Navigation Links
Septic shock: Nitric oxide beneficial after all

Ghent, 15 December 2009 - Scientists at VIB and Ghent University in Flanders, Belgium have found an unexpected ally for the treatment of septic shock, the major cause of death in intensive care units. By inducing the release of nitric oxide (NO) gas in mice with septic shock, researchers Anje Cauwels and Peter Brouckaert discovered that the animal's organs showed much less damage, while their chances of survival increased significantly. That's contrary to all expectations, since it is generally assumed that nitric oxide is responsible for the potentially lethal drop in blood pressure in septic shock.

Septic shock, or sepsis, is a medical condition in which acute inflammation, low blood pressure, and blood clotting cause a dangerous decrease in the delivery of blood to the organs. Because of the lack of oxygen, the patient's organs start to fail, one after the other. Currently, only supportive treatment is available.

It is generally assumed that nitric oxide (NO) gas is responsible for the hypotension and cardiovascular collapse in septic shock. Therefore, a lot of medical research is focused on combating NO, which is also a messenger molecule in the body. Attempts to inhibit its production paradoxically led to a worsening of the organ damage and in an increased lethality, both in animal models and in a clinical trial in sepsis patients. This led to the assumption that NO also has positive effects in sepsis, but up to now NO remained a prime suspect for the pathogenesis of the cardiovascular shock.

The team in Ghent is turning this paradigm upside-down in an article that will appear in The Journal of Experimental Medicine on Monday 21 December 2009. During their research, Cauwels and Brouckaert administered nitrite − a substance that releases NO − to mice with septic shock. The nitrite treatment, in sharp contrast with the worsening effect of inhibiting NO-synthesis, significantly attenuates hypothermia, mitochondrial damage, oxidative stress and dysfunction, tissue infarction, and mortality in mice. It is not yet known what mechanisms are at work behind this observation. That will be the subject of further research.

For now, not only is this discovery revolutionizing the way in which scientists view nitric oxide's role in septic shock − it also opens possibilities for treatment. Instead of trying to prevent the effects of NO, they should rather be imitated or reinforced to provide a solution for saving organs or particular parts of the body where there is a lack of oxygen due to septic shock.


Contact: Joris Gansemans
VIB (the Flanders Institute for Biotechnology)

Related biology news :

1. Immune system protein accurate predictor of survival in pediatric septic shock
2. CEL-SCI Corporation to Launch Aseptic Filling for Stem Cell Produced Therapies and Other Biological Products
3. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
4. Elevated nitric oxide in blood is key to high altitude function for Tibetans
5. Nitric oxide regulates plants as well as people
6. Mice use specialized neurons to detect carbon dioxide in the air
7. New membrane strips carbon dioxide from natural gas faster and better
8. US fires release large amounts of carbon dioxide
9. Nitrous oxide from ocean microbes
10. Food source threatened by carbon dioxide
11. New model revises estimates of terrestrial carbon dioxide uptake
Post Your Comments:
(Date:10/27/2015)... -- Munich, Germany , October ... automatically maps data from mobile eye tracking videos created ... that they can be quantitatively analyzed with SMI,s analysis ... , October 28-29, 2015. SMI,s Automated Semantic Gaze ... tracking videos created with SMI,s Eye Tracking Glasses ...
(Date:10/26/2015)... India , October 26, 2015 ... --> adds ... 2015 to 2021 as well as ... 2015-2019 research reports to its collection ... . --> ...
(Date:10/26/2015)... 26, 2015  Delta ID Inc., a company focused ... and PC devices, announced its ActiveIRIS® technology powers the ... F-02H launched by NTT DOCOMO, INC in ... second smartphone to include iris recognition technology, after a ... F-04G in May 2015, world,s first smartphone to have ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... Muncie, IN (PRWEB) , ... November 24, 2015 , ... ... its newest Special Interest Group (SIG), MultiGP, also known as Multirotor Grand Prix, to ... in the last few years. Many AMA members have embraced this type of racing ...
(Date:11/24/2015)... , Nov. 24, 2015  Tikcro Technologies Ltd. (OTCQB: TIKRF) today announced ... 29, 2015 at 11:00 a.m. Israel time, at ... 98 Yigal Allon Street, 36 th Floor, Tel Aviv, ... Eric Paneth and Izhak Tamir to the Board of ... as external directors; , approval of an amendment to certain terms ...
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... ... and the environment are paramount. Insertion points for in-line sensors can represent a ... developed the InTrac 781/784 series of retractable sensor housings , which are ...
(Date:11/24/2015)... LAVAL, QC , Nov. 24, 2015 /CNW Telbec/ - ... the "Corporation") announced today that Mr. Pierre Laurin , ... a corporate presentation at the upcoming Piper Jaffray 27 th ... York Palace Hotel, on December 1-2, 2015. ... be available for one-on-one meetings throughout the day. The presentation ...
Breaking Biology Technology: