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Shape-sifting: NIST categorizes bio scaffolds by characteristic cell shapes
Date:2/7/2014

ey then used a mathematical technique"gyration tensors"to reduce each cell's shape to a characteristic ellipsoid. Ellipsoids can range in shape from points or spheres to flat ellipses or elongated sticks to something like an American football.

Analyzing the ellipsoid collection allowed them to categorize average cell shapes by scaffold. Cells in collagen gels and some fiber scaffolds, for example, tend toward a 1-dimensional rod shape. Other scaffolds promoted 2-dimensional disks, while a synthetic gel using a material called PEGTM* seems to encourage spheres.

"This technique," says Simon, "gives you a way to compare these different scaffolds. There are hundreds of scaffolds being advanced. It's hard to know how they differ with respect to cell morphology. By looking at the cell shape in 3D with this approach, you can compare them. You can say this one makes the cells more 3-dimensional, or this one makes the cells more like they would develop in collagen, depending on what you want. "


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Contact: Michael Baum
michael.baum@nist.gov
301-975-2763
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

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Shape-sifting: NIST categorizes bio scaffolds by characteristic cell shapes
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