Navigation Links
Serotonin mediates exercise-induced generation of new neurons
Date:5/13/2013

Scientists have known for some time that exercise induces neurogenesis in a specific brain region, the hippocampus. However, until this study, the underlying mechanism was not fully understood. The hippocampus plays an important role in learning and in memory and is one of the brain regions where new neurons are generated throughout life.

Serotonin facilitates precursor cell maturation

The researchers demonstrated that mice with the ability to produce serotonin are likely to release more of this hormone during exercise, which in turn increases cell proliferation of precursor cells in the hippocampus. Furthermore, serotonin seems to facilitate the transition of stem to progenitor cells that become neurons in the adult mouse brain.

For Dr. Klempin and Dr. Alenina it was surprising that normal baseline neurogenesis occurs in mice that, due to a genetic mutation, cannot produce serotonin in the brain. However, they noted that some of the stem cells in serotonin-deficient mice either die or fail to become neurons.

Yet, these animals seem to have a mechanism that allows compensation for the deficit, in that progenitor cells, an intermediate stage in the development from a stem cell to a neuron, divide more frequently. According to the researchers, this is to maintain the pool of these cells.

However, the group of wheel-running mice that do not produce serotonin did not exhibit an exercise-induced increase in neurogenesis. The compensatory mechanism failed following running. The researchers concluded: "Serotonin is not necessarily required for baseline generation of new neurons in the adult brain, but is essential for exercise-induced hippocampal neurogenesis."

Hope for new approaches to treat depression and memory loss in the elderly

Deficiency in serotonin, popularly known as the "molecule of happiness", has been considered in the context of theories linking major depression to declining neurogenesis in the adult brain. "Our findings could potentially help to develop new approaches to prevent and treat depression as well as age-related decline in learning and memory," said Dr. Klempin and Dr. Alenina.


'/>"/>

Contact: Bachtler, Barbara
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Related biology news :

1. Probing the roots of depression by tracking serotonin regulation at a new level
2. G protein-coupled receptor mediates the action of castor oil
3. Researchers discover a missing link in signals contributing to neurodegeneration
4. Researchers find novel way plants pass traits to next generation
5. U of M researchers utilize genetically corrected stem cells to spark muscle regeneration
6. Bone marrow cells used in bladder regeneration
7. Life experiences put their stamp on the next generation: New insights from epigenetics
8. Growth factor aids stem cell regeneration after radiation damage
9. UT Dallas researchers awarded $4.3 million to create next-generation technologies
10. 3-D biomimetic scaffolds support regeneration of complex tissues from stem cells
11. Described a key mechanism in muscle regeneration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/15/2016)... ALBANY, New York , March 15, 2016 ... a new market report published by Transparency Market Research "Digital ... Growth, Trends and Forecast 2015 - 2023," the global digital ... at US$ 731.9 Mn in 2014 and is forecast to ... to 2023. Growth of micro, small and medium enterprises (MSMEs) ...
(Date:3/11/2016)... 11, 2016 --> ... report "Image Recognition Market by Technology (Pattern Recognition), by ... by Deployment Type (On-Premises and Cloud), by Industry Vertical ... by MarketsandMarkets, the global market is expected to grow ... Billion by 2020, at a CAGR of 19.1%. ...
(Date:3/9/2016)... BEACH GARDENS, Fla. , March 9, 2016 ... identity management authentication and enrollment solutions, today announced ... DigitalPersona ® Altus multi-factor authentication ... IT and InfoSec managers to step-up security where ... Washington, DC . ...
Breaking Biology News(10 mins):
(Date:4/26/2016)... (PRWEB) , ... April 26, 2016 , ... The ... has been selected as one of three finalists for the European Inventor Award 2016 ... annual innovation prize will be announced at a ceremony in Lisbon on June 9th. ...
(Date:4/26/2016)... ... ... Mr. Palmer created the RPO business for Ceridian and lead the Public ... contract in the U.S. intelligence community with The SI (a Lockheed Martin divestiture). , ... of Accolo. “We are growing and his experience guiding our expansion is unparalleled. ...
(Date:4/26/2016)... (PRWEB) , ... April 26, 2016 , ... BioFactura, ... $1.8M Series A round of financing. Healthy investor interest drove significant oversubscription of ... of generic biologics, known as biosimilars, to the advanced preclinical stages. , Chief Executive ...
(Date:4/26/2016)... BUDAPEST, Hungary , VIENNA ... 26, 2016 The prize ... and the resulting revolutionary innovations that will benefit ... (Logo: http://photos.prnewswire.com/prnh/20160210/331945LOGO ) , ... developing novel proprietary trend setting products in the ...
Breaking Biology Technology: