Navigation Links
Several abstracts on gout reveal true burden of disease and highlight promising new treatments

A pan-European study of 755 gout patients found that prevalence of self-reported gout was highest in the UK (2.2%) and lowest in France (0.76%). French, German and British gout patients all had lower quality of life scores, and had significant work and social impairment compared to controls (p<0.05 for all comparisons). Interestingly, patients in these countries also had more hypertension, diabetes, congestive heart failure and renal disease (p=0.05) compared to healthy controls.

Abstract Number: FRI0275-HP

Phase III study demonstrates long term efficacy and safety of pegloticase (Krystexxa)

Results of an American study show that 42% of patients treated with pegloticase (8mg every 2 weeks) achieved normal sUA after six months of treatment and of those patients who elected to continue in an open label extension 84% were able to be safely and effectively treated long term (> 2 years). Conclusions from an analysis of these responder patients suggests that subjects who have normalised their sUA after six months on pegloticase (8 mg every 2 weeks) may be able to experience a gap in therapy for as long as 167 days without losing subsequent responsiveness to treatment.

The analysis of data from a 26-week randomised controlled trial (RCT), followed by a 30-month open-label extension (OLE) showed that 90% of these responder patients had complete resolution of tophi at 50 weeks. There were clinically relevant significant reductions in the number of gout flares, tender and swollen joints and improvements in patient-reported outcomes, including pain, physical function and quality of life. There were no remarkable safety concerns with these persistent responders.

Abstract Number: OP0113

Lesinurad and allopurinol combination more effective than allopurinol alone

Researchers from Western and Eastern Europe, Canada, Spain and the USA studied the efficacy and safety of combination treatment with lesinurad and allopurinol in 208 allopurinol-refractory gout patients and found in an intent-to-treat analysis that up to 79% of patients receiving the combination responded to treatment (sUA <6 mg/dL) compared to 25% on allopurinol, the current standard of care, plus placebo.

After four weeks, patients receiving the combination treatment showed up to a 30% reduction in sUA from baseline (allopurinol alone) compared to a 3% increase in sUA for the patients in the allopurinol plus placebo group, and adverse events (AEs) were comparable between groups.

Abstract Number: OP0111

Drinking four or more sugar sweetened beverages increases gout risk four-fold

A study from New Zealand examined the association between gout and sugar-sweetened beverages (including soft-drinks and fruit juices), primarily sweetened with sucrose, in 1,386 people from various ethnic groups.

The results of the study showed that, similar to an association found in US study participants, consuming four or more sugar-sweetened beverages (defined as one can or large glass) was associated with an up to four-fold increase in developing gout across ethnicities. Authors suggest that the association could be due to the effect of fructose on sUA concentrations, through the production of adenosine monophosphate (a nucleotide in RNA) which is converted into uric acid.

Abstract Number: THU0003


Contact: Rory Berrie
European League Against Rheumatism

Related biology news :

1. Several baffling puzzles in protein molecular structure solved with new method
2. Aware to Introduce Several New Software Products at the Biometrics Consortium Conference
3. Insulin may reduce several inflammatory factors induced by bacterial infection
4. Owners should count calories for obese pets, consider several factors for good health
5. Holding breath for several minutes elevates marker for brain damage
6. Scientists uncover mode of action of enzyme linked with several types of cancer
7. CCNY, CSHL biologists find birdsong of isolates reverts to norm over several generations
8. Research synthesis shines light on several management options after fires in diverse ecosystems
9. Vitamin D a key player in overall health of several body organs, says UC Riverside biochemist
10. Abstracts for the EORTC-NCI-AACR Symposium in Berlin go up online on Friday, Oct. 29
11. Call for abstracts and registration the EMBO Meeting 2010
Post Your Comments:
(Date:5/16/2017)... May 16, 2017  Veratad Technologies, LLC ( ... age and identity verification solutions, announced today they will ... 2017, May 15 thru May 17, 2017, in ... International Trade Center. Identity impacts the ... in today,s quickly evolving digital world, defining identity is ...
(Date:5/6/2017)... -- RAM Group , Singaporean based technology ... biometric authentication based on a novel  quantum-state ... perform biometric authentication. These new sensors are based on a ... Group and its partners. This sensor will have widespread ... security. Ram Group is a next generation sensor ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... the pharmaceutical and biotechnology industries to improve patient outcomes and quality of life, ... in analytical testing are being attributed to new regulatory requirements for all new ...
(Date:10/11/2017)... ... October 11, 2017 , ... At its national board ... Suneel I. Sheikh, the co-founder, CEO and chief research scientist of Minnesota-based Advanced ... for membership in ARCS Alumni Hall of Fame . ASTER Labs is ...
(Date:10/11/2017)... ... ... wash is a basic first aid supply for any work environment, but most personal eye ... first if a dangerous substance enters both eyes? It’s one less decision, and likely quicker ... eye piece. , “Whether its dirt and debris, or an acid or alkali, getting anything ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... today it will be hosting a Webinar titled, “Pathology is going digital. Is ... , on digital pathology adoption best practices and how Proscia improves lab economics ...
Breaking Biology Technology: