Navigation Links
Shared survival mechanism explains why 'good' nerve cells last and 'bad' cancer cells flourish
Date:12/15/2008

CHAPEL HILL Cancer cells and nervous system neurons may not look or act alike, but both use strikingly similar ways to survive, according to new research from the University of North Carolina at Chapel Hill School of Medicine.

The study published in the December issue of Nature Cell Biology is the first to describe how neurons (nerve cells) and cancer cells achieve the common goal of inhibiting the series of biochemical events called apoptosis that eventually causes cells to break down and die.

That's good in the case of neurons, but bad when it comes to cancer.

"In neurons, inhibiting cell death is physiologically important to ensuring their long term survival," said the study's lead author, neurobiologist Mohanish Deshmukh, Ph.D., associate professor of cell and developmental biology and member of the Lineberger Comprehensive Cancer Center. "In cancer cells, blocking cell death allows them to evade the host defense systems and proliferate uncontrollably."

Both neurons and cancer cells do have something in common: relying extensively on the metabolism of glucose, a simple sugar. But until now, the advantages of this common characteristic have remained unclear.

"One reason why these results are so interesting is that neurons and cancer cells are as different from each other as you can imagine. For example, cancer cells divide continuously, whereas neurons don't divide at all," Deshmukh said.

In their research, Deshmukh and UNC graduate student Allyson Vaughn (currently a postdoctoral scientist at MIT) found that to prevent death, neurons and cancer cells use a specific metabolic pathway, or series of chemical reactions. This pathway the pentose phosphate biochemical pathway inhibits the activation of a key protein involved in the process of cell death called cytochrome c. "What we show is that both neurons and cancer cells inhibit the cell death process mediated by cytochrome c," Deshmukh said.
'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. UI and ISU establish shared DNA sequencing instrumentation
2. Salmon smolt survival similar in Columbia and Fraser rivers
3. Research challenges conventional notions about salmon survival
4. Similar survival rates for Pacific salmon in Fraser, Columbia Rivers raises new questions
5. U of MN study shows link between gene variations and cancer survival
6. Second lumpectomy for breast cancer reduces survival rates
7. The IMF says journal editorial documents dramatic increase in survival since the 1980s
8. International team reveals first prognosticator of survival in aggressive cancer
9. The MDS Foundation supports the FDAs decision to expand vidaza label to include survival data
10. Monash researchers uncover cancer survival secrets
11. Scientists find elephant memories may hold key to survival
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... form of camouflage: you don,t just blend in, the ... as uncommon as you might think. Kathryn Feller, from ... the larval life stages of many marine species are ... that most creatures cannot make transparent. Feller explains that ... individual eye unit with an opaque pigment to prevent ...
(Date:9/18/2014)... spend their entire lives nestling in the protective tentacles ... babies they sometimes travel hundreds of kilometres across the ... reef fish has been predicted, this is the first ... distant populations has been observed. , Dr Steve Simpson, ... the University of Exeter, and colleagues from the Australian ...
(Date:9/17/2014)... instrumental in the creation of the Santa Ana Wildfire ... fire threat potential of the powerful, hot, dry Santa ... inferno. The index was introduced Sept. 17 by the ... Diego Gas and Electric. , The index includes four ... be used to help fire agencies and other emergency ...
Breaking Biology News(10 mins):Transparent larvae hide opaque eyes behind reflections 2Expedition finds Nemo can travel great distances to connect populations 2Expedition finds Nemo can travel great distances to connect populations 3UCLA scientists play key role in developing new Santa Ana Wildfire Threat Index 2
... Science of Food and Agriculture shows that konjac gum ... of E. coli and Salmonella bacteria. The study by ... Centre, the Netherlands, shows that these foodstuffs act as binders ... to the fibrous foods instead of the gut cells of ...
... published online today in the International Journal of Obesity ... of a reduced-calorie diet, helps overweight adults lose more weight ... breakfast of equal calories. [1] This study supports previous ... of Nutrition , which showed that people who ate eggs ...
... Dalton, professor and Georgia Research Alliance Eminent Scholar of ... awarded $9.2 million as part of a major new ... Sciences, part of the National Institutes of Health. ... molecular biology, will address the molecular underpinnings of the ...
Cached Biology News:Adults who eat eggs for breakfast lose 65 percent more weight 2Adults who eat eggs for breakfast lose 65 percent more weight 3UGA researchers win $9.2 million stem cell grant from NIH 2
(Date:9/18/2014)... , Pennsylvanie, 18 septembre 2014 /PRNewswire/ ... en 1974, a été depuis ... compléter les évaluations cliniques traditionnelles par des ... Outcomes) et sur les impacts économiques des ... A cours d,une ...
(Date:9/18/2014)... September 18, 2014 OMICS Group ... globe to participate in the ‘Open Access Week’ ... to OMICS Group Pharma Journals from ... of the fastest emerging Sciences, accelerating with a ... services across the globe. The industry is gearing ...
(Date:9/18/2014)... dysplasia is a group of rare diseases that ... cartilage. Its onset hits at the fetal stage ... in the gene encoding fibroblast growth factor receptor ... of skeletal dysplasia, thanatophoric dysplasia (TD), a skeletal ... and is often lethal, and achondroplasia (ACH), which ...
(Date:9/18/2014)... weight loss and diabetes prevention, could actually hasten the ... do it in a surprising way: by changing the ... substantial population of bacteria residing in our intestines. These ... were published today in Nature . Among other ... Immunology Department, who led this research together with Prof. ...
Breaking Biology Technology:1974 - 2014 - Mapi fête ses 40 ans 2Pharma and Omics Journals to Address Global Challenges during Open Access Week 2Pharma and Omics Journals to Address Global Challenges during Open Access Week 3Researchers use iPS cells to show statin effects on diseased bone 2Researchers use iPS cells to show statin effects on diseased bone 3Gut bacteria, artificial sweeteners and glucose intolerance 2Gut bacteria, artificial sweeteners and glucose intolerance 3
... Elsevier announced today,that its flagship product Scopus, the world,s ... nearly doubling its Arts &,Humanities (A&H) titles. Access to ... April 2009. Currently the Scopus database contains 1,600,titles in ... Many countries will be better represented as ...
... Nov. 24 Imaging,Diagnostic Systems, Inc., (OTC Bulletin Board: ... pleased to announce the issuance of its,21st US Patent ... Digitization of the Temporal Point Spread,Function of the Detected ... (Logo: http://www.newscom.com/cgi-bin/prnh/20040412/IMDSLOGO ) ...
... 24 Poniard,Pharmaceuticals, Inc. (Nasdaq: PARD ... an agreement with Baxter Oncology GmbH for the,commercial ... is developing picoplatin, its lead product candidate, as ... solid tumors. The Company is,evaluating picoplatin in ...
Cached Biology Technology:Scopus to Expand Arts & Humanities Coverage 2Scopus to Expand Arts & Humanities Coverage 3Imaging Diagnostic Systems is Recognized for Its Advanced Engineering in Time-Resolved Techniques by the US Patent Office 2Imaging Diagnostic Systems is Recognized for Its Advanced Engineering in Time-Resolved Techniques by the US Patent Office 3Poniard Pharmaceuticals Announces Commercial Supply Agreement for Picoplatin 2Poniard Pharmaceuticals Announces Commercial Supply Agreement for Picoplatin 3
... were designed for full-length gene cloning and ... identify the desired cDNA clone. The first ... "Master Plate," where each well contains plasmid ... positive well(s) by gel electrophoresis of the ...
... The Rapid-Screen cDNA Library Panels were ... just three sets of PCRs to identify ... analysis is performed in a 96-well "Master ... from 5,000 clones. Having identified the positive ...
... The DSQ II (Dual-Stage Quadrupole) ... the world leader in analytical instrumentation, introduces ... the DSQ II. Based on the ... DSQ and PolarisQ GC/MS systems, the DSQ ...
... Panels were designed for full-length gene cloning ... to identify the desired cDNA clone. The ... 96-well "Master Plate," where each well contains ... the positive well(s) by gel electrophoresis of ...
Biology Products: