Navigation Links
Sex and lifespan linked in worms
Date:7/23/2008

A group of scientists who set out to study sex pheromones in a tiny worm found that the same family of pheromones also controls a stage in the worms' life cycle, the long-lived dauer larva.

The findings, published in Nature online on July 23, represent the first time that reproduction and lifespan have been linked through so-called small molecules.

Where scientists once focused on DNA and proteins as the major players in an organism's biology, they are now realizing that smaller, but more structurally diverse chemicals - simply called "small molecules" - are a significant part of a living thing's biology. "They're as important to biology as the genes are," says Frank Schroeder, last author of the paper and a scientist at the Boyce Thompson Institute.

The researchers set out to identify the sex pheromone that attracts male C. elegans worms to the more common hermaphrodites (this worm species has no females). C. elegans, a tiny nematode, is a model organism often used to study development and reproduction.

To identify the sex pheromone, the researchers tested mixtures of chemicals produced by the worms, narrowing down the possibilities until only a few remained. They discovered that a handful of sugar-like chemicals called ascarosides worked together to attract males.

"One interesting aspect is that a whole family of compounds is necessary to elicit a biological response. One by itself doesn't do much, but two or three together give a strong response," says Schroeder.

Surprisingly, the same group of compounds can also trigger young worms to enter the long-lived dauer stage.

When food is scarce or colonies become crowded, young worms stop developing normally and enter the dauer stage. In this form they can live, without eating or reproducing, for months - about ten times longer than the worm's normal lifespan. When the dauer finds greener pastures, it finally develo
'/>"/>

Contact: Frank Schroeder
fs31@cornell.edu
607-254-4391
Boyce Thompson Institute for Plant Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Drug commonly used to treat bipolar disorder dramatically increases lifespan in worms
2. Honeybee researcher to unravel properties governing lifespan with support from Norway
3. Eliminating germline lengthens fly lifespan, Brown study shows
4. Risk of common vaginal infection linked to preterm birth appears higher for blacks
5. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
6. Protein chatter linked to cancer activation
7. Western diet linked to increased risk of colon cancer recurrence
8. Sugary drinks, not fruit juice, may be linked to insulin
9. Brains timing linked with timescales of the natural visual world
10. Low vitamin D during pregnancy linked to pre-eclampsia
11. Genetic variant linked to odor perception
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... June 30, 2015 Genisphere announced ... CEO to help further develop Genisphere,s therapeutics capabilities and ... experience, having spent much of the last 25 years ... Baxter Bioscience, and Johnson & Johnson. Tom started his ... and Biotech Corporate Finance. He graduated from Dartmouth College ...
(Date:6/25/2015)... 25, 2015  Imagine a tool specifically designed to ... happier life. That,s exactly what USANA,s True Health ... cutting-edge, portable health program provides a personalized approached to ... improve your lifestyle and nutrition. At ... Wednesday night, USANA,s THA was honored with the Industry ...
(Date:6/24/2015)... 2015  Synaptics Inc. (NASDAQ: SYNA ), ... announced that Sharp has selected its industry-leading Natural ... its latest flagship smartphone device, the AQUOS ZETA ... shipments of its fingerprint ID sensor technology, this ... and leadership in the biometrics market through its ...
Breaking Biology News(10 mins):Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3@USANAinc's Personalized Nutrition Program Wins Industry Innovation Award 2Synaptics Brings Natural ID Technology to Sharp's Newest Flagship Smartphone 2
... the cell nucleus and the mitochondria. When DNA appears outside ... probably originates from a bacterial pathogen or a DNA virus. ... the innate immune system. However, various types of insult can ... cell,s own DNA. In this case, the resulting immune response ...
... Air in the United States could be ... researchers expect will help in the development of new ... Systems Integration Laboratory provides unprecedented capabilities that will be ... and other drivetrain and emissions components. The payoff is ...
... core personality dimensions that define humanity, primate researchers ... traits for humankind,s closest living relative, the chimpanzee. ... of American Journal of Primatology provides ... personality dimensions in chimpanzees: reactivity/undependability, dominance, openness, extraversion ...
Cached Biology News:Innate immunity 2June 2013 story tips 2June 2013 story tips 3June 2013 story tips 4Chimpanzees have 5 universal personality dimensions 2
(Date:7/6/2015)... ANGELES , July 6, 2015 ImmunoCellular ... establishment of an agreement with Novella Clinical ... ICT-107 in patients with newly diagnosed glioblastoma. Novella is ... trial services to small to mid-sized oncology companies. The ... sites in the US, Europe ...
(Date:7/3/2015)... 3, 2015 ... osoitteessa  http://www.openinnovationinscience.at Wienissä pidettävään ... Science" -jatkokoulutusohjelmaan 22.7.2015 asti.  ... tekemän, kansainvälisiä tutkijoita ja tiedemiehiä ... suurinta haastetta ovat kannustimien puute ...
(Date:7/3/2015)... 2015 Forskare kan ... på  http://www.openinnovationinscience.at till det återkommande utbildningsprogrammet ... hålls i Wien .  ... internationella forskare och vetenskapsmän som genomfördes av ... största utmaningar bristen på incitament för att ...
(Date:7/3/2015)... Forskere kan ansøge ... http://www.openinnovationinscience.at om efteruddannelsesprogrammet "Lab for Open ... Wien .  ... og videnskabsmænd foretaget af Ludwig Boltzmann Gesellschaft ... sundhedsvidenskaben manglen på incitamenter til at undersøge ...
Breaking Biology Technology:ImmunoCellular Therapeutics Establishes Agreement with Novella Clinical to Conduct ICT-107 Phase 3 Registration Trial in Glioblastoma 2Maailman ensimmäinen tiedemiesten koulutukseen suunniteltu avoimen innovaation ohjelma käynnistyy 2Maailman ensimmäinen tiedemiesten koulutukseen suunniteltu avoimen innovaation ohjelma käynnistyy 3Lansering av världens första program för öppen innovation för att utbilda forskare 2Lansering av världens första program för öppen innovation för att utbilda forskare 3Lancering af verdens første åbne innovationsprogram til uddannelse af forskere 2Lancering af verdens første åbne innovationsprogram til uddannelse af forskere 3
... Va., April 23 Insmed Inc. (Nasdaq CM: ... that it will host a conference call on Wednesday, ... financial results for the first quarter 2009. Insmed ... before the market opens on May 13th.To participate in ...
... April 23 /PRNewswire-Asia-FirstCall/ -- China Sky One,Medical, Inc. ("China ... CSKI ), a,leading fully integrated pharmaceutical company producing over-the-counter,drugs ... that it,obtained approvals from the State Food and Drug ... and Musk liniment for pain relief. , ...
... Idenix Pharmaceuticals, Inc. (Nasdaq: IDIX ), ... of drugs for the treatment of human viral diseases, ... programs being presented this week at the 44th Annual ... the Liver (EASL) in Copenhagen, Denmark. These presentations include ...
Cached Biology Technology:Insmed to Host First Quarter 2009 Conference Call 2China Sky One Medical, Inc. Obtains SFDA Approvals for Geranium Ointment and Musk Liniment for Pain Relief 2China Sky One Medical, Inc. Obtains SFDA Approvals for Geranium Ointment and Musk Liniment for Pain Relief 3Idenix Pharmaceuticals Reports Data From Three Hepatitis C Development Programs at the 44th Annual Meeting of the European Association for the Study of the Liver 2Idenix Pharmaceuticals Reports Data From Three Hepatitis C Development Programs at the 44th Annual Meeting of the European Association for the Study of the Liver 3Idenix Pharmaceuticals Reports Data From Three Hepatitis C Development Programs at the 44th Annual Meeting of the European Association for the Study of the Liver 4Idenix Pharmaceuticals Reports Data From Three Hepatitis C Development Programs at the 44th Annual Meeting of the European Association for the Study of the Liver 5
... PBL's bioassays for interferons are cytopathic effect ... assays. Sample types include; tissue culture supernatents; ... In these assays, one unit is defined as ... reduce the cytopathic effect of viral infection by ...
supplied with 10x reaction buffer...
... cytopathic effect inhibition assays, also known as CPE ... culture supernatents; serum from PK studies and delivery ... defined as the quantity of interferon required per ... infection by 50%. All standards used ...
... BioPrime Plus Array CGH Genomic Labeling Systems ... reproducible labeling of genomic DNA samples for ... both indirect and direct labeling formats, the ... provide a flexible solution to your genomic ...
Biology Products: