Navigation Links
Several abstracts on gout reveal true burden of disease and highlight promising new treatments
Date:5/26/2011

A pan-European study of 755 gout patients found that prevalence of self-reported gout was highest in the UK (2.2%) and lowest in France (0.76%). French, German and British gout patients all had lower quality of life scores, and had significant work and social impairment compared to controls (p<0.05 for all comparisons). Interestingly, patients in these countries also had more hypertension, diabetes, congestive heart failure and renal disease (p=0.05) compared to healthy controls.

Abstract Number: FRI0275-HP

Phase III study demonstrates long term efficacy and safety of pegloticase (Krystexxa)

Results of an American study show that 42% of patients treated with pegloticase (8mg every 2 weeks) achieved normal sUA after six months of treatment and of those patients who elected to continue in an open label extension 84% were able to be safely and effectively treated long term (> 2 years). Conclusions from an analysis of these responder patients suggests that subjects who have normalised their sUA after six months on pegloticase (8 mg every 2 weeks) may be able to experience a gap in therapy for as long as 167 days without losing subsequent responsiveness to treatment.

The analysis of data from a 26-week randomised controlled trial (RCT), followed by a 30-month open-label extension (OLE) showed that 90% of these responder patients had complete resolution of tophi at 50 weeks. There were clinically relevant significant reductions in the number of gout flares, tender and swollen joints and improvements in patient-reported outcomes, including pain, physical function and quality of life. There were no remarkable safety concerns with these persistent responders.

Abstract Number: OP0113

Lesinurad and allopurinol combination more effective than allopurinol alone

Researchers from Western and Eastern Europe, Canada, Spain and the USA studied the efficacy and safety of combination treatment with lesinurad and allopurinol in 208 allopurinol-refractory gout patients and found in an intent-to-treat analysis that up to 79% of patients receiving the combination responded to treatment (sUA <6 mg/dL) compared to 25% on allopurinol, the current standard of care, plus placebo.

After four weeks, patients receiving the combination treatment showed up to a 30% reduction in sUA from baseline (allopurinol alone) compared to a 3% increase in sUA for the patients in the allopurinol plus placebo group, and adverse events (AEs) were comparable between groups.

Abstract Number: OP0111

Drinking four or more sugar sweetened beverages increases gout risk four-fold

A study from New Zealand examined the association between gout and sugar-sweetened beverages (including soft-drinks and fruit juices), primarily sweetened with sucrose, in 1,386 people from various ethnic groups.

The results of the study showed that, similar to an association found in US study participants, consuming four or more sugar-sweetened beverages (defined as one can or large glass) was associated with an up to four-fold increase in developing gout across ethnicities. Authors suggest that the association could be due to the effect of fructose on sUA concentrations, through the production of adenosine monophosphate (a nucleotide in RNA) which is converted into uric acid.

Abstract Number: THU0003


'/>"/>

Contact: Rory Berrie
rory.berrie@cohnwolfe.com
44-790-151-3297
European League Against Rheumatism
Source:Eurekalert

Related biology news :

1. Several baffling puzzles in protein molecular structure solved with new method
2. Aware to Introduce Several New Software Products at the Biometrics Consortium Conference
3. Insulin may reduce several inflammatory factors induced by bacterial infection
4. Owners should count calories for obese pets, consider several factors for good health
5. Holding breath for several minutes elevates marker for brain damage
6. Scientists uncover mode of action of enzyme linked with several types of cancer
7. CCNY, CSHL biologists find birdsong of isolates reverts to norm over several generations
8. Research synthesis shines light on several management options after fires in diverse ecosystems
9. Vitamin D a key player in overall health of several body organs, says UC Riverside biochemist
10. Abstracts for the EORTC-NCI-AACR Symposium in Berlin go up online on Friday, Oct. 29
11. Call for abstracts and registration the EMBO Meeting 2010
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2016)... May 20, 2016  VoiceIt is excited to ... VoicePass. By working together, VoiceIt and ... VoiceIt and VoicePass take slightly different approaches to ... both security and usability. ... this new partnership. "This marketing and ...
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 ... of Infosys (NYSE: INFY ), and Samsung SDS, ... partnership that will provide end customers with a more ... payment services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ) ... financial services, but it also plays a fundamental part in ...
(Date:4/15/2016)... , April 15, 2016  A new partnership ... more accurate underwriting decisions in a fraction of ... competitively priced and high-value life insurance policies to ... With Force Diagnostics, rapid testing (A1C, ... data readings (blood pressure, weight, pulse, BMI, and ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 27, 2016  Alex,s Lemonade Stand Foundation (ALSF), a ... will open a state-of-the-art bioinformatics lab, using ,big data, ... announcement comes as Liz Scott , co-executive director ... Moonshot Summit in Washington, D.C. , ... participant and advocate of pediatric cancer research and awareness. ...
(Date:6/27/2016)... June 27, 2016  Global demand for enzymes ... through 2020 to $7.2 billion.  This market includes ... cleaning products, biofuel production, animal feed, and other ... and biocatalysts). Food and beverages will remain the ... increasing consumption of products containing enzymes in developing ...
(Date:6/27/2016)... , June 27, 2016 /PRNewswire/ - BIOREM Inc. (TSX-V: ... been advised by its major shareholders, Clean Technology Fund ... United States based venture capital funds ... of Biorem (on a fully diluted, as converted basis), ... disposition of their entire equity holdings in Biorem to ...
(Date:6/27/2016)...  Sequenom, Inc. (NASDAQ: SQNM ), a ... the development of innovative products and services, announced today ... States denied its petition to review decisions ... U.S. Patent No. 6,258,540 (",540 Patent") are not patent ... Supreme Court,s Mayo Collaborative Services v. Prometheus Laboratories decision.  ...
Breaking Biology Technology: