Navigation Links
Serotonin mediates exercise-induced generation of new neurons
Date:5/13/2013

Scientists have known for some time that exercise induces neurogenesis in a specific brain region, the hippocampus. However, until this study, the underlying mechanism was not fully understood. The hippocampus plays an important role in learning and in memory and is one of the brain regions where new neurons are generated throughout life.

Serotonin facilitates precursor cell maturation

The researchers demonstrated that mice with the ability to produce serotonin are likely to release more of this hormone during exercise, which in turn increases cell proliferation of precursor cells in the hippocampus. Furthermore, serotonin seems to facilitate the transition of stem to progenitor cells that become neurons in the adult mouse brain.

For Dr. Klempin and Dr. Alenina it was surprising that normal baseline neurogenesis occurs in mice that, due to a genetic mutation, cannot produce serotonin in the brain. However, they noted that some of the stem cells in serotonin-deficient mice either die or fail to become neurons.

Yet, these animals seem to have a mechanism that allows compensation for the deficit, in that progenitor cells, an intermediate stage in the development from a stem cell to a neuron, divide more frequently. According to the researchers, this is to maintain the pool of these cells.

However, the group of wheel-running mice that do not produce serotonin did not exhibit an exercise-induced increase in neurogenesis. The compensatory mechanism failed following running. The researchers concluded: "Serotonin is not necessarily required for baseline generation of new neurons in the adult brain, but is essential for exercise-induced hippocampal neurogenesis."

Hope for new approaches to treat depression and memory loss in the elderly

Deficiency in serotonin, popularly known as the "molecule of happiness", has been considered in the context of theories linking major depression to declining neurogene
'/>"/>

Contact: Bachtler, Barbara
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. Probing the roots of depression by tracking serotonin regulation at a new level
2. G protein-coupled receptor mediates the action of castor oil
3. Researchers discover a missing link in signals contributing to neurodegeneration
4. Researchers find novel way plants pass traits to next generation
5. U of M researchers utilize genetically corrected stem cells to spark muscle regeneration
6. Bone marrow cells used in bladder regeneration
7. Life experiences put their stamp on the next generation: New insights from epigenetics
8. Growth factor aids stem cell regeneration after radiation damage
9. UT Dallas researchers awarded $4.3 million to create next-generation technologies
10. 3-D biomimetic scaffolds support regeneration of complex tissues from stem cells
11. Described a key mechanism in muscle regeneration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... have captured the popular attention of both children and ... -- sold as dehydrated eggs, these tiny brine shrimp ... a tank of salt water. , Physicists, though, ... brine shrimp vertically migrate in large groups in response ... at night and retreating deeper during the day. , ...
(Date:9/30/2014)... water may increase the risk of stillbirth and ... by a Boston University School of Public Health ... Environmental Health , compared 1,091 PCE-exposed pregnancies ... Cape Cod, Ma., where water was contaminated in ... the installation of vinyl-lined asbestos cement pipes. PCE ...
(Date:9/30/2014)... farm runoff in Hawaii is causing tumors in endangered ... study, published Tuesday in the peer-reviewed open-access journal ... up in algae that the turtles eat, promoting the ... internal organs. , Scientists at Duke University, the University ... (NOAA) conducted the study to better understand the causes ...
Breaking Biology News(10 mins):Laser-guided sea monkeys show how zooplankton migrations may affect global ocean currents 2Contaminated water linked to pregnancy complications, BU study finds 2Pollution linked to lethal sea turtle tumors 2Pollution linked to lethal sea turtle tumors 3
... 2012 Chiltern International Limited (Chiltern), a global contract ... James Gunter have joined Chiltern, bringing their expertise in ... strengthen our Global Clinical Development services. ... Cedric Burg has been appointed to the position of ...
... pests by using ultrasonic frequencies are available and marketed ... been demonstrated as being effective in repelling insect pests ... of evidence for the efficacy of such devices, they ... bugs are readily available. However, according to a ...
... reprogramming a 7-year-old girl,s own immune cells to attack ... has achieved a complete response in his patient, who ... The innovative experimental therapy used bioengineered T cells, custom-designed ... leukemia cells. After the treatment, the child,s doctors found ...
Cached Biology News:Chiltern Welcomes Cedric Burg And James Gunter 2Engineered immune cells produce complete response in child with an aggressive pediatric leukemia 2Engineered immune cells produce complete response in child with an aggressive pediatric leukemia 3
(Date:10/1/2014)... The U.S. Department of Labor has awarded ... as part of the Trade Adjustment Assistance Community College ... by the Department of Labor and Department of Education. ... E. Perez and Secretary of Education Arne Duncan announced ... to nearly 270 colleges across the country. , ...
(Date:9/30/2014)... . , The researchers ... semiconductor layer. Quantum dots are small structures that spontaneously emit ... laser pulse is fired at the photonic crystal, its refractive ... in the electromagnetic field around it. This change can speed ... dot. As soon as the refractive index recovers its usual ...
(Date:9/30/2014)... Mass. Using a bio-mimicking analog of one ... grass, an international research team led by Alejandro ... taken a major step in developing long-sought polymer ... electricity for use in electronic devices. , ... Amherst and others at Stanford University and Dresden ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 Shimadzu ... extensometer, an easy-to-use and highly precise tool for ... with considerable elongation. With 1000-mm maximum movement distance, ... percent for a gauge length of 10 mm. ... measurement accuracy above 50-mm stroke and within +/- ...
Breaking Biology Technology:U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 3U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 4Ultrafast remote switching of light emission 2Blades of grass inspire advance in organic solar cells 2Blades of grass inspire advance in organic solar cells 3Shimadzu’s New Long-Travel Extensometer Increases Precision for Soft Material Testing 2
... Products offer biologically safer water through point-of-use ... ... NEP ),a medical device company, announced today that it will ... Healthcare,Engineering (ASHE) Conference and Technical Exhibition in National Harbor,Maryland, July 20th-23rd, ...
... RICHMOND, Va., July 14, 2008 Insmed Inc.,(Nasdaq ... for unmet medical needs, today announced that the,Company ... (RBC) to act as,its strategic financial advisor., ... are dedicated,to enhancing shareholder value and will be ...
... PARK, Calif., July 14 Pacific Biosciences,announced today ... Series E private,equity financing round. The proceeds will ... company,s innovative single-molecule, real-time,(SMRT(TM)) DNA sequencing platform., ... and Intel,Capital, Intel Corporation,s global investment organization. Other ...
Cached Biology Technology:Nephros Exhibiting at Maryland Ashe Conference July 20th-23rd 2Nephros Exhibiting at Maryland Ashe Conference July 20th-23rd 3Nephros Exhibiting at Maryland Ashe Conference July 20th-23rd 4Insmed Retains RBC Capital Markets as Strategic Financial Advisor 2Insmed Retains RBC Capital Markets as Strategic Financial Advisor 3Pacific Biosciences Raises $100 Million to Fund Commercial Product Development 2
... cDNA Library Panels were designed for full-length ... of PCRs to identify the desired cDNA ... in a 96-well "Master Plate," where each ... Having identified the positive well(s) by gel ...
... cDNA Library Panels were designed for full-length ... of PCRs to identify the desired cDNA ... in a 96-well "Master Plate," where each ... Having identified the positive well(s) by gel ...
... 435 is an affordable, compact benchtop ... slides, providing a broad array of ... acquires high-resolution images with high-performance laser ... excitation and emission filter changers, and ...
... Contents include: Microarray hybridization chamber ... chamber top, clamp, thumbscrew) Microarray chamber user ... and are intended to be cleaned and ... with Agilents Catalog Oligo Microarray kits and ...
Biology Products: