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Several abstracts on gout reveal true burden of disease and highlight promising new treatments
Date:5/26/2011

and allopurinol in 208 allopurinol-refractory gout patients and found in an intent-to-treat analysis that up to 79% of patients receiving the combination responded to treatment (sUA <6 mg/dL) compared to 25% on allopurinol, the current standard of care, plus placebo.

After four weeks, patients receiving the combination treatment showed up to a 30% reduction in sUA from baseline (allopurinol alone) compared to a 3% increase in sUA for the patients in the allopurinol plus placebo group, and adverse events (AEs) were comparable between groups.

Abstract Number: OP0111

Drinking four or more sugar sweetened beverages increases gout risk four-fold

A study from New Zealand examined the association between gout and sugar-sweetened beverages (including soft-drinks and fruit juices), primarily sweetened with sucrose, in 1,386 people from various ethnic groups.

The results of the study showed that, similar to an association found in US study participants, consuming four or more sugar-sweetened beverages (defined as one can or large glass) was associated with an up to four-fold increase in developing gout across ethnicities. Authors suggest that the association could be due to the effect of fructose on sUA concentrations, through the production of adenosine monophosphate (a nucleotide in RNA) which is converted into uric acid.

Abstract Number: THU0003


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Contact: Rory Berrie
rory.berrie@cohnwolfe.com
44-790-151-3297
European League Against Rheumatism
Source:Eurekalert

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