Navigation Links
Several common differentially expressed genes between Kashin-Beck disease and Keshan disease
Date:9/14/2013

Kashin-Beck disease (KBD) and Keshan disease (KD) are major endemic diseases in China. Postgraduate Xi Wang et al., under the guidance of Professor Xiong Guo from the Institute of Endemic Diseases of the Faculty of Public Health, Medicine College of Xi'an Jiaotong University, Key Laboratory of Environment and Gene Related Diseases in Ministry of Education, Key Laboratory of Trace Elements and Endemic Diseases of Health Ministry, set out to tackle these two endemic diseases. After several years of innovative research, they have made significant progress in determining the etiology and pathogenesis of these diseases at a molecular level; in particular, the identification of some common differentially expressed genes. Their work, titled "Comparing gene expression profiles of Kashin-Beck and Keshan diseases occurring within the same endemic areas of China", was published in SCIENCE CHINA Life Sciences. 2013 Vol.56(9).

KBD and KD are distributed from the northeast to the southwest of China, where the selenium content is low in the soil. In China, there are 660000 KBD and 40000 KD patients, and approximately 30 million people are at risk. KBD is an endemic osteoarthropathy, the pathologic changes of KBD included significant alterations in chondrocyte phenotype, necrosis, and apoptosis, and abnormal terminal chondrocyte differentiation. The mainly pathologic changes of KD are multifocal myocardial necrosis and fibrosis that can result in cardiogenic shock and congestive heart failure. KD is an endemic myocardosis that happened in women and preschoolers. Since osteoarthritis and myocardium deformities, the most of KBD and KD patients will partially or completely lose their abilities to work even self-care, which seriously reduces their quality of life, and also bring heavy medical burden to society; the etiology and pathogenesis of KBD and KD remain unclear. However, both diseases happened in the same area of China. Moreover, the living conditions of KBD and
'/>"/>

Contact: GUO Xiong
guox@mail.xjtu.edu.cn
Science China Press
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Antiviral enzyme contributes to several forms of cancer, University of Minnesota researchers say
2. Birds evolved ultraviolet vision several times
3. Single protein targeted as the root biological cause of several childhood psychiatric disorders
4. NASA satellite sees several western US fires blazing
5. UCLA researchers invent portable device for common kidney tests
6. Trust in leaders, sense of belonging stir people to safeguard common goods, analysis shows
7. Common autism supplement affects endocrine system
8. Metastatic pancreatic, primary breast cancer have common growth mechanisms, study suggests
9. MacaInfo.org Offers In-Depth Answers the 20 Most Common Questions People Have about Maca
10. Toward broad-spectrum antiviral drugs for common cold and other infections
11. Complex genetic architectures: Some common symptoms of trisomy 21
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 2014 The Defense Logistics Agency is ... detect and prevent counterfeit microcircuits from entering into ... started performing an in-house microcircuit anti-counterfeit initiative dubbed ... of purchased microcircuits while increasing their reliability throughout ... will be conducted at DLA,s Electronics Product Test ...
(Date:12/17/2014)... , Dec. 16, 2014  Automation is ... this more evident than at international borders. Over ... document scanners have allowed veteran travelers to self ... Passport Control (APC) Kiosks at an increasing number ... globe. According to Maxine ...
(Date:12/11/2014)... SALEM, N.C. , Dec. 10, 2014  That blood ... for quite a while. Hypertension – the medical term for ... in the early 1800s, and the inflatable cuff that,s used ... That doesn,t, however, mean there,s nothing new about hypertension, its ... some long-held beliefs about the condition and the best ways ...
Breaking Biology News(10 mins):Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4
... The biotech industry boosted farming across the globe to ... to 2009, according to the latest analysis published in the ... the increase in net farm income, the farm level benefit ... study,s authors estimate that almost half of that was derived ...
... Md. (Sept. 19, 2011) Dietary salt intake and ... high blood pressure. Each packs its own punch, but when ... than the sum of their individual contributions. Discovering the molecular ... scientists, but research led by Toshiro Fujita, MD, professor and ...
... Bremerhaven, 19 September 2011. Earth warming will presumably not ... South Pacific Ocean. This is the conclusion drawn by ... clam shells and wood from the Antarctic. The growth ... a climate rhythm over the South Pacific during the ...
Cached Biology News:The benefits of biotech 2Abnormal activation of a protein may explain deadly link between high salt intake and obesity 250-million-year-old clam shells provide indications of future of El Nino phenomenon 2
(Date:12/17/2014)... Xeno Diagnostics has again received ... recent COLA inspection. Xeno has met all criteria ... accreditation organization. Accreditation is earned only by laboratories ... operations, demonstrate continued accuracy in the performance of ... survey. , While the Laboratory Excellence ...
(Date:12/17/2014)... 2014  Vermillion, Inc. (NASDAQ: VRML ), ... announced the next step in its expanded strategy to ... with the naming of current Chief Operating Officer, ... while current Chairman of the Board and CEO ... These changes are effective January 1, 2015. ...
(Date:12/17/2014)... , Dec. 17, 2014 Tigercat ... Phase 2 study evaluating the investigational oral NK-1 ... patients with severe, chronic itch who are unresponsive ... care, including topical steroids and antihistamines. ... in Visual Analog Scale (VAS) itch score from ...
(Date:12/15/2014)... PETACH TIKVAH, Israel , Dec. 15, ... BCLI ), a leading developer of adult stem cell ... Brainstorm Cell Therapeutics Ltd. was awarded a grant of ... Office of the Chief Scientist (OCS).  This is the ... grant support from the Office of the Chief Scientist, ...
Breaking Biology Technology:Xeno Diagnostics Receives 3rd Award for Laboratory Excellence 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 3Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 4Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4BrainStorm Receives $1,100,000 for its 8th Annual Non-Dilutive Grant from Israel's Chief Scientist Office 2BrainStorm Receives $1,100,000 for its 8th Annual Non-Dilutive Grant from Israel's Chief Scientist Office 3
... (Becton,Dickinson and Company) (NYSE: BDX ), a global medical ... investor healthcare,conferences:, Bear Stearns 10th Annual London Healthcare ... Time (4:45 a.m. U. S. Eastern Daylight Savings Time), ... 20, 2008 10:15 a.m. Eastern Daylight Savings Time ...
... KNDL ), a,leading, global full-service clinical research organization, ... PharmD, and,President and Chief Operating Officer Chris Bergen ... the company,s common stock over,a designated period. The ... long-term strategy for tax planning and asset diversification ...
... Therapeutics,Inc. (Nasdaq: HALO ), a biopharmaceutical company ... today announced,that it will release financial results for ... after market close on Thursday, March 13, 2008., ... Officer, Gregory Frost,PhD, Vice President and Chief Scientific ...
Cached Biology Technology:Kendle Leaders Adopt 10b5-1 Trading Plans 2Halozyme Therapeutics to Hold Pipeline Update Conference Call on March 14 2
... slides were designed to study protein expression patterns ... Tissue slices from three different species are ... be treated as a single histological slide for ... hybridization. This format allows a rapid analysis ...
... Gene Pulser Xcell microbial system, 100 ... used for electroporation of bacterial and ... main unit, PC module for exponential ... sterile cuvettes (5 each of 0.1 ...
... Soybean-Casein Digest Medium (TSB), USP is ... recommended for general laboratory use. Due to ... Peptone, the medium will support growth of ... serum, etc. , Product conforms to United ...
... (MSTA) slides were designed to study protein expression ... species. Tissue slices from three different species ... then be treated as a single histological slide ... hybridization. This format allows a rapid ...
Biology Products: