Navigation Links
Sex hormones link to heart risk
Date:8/31/2008

Men are more prone to and likely to die of - heart disease compared with women of a similar age and sex hormones are to blame, according to a new University of Leicester led study

The findings of a study by Dr Maciej Tomaszewski, New Blood Lecturer in Cardiovascular Medicine in the Department of Cardiovascular Sciences at the University of Leicester, suggest that this "male disadvantage" may be related to the sex-specific effects of naturally occurring sex hormones.

The research by Dr Tomaszewski and his colleagues, which has been published on line in the journal Atherosclerosis, involved 933 men aged, on average, 19 years, from the Young Men Cardiovascular Association study. The researchers looked at ways that the sex hormones - estradiol, estrone, testosterone and androstenedione - interacted with three major risk factors of heart disease (cholesterol, blood pressure and weight).

They found that two of these sex hormones (estradiol and estrone, called together estrogens) are linked to increased levels of bad cholesterol (LDL-cholesterol) and low levels of good cholesterol (HDL-cholesterol) in men.

This suggests that certain sex hormones may be important risk factors of heart disease in men, even before they present symptoms of coronary artery disease or stroke.

Dr Tomaszewski commented: "We hypothesised that circulating concentrations of sex hormones were associated with cardiovascular disease risk factors in men long before any apparent manifestations of cardiovascular disease such as stroke or myocardial infarction".

"We examined associations of circulating estrogens (estradiol and estrone) as well as androgens (testosterone and androstenedione) with major cardiovascular risk factors (lipids, blood pressure, body mass) in 933 young (median age 19 years), apparently healthy men.

"Our studies showed that one of the sex hormones - estradiol - was associated positively with total cholesterol and negatively with HDL-cholesterol. Circulating concentrations of another sex hormone - estrone - showed strong positive associations with both total cholesterol and LDL-cholesterol.

"Thus, men with the highest concentrations of estrone and estradiol may have the highest level of cardiovascular risk as their levels of detrimental LDL-cholesterol are high whilst their cardio-protective HDL-cholesterol is low.

"Most importantly, the demonstrated associations between cholesterol and estrogens were independent of other sex hormones (testosterone and androstenedione), age, body weight, blood pressure and other potential confounding factors.

"Our data suggest that higher levels of estrogens may have negative influence on lipid profile in men early in life, before the apparent onset of cardiovascular disease.

"Why natural endogenous estrogens that are generally seen as cardio-protective in women increase cardiovascular risk in men remains to be elucidated. Future prospective studies are needed to confirm that higher levels of endogenous estrogens in youth increase the risk of heart disease later in man's life.

"A number of other investigations on sex-specific aspects of cardiovascular disease are in progress in our Department and I am sure that we will be able to continue providing information in this area of research in the future."


'/>"/>

Contact: Maciej Tomaszewski
mt142@le.ac.uk
01-162-563-028
University of Leicester
Source:Eurekalert

Related biology news :

1. Scientists uncover how hormones achieve their effects
2. New study finds anticipating a laugh reduces our stress hormones
3. Plant steroids offer new paradigm for how hormones work
4. Abnormal fat metabolism underlies heart problems in diabetic patients
5. High blood pressure, low energy -- a recipe for heart failure
6. Human derived stem cells can repair rat hearts damaged by heart attack
7. Geron Demonstrates hESC-derived cardiomyocytes improve heart function after myocardial infarction
8. Heart of Herschel to be presented to media
9. Minimally invasive heart surgery research wins NIH award
10. A step toward tissue-engineered heart structures for children
11. Research explains link between cholesterol and heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/14/2016)... SANTA CLARA, Calif. , Nov. 14, ... of the biometric identification market, Frost & ... Global Frost & Sullivan Award for Visionary ... leading player in the biometric identification market ... a multi-modal verification solution for instant, seamless, ...
(Date:6/22/2016)... 2016   Acuant , the leading ... has partnered with RightCrowd ® to ... Management, Self-Service Kiosks and Continuous Workforce Assurance. ... functional enhancements to existing physical access control ... with an automated ID verification and authentication ...
(Date:6/20/2016)... -- Securus Technologies, a leading provider of civil ... investigation, corrections and monitoring announced that after exhaustive ... the final acceptance by all three (3) Department ... (MAS) installed. Furthermore, Securus will have contracts for ... October, 2016. MAS distinguishes between legitimate wireless device ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... , ... December 01, 2016 , ... ... Science Symposium (CSS) and the popularity of US Single Day Events (SDE) to ... in early Summer 2018, in Raleigh, NC. Topics of the pharmaceutical and life ...
(Date:12/2/2016)... , ... December 01, 2016 , ... ... long-term client Nanowear on their recent FDA Class II 510(k) clearance for their ... significant hurdle in commercializing remote cardiac monitoring devices that rely on cloth-based nanosensors. ...
(Date:12/2/2016)... NEW YORK , Dec. 1, 2016   ... liquid photopurification, announced today that the Company has concluded ... has the right for a 90-day period to acquire ... invoice value of approximately USD 3.7 million.  ... an agreement with Tamarack under which Tamarack will seek ...
(Date:11/30/2016)... (PRWEB) , ... November 30, 2016 , ... ... new moving magnet Voice Coil Actuator with a flexure design that ensures high ... life with cost-effective pricing and is ideally suited where extreme precision is required, ...
Breaking Biology Technology: