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Sex over survival: Reproductive trait in fish impedes tissue regeneration
Date:10/19/2013

New research on the reproductive habits of zebrafish offers an explanation as to why some animals' bodies repair tissues. The research team previously noticed that male zebrafish regenerate their pectoral fins poorly, as compared to females. Their latest findings, publishing in the October 14 issue of the Cell Press journal Developmental Cell, reveal the basis for this sex-specific regenerative deficiency: structures that are used to improve reproductive success. The scenario represents an example of the tradeoffs between reproduction and survival.

Led by first author Junsu Kang, the scientists identified anatomical structures that male fish use during mating that produce a signal that impedes regeneration of the pectoral fins after injury. As such, fish appear to trade an ancient ability to regenerate tissue easily for a new-found way of enhancing reproductive success. This valuable information could help scientists begin to explain why humans are less able to regenerate tissue and could also be used to improve the body's tissue regenerative capacity.

"We discovered that male zebrafish have a very important set of structures on their pectoral fins that they use for breeding and that these structures secrete a potent molecular inhibitor of a key signaling pathway to aid their cycles of regular replacement," explains senior author Kenneth Poss of Duke University Medical Center.

Higher vertebrates like mammals generally have a diminished capacity for tissue regeneration compared with lower vertebrates like fish and salamanders. "The biology we describe here suggests a new paradigm for how tissue regenerative capacity may be lost during species evolution," says Poss. The researchers speculate that natural selection acting on traits like sexual features could have detrimental effects on tissue regenerative potential. For example, male zebrafish with more numerous or more effective breeding ornamentsand thus lower regenerative poten
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Contact: Mary Beth O'Leary
moleary@cell.com
617-397-2802
Cell Press
Source:Eurekalert  

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