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Several abstracts on gout reveal true burden of disease and highlight promising new treatments
Date:5/26/2011

A pan-European study of 755 gout patients found that prevalence of self-reported gout was highest in the UK (2.2%) and lowest in France (0.76%). French, German and British gout patients all had lower quality of life scores, and had significant work and social impairment compared to controls (p<0.05 for all comparisons). Interestingly, patients in these countries also had more hypertension, diabetes, congestive heart failure and renal disease (p=0.05) compared to healthy controls.

Abstract Number: FRI0275-HP

Phase III study demonstrates long term efficacy and safety of pegloticase (Krystexxa)

Results of an American study show that 42% of patients treated with pegloticase (8mg every 2 weeks) achieved normal sUA after six months of treatment and of those patients who elected to continue in an open label extension 84% were able to be safely and effectively treated long term (> 2 years). Conclusions from an analysis of these responder patients suggests that subjects who have normalised their sUA after six months on pegloticase (8 mg every 2 weeks) may be able to experience a gap in therapy for as long as 167 days without losing subsequent responsiveness to treatment.

The analysis of data from a 26-week randomised controlled trial (RCT), followed by a 30-month open-label extension (OLE) showed that 90% of these responder patients had complete resolution of tophi at 50 weeks. There were clinically relevant significant reductions in the number of gout flares, tender and swollen joints and improvements in patient-reported outcomes, including pain, physical function and quality of life. There were no remarkable safety concerns with these persistent responders.

Abstract Number: OP0113

Lesinurad and allopurinol combination more effective than allopurinol alone

Researchers from Western and Eastern Europe, Canada, Spain and the USA studied the efficacy and safety of combination treatment with lesinurad
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Contact: Rory Berrie
rory.berrie@cohnwolfe.com
44-790-151-3297
European League Against Rheumatism
Source:Eurekalert

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