Navigation Links
Sex differences in the brain's serotonin system
Date:2/13/2008

A new thesis from he Swedish medical university Karolinska Institutet shows that the brains serotonin system differs between men and women. The scientists who conducted the study think that they have found one of the reasons why depression and chronic anxiety are more common in women than in men.

Serotonin is a brain neurotransmitter that is critical to the development and treatment of depression and chronic anxiety, conditions that, for reasons still unknown, are much more common in women than in men. A research group at Karolinska Institutet has now shown using a PET scanner that women and men differ in terms of the number of binding sites for serotonin in certain parts of the brain.

Their results, which are to be presented in a doctoral thesis by Hristina Jovanovic at the end of February, show that women have a greater number of the most common serotonin receptors than men. They also show that women have lower levels of the protein that transports serotonin back into the nerve cells that secrete it. It is this protein that the most common antidepressants (SSRIs) block.

We dont know exactly what this means, but the results can help us understand why the occurrence of depression differs between the sexes and why men and women sometimes respond differently to treatment with antidepressant drugs, says associate professor Anna-Lena Nordstrm, who led the study.

The group has also shown that the serotonin system in healthy women differs from that in women with serious premenstrual mental symptoms. These results suggest that the serotonin system in such women does not respond as flexibly to the hormone swings of the menstrual cycle as that in symptom-free women.

These findings indicate that when developing antidepressants and anti-anxiety drugs, scientists should evaluate their effect on men and women separately, as well as their effects before and after menopause, says Ms Nordstrm.


'/>"/>

Contact: Katarina Sternudd
katarina.sternudd@ki.se
56-852-483-895
Karolinska Institutet
Source:Eurekalert

Page: 1

Related biology news :

1. St. Jude influenza survey uncovers key differences between bird flu and human flu
2. Claims of sex-related differences in genetic association studies often not properly validated
3. Genetic differences in clover make one type toxic
4. Analysis of breast and colon cancer genes finds many areas of differences between tumors
5. Worms take the sniff test to reveal sex differences in brain
6. Tiny genetic differences have huge consequences: McGill researchers
7. Doctors learn to control their own brains pain responses to better treat patients
8. From brains to behavior: Cold Spring Harbor Protocols features methods for neuroscience research
9. Women more depressed and men more impulsive with reduced serotonin functioning
10. Why serotonin can cause depression and anxiety
11. Bursts of waves drive immune system soldiers toward invaders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... to species, selection for traits that are attractive to ... enhances opportunities to mate, the tail of male peacocks ... of California, Riverside have now found that sexual selection ... are linked. Describing the life histories of more than ... researchers found that species with placentas tend to have ...
(Date:7/9/2014)... puzzle behind nature,s ability to split the water ... development of artificial photosynthesis for clean, green and ... collaboration of scientists led by researchers with the ... SLAC National Accelerator Laboratory. , Working at ... most powerful x-ray laser, the researchers were able ...
(Date:7/9/2014)... children with traumatic injuries have identified an immune ... develop a hospital-acquired infection. The study, led by ... in June in the journal Shock , ... lead to the clinical implementation of quick-turnaround immune ... immune system damage following critical illness or injury ...
Breaking Biology News(10 mins):Biologists link sexual selection and placenta formation 2Biologists link sexual selection and placenta formation 3Biologists link sexual selection and placenta formation 4Postcards from the photosynthetic edge 2Postcards from the photosynthetic edge 3Immune function predicts infection risk among child trauma patients 2Immune function predicts infection risk among child trauma patients 3
... released the final "Integrated Science Assessment for Oxides of ... the scientific literature on the potential adverse human health ... nitrogen dioxide or NO2. There are significant new ... review document released in 1993. Oxides of ...
... The outlook for air quality in Beijing during the Olympics ... do to improve it. That,s the conclusion drawn ... pollution data collected regularly for the last five years by ... a regional component to the pollutants that cause unhealthy air ...
... Jericho may help a joint Israeli-Palestinian-German research group combat ... the Kuvin Center for the Study of Infectious and ... is leading the Israeli team, the bones, which were ... seventy years ago, will be tested for tuberculosis, leprosy, ...
Cached Biology News:URI researcher: China can't fully fix air quality problem for Olympics 2Excavated Jericho bones may help Israeli-Palestinian-German team combat tuberculosis 2Excavated Jericho bones may help Israeli-Palestinian-German team combat tuberculosis 3
(Date:1/15/2014)... Two champions of science, technology, engineering, and mathematics ... competition for middle and high school students designed to ... The competition presents students with real-world problems experienced by ... and Sciences is a program administered by the ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider of Notched ... tinnitus. Patients listen to sound therapy that is tailor-made ... weeks to months, their tinnitus volume decreases. , AudioNotch has ... and Notched White Noise. Now, AudioNotch is pleased to announce ...
(Date:1/14/2014)... a leading provider of strategic communications services to corporations and organizations ... the United States and Europe ... is returning to the firm,s Washington, D.C. ... than two years of service as Associate Commissioner for the Office ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 iLab Solutions, the ... as the new Director of Product Strategy. In this role, ... as iLab sub-teams to guide in the development of iLab ... provides the maximum possible benefit to the scientific community by ...
Breaking Biology Technology:Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Former FDA Associate Commissioner Returns To 3D Communications 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2
... SHANGHAI, China, July 9 /Xinhua-PRNewswire/ -- WuXi PharmaTech ... research,and development outsourcing company with operations in China ... Trabue D. Bryans, Vice President,and General Manager of ... subsidiaries of WuXi PharmaTech (Cayman) Inc., has been ...
... ULURU Inc. (Amex: ULU ),today announced that ... on a recent development, Wednesday, July 9, 2008 at ... call, please dial (800) 357-0498 for,international callers dial (850) ... the initiation of the teleconference. If you are unable ...
... Biotech and pharmaceutical,firms are developing a ... the,complicated drug discovery process, reports Genetic Engineering ... on a combination,of high-throughput screening methods, miniaturization ... article in the July issue,( http://www.genengnews.com/articles/chitem.aspx?aid=2527 ) ...
Cached Biology Technology:WuXi AppTec VP and GM Invited to Join the AAMI Standards Board 2WuXi AppTec VP and GM Invited to Join the AAMI Standards Board 3ULURU Inc. Announces Update on Recent Development 2GEN Reports on Novel Hit-to-Lead Drug Discovery Strategies 2
... gasket slides/kit Gasket slide kit (1x 22K ... or Gasket slide kit ... disposable gasket slides offered in either 11K or 22K ... The gaskets are carefully fabricated and batch tested ...
... This CLS number is ... to easily match Cornings product ... yet, please order under the ... contact customer service for assistance. ...
... description: self locking design in ice/water ... new product number, created to easily ... no availability yet, please order under ... contact customer service for assistance. ID ...
... Oligo Microarray Kit (V2), 2 x ... characterize expression of many thousands of ... during important biological processes. Each microarray ... known ORFs from the S288C strain ...
Biology Products: