxi Qinfeng Agrochemical Inc. in Xi'an, China 2China Agri-Business Acquired Management and Operation Rights of Shaanxi Qinfeng Agrochemical Inc. in Xi'an, China 3China Agri-Business Acquired Management and Operation Rights of Shaanxi Qinfeng Agrochemical Inc. in Xi'an, China 4Department of Energy projects win 36 R&D100 Awards for 2011 2Department of Energy projects win 36 R&D100 Awards for 2011 3Department of Energy projects win 36 R&D100 Awards for 2011 4Department of Energy projects win 36 R&D100 Awards for 2011 5Department of Energy projects win 36 R&D100 Awards for 2011 6Department of Energy projects win 36 R&D100 Awards for 2011 7Department of Energy projects win 36 R&D100 Awards for 2011 8Department of Energy projects win 36 R&D100 Awards for 2011 9BioNeutral Starts Commercial Deployment of Its Ygiene 206 Sterilant and Ogiene Products Within Port Authority Facilities Using T.U.C.S. Cleaning Services 2BioNeutral Starts Commercial Deployment of Its Ygiene 206 Sterilant and Ogiene Products Within Port Authority Facilities Using T.U.C.S. Cleaning Services 3BioNeutral Starts Commercial Deployment of Its Ygiene 206 Sterilant and Ogiene Products Within Port Authority Facilities Using T.U.C.S. Cleaning Services 4
...
recombination at attR1 and attR2 sites...
... Peroxidase Conjugate, 2 ml. ... enzyme molecules for use ... situ hybridization applications.High specificity ... Labeling & Detection, Protein ...
Whole rabbit blood (any breed, either sex) is collected at the time of slaughter and processed immediately at 4C, bottled, frozen and stored at -70C....
Biology Products: