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Shake hands with the invisible man
Date:9/18/2011

nge throughout our lives. But "the factors underlying the formation and pattern of fingerprints during embryonic development are largely unknown," says Prof. Sprecher. He adds that it isn't only fingertips that have patterned skin palms, toes, and the soles of the feet also feature these ridges, called dermatoglyphs.

To determine the cause of this rare condition, the researchers did a genetic analysis of the Swiss family, nine of whom have no fingerprints. They compared the genes of those with adermatoglyphia and those without to identify where the genetic alteration lies. They discovered that a skin-specific version of the gene SMARCAD1 has a regulating factor on fingerprint development. The group that presented with adermatoglyphia, Prof. Sprecher explains, were found to have decreased levels of the short skin-specific version of the gene.

An inconvenience, but little more

Now that this gene has been identified, researchers will be able to further investigate how SMARCAD1 regulates fingerprint development. While adermatoglyphia may be intriguing, and can certainly be problematic for border security, it's also non-threatening. Despite the minor issue of the hand's inability to produce sweat, says Prof. Sprecher, those affected do not otherwise suffer.

This research was carried out in collaboration with Dr. Janna Nousbeck of the Tel Aviv Sourasky Medical Center and Prof. Peter Itin of the University Hospital at Basel, Switzerland.


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Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert

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