Navigation Links
Severe breathing disorders during sleep are associated with an increased risk of dying

Severe breathing disorders during sleep are associated with an increased risk of dying from any cause according to research published this week in the open access journal PLoS Medicine. The study finds that the increased risk of dying is most apparent in men between 40 and 70 years of age with severe sleep-disordered breathing, and suggests a specific link between this condition and death from coronary heart disease in men.

Sleep-disordered breathing is characterized by a collapse of the upper airway during sleep, leading to numerous, brief interruptions of breathing known as sleep apnea, and it is experienced by one in four men and one in ten women. Although it is increasingly recognised as a serious conditionlinked with hypertension, heart failure and stroke, as well as causing daytime sleepiness with dangerous consequences such as impairing a person's ability to drive safelyprevious studies investigating sleep-disordered breathing have not included participants in sufficient numbers to identify specific factors (such as age and sex) that might predict an increased risk of dying.

In the Sleep Heart Health Study, Naresh Punjabi of Johns Hopkins University, Baltimore and colleagues studied over 6,000 men and women, initially assessing their night-time breathing, sleep patterns and blood oxygen levels, and calculating each participant's apnea-hypopnea index (AHI), defined as the number of pauses in breathing severe enough to cause a 4% drop in blood oxygen saturation, per hour of sleep. Following the study participants over an average of 8 years, they found that those with severe sleep disordered breathing (AHI of 30 or above) at the outset were one and a half times more likely to die from any cause, irrespective of age, sex, race, body mass index, smoking status and prevalent medical conditions. Men aged 40-70 with severe sleep-disordered breathing were twice as likely to die from any cause as men the same age not suffering from the condition (that is, those with AHI less than 5). Death from coronary heart disease was found to be associated with sleep-disordered breathing in men, but not in women. Those who had milder sleep-breathing disorders did not have a statistically significant increased risk of dying.

As an observational study, this research cannot determine whether sleep-disordered breathing is the actual cause of deaths, rather than a factor that happens to be associated with fatal conditions, nor whether treating sleep-disorder breathing can lengthen life. To address this question, the authors suggest "additional research in the form of randomized clinical trials to assess if treatment [of sleep-disordered breathing] can reduce premature mortality associated with this common and chronic disorder."


Contact: Andrew Hyde
Public Library of Science

Related biology news :

1. Research shows rates of severe childhood obesity have tripled
2. Smaller than expected, but severe, dead zone in Gulf of Mexico
3. UF makes gene therapy advance in severe genetic disorder
4. New center at Georgia Tech aims to improve recovery of soldiers with severe injuries
5. Preclinical work shows how one gene causes severe mental retardation
6. UT Public Health researchers find link to severe Staph infections
7. Severe gestational hypertension may protect against testicular cancer
8. Franklin Square to study airway bypass procedure for severe emphysema
9. Severe climate change costs forecast for Pennsylvania, N.C., Tennessee, N.D.
10. Cortisol and fatty liver: Researchers find cause of severe metabolic disorders
11. Toxoplasmosis found more severe in Brazil compared to Europe
Post Your Comments:
(Date:11/20/2015)... 2015 NXTD ) ("NXT-ID" or ... growing mobile commerce market and creator of the Wocket® ... was recently interviewed on The RedChip Money Report ... weekend on Bloomberg Europe , Bloomberg Asia, Bloomberg ... NXTD ) ("NXT-ID" or the "Company"), a biometric ...
(Date:11/18/2015)... , Nov. 18, 2015  As new scientific discoveries ... doctors and other healthcare providers face challenges in better ... and patients. In addition, as more children continue to ... patient,s adulthood and old age. John M. ... Children,s Hospital of Philadelphia (CHOP) . --> ...
(Date:11/17/2015)... Paris , qui ... Paris , qui s,est tenu du ... leader de l,innovation biométrique, a inventé le premier scanner ... sur la même surface de balayage. Jusqu,ici, deux scanners ... les empreintes digitales. Désormais, un seul scanner est en ...
Breaking Biology News(10 mins):
(Date:11/30/2015)... DIEGO , Nov. 30, 2015  HUYA Bioscience ... China,s pharmaceutical innovations, today announced it ... Drug Development Fund (KDDF) to foster collaboration between KDDF ... development and commercialization of healthcare products for the global ... as an important source of new innovative preclinical and ...
(Date:11/30/2015)... NORTH CHICAGO, Ill. , Nov. 30, 2015 /PRNewswire/ ... an all-inclusive program that focuses on a daily routine ... how patients take their medication can affect the way ... establish and follow to their a daily routine are ... is to help patients better manage their hypothyroidism ...
(Date:11/30/2015)... , Nov. 30, 2015  Northwest Biotherapeutics (NASDAQ: ... DCVax® personalized immune therapies for solid tumor cancers, announced ... additional independent director, and the Company welcomes Neil ... in a recent anonymous internet report on NW Bio.  ... Linda Powers stated, "We agree with ...
(Date:11/30/2015)... and PETACH TIKVAH, Israel , Nov. ... BCLI ), a leading developer of adult stem cell ... Brainstorm Cell Therapeutics Ltd., has been awarded an additional grant ... of the Chief Scientist (OCS). This grant, the second this ... 2015 activities to approximately $1.8 million (approximately NIS7 million).  ...
Breaking Biology Technology: