Navigation Links
Septic shock: Nitric oxide beneficial after all
Date:12/15/2009

Ghent, 15 December 2009 - Scientists at VIB and Ghent University in Flanders, Belgium have found an unexpected ally for the treatment of septic shock, the major cause of death in intensive care units. By inducing the release of nitric oxide (NO) gas in mice with septic shock, researchers Anje Cauwels and Peter Brouckaert discovered that the animal's organs showed much less damage, while their chances of survival increased significantly. That's contrary to all expectations, since it is generally assumed that nitric oxide is responsible for the potentially lethal drop in blood pressure in septic shock.

Septic shock, or sepsis, is a medical condition in which acute inflammation, low blood pressure, and blood clotting cause a dangerous decrease in the delivery of blood to the organs. Because of the lack of oxygen, the patient's organs start to fail, one after the other. Currently, only supportive treatment is available.

It is generally assumed that nitric oxide (NO) gas is responsible for the hypotension and cardiovascular collapse in septic shock. Therefore, a lot of medical research is focused on combating NO, which is also a messenger molecule in the body. Attempts to inhibit its production paradoxically led to a worsening of the organ damage and in an increased lethality, both in animal models and in a clinical trial in sepsis patients. This led to the assumption that NO also has positive effects in sepsis, but up to now NO remained a prime suspect for the pathogenesis of the cardiovascular shock.

The team in Ghent is turning this paradigm upside-down in an article that will appear in The Journal of Experimental Medicine on Monday 21 December 2009. During their research, Cauwels and Brouckaert administered nitrite − a substance that releases NO − to mice with septic shock. The nitrite treatment, in sharp contrast with the worsening effect of inhibiting NO-synthesis, significantly attenuates hypothermia, mitochondrial damage, o
'/>"/>

Contact: Joris Gansemans
joris.gansemans@vib.be
329-244-6611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Immune system protein accurate predictor of survival in pediatric septic shock
2. CEL-SCI Corporation to Launch Aseptic Filling for Stem Cell Produced Therapies and Other Biological Products
3. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
4. Elevated nitric oxide in blood is key to high altitude function for Tibetans
5. Nitric oxide regulates plants as well as people
6. Mice use specialized neurons to detect carbon dioxide in the air
7. New membrane strips carbon dioxide from natural gas faster and better
8. US fires release large amounts of carbon dioxide
9. Nitrous oxide from ocean microbes
10. Food source threatened by carbon dioxide
11. New model revises estimates of terrestrial carbon dioxide uptake
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... , June 27, 2014  Pomerantz LLP has ... Inc. ("Provectus" or the "Company")(NYSE-MKT: PVCT) and certain ... United States District Court, Middle District of ... behalf of a class consisting of all persons ... securities between December 17, 2013 and May 22, ...
(Date:7/10/2014)... NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication company focused on the growing ... was interviewed on July 1 st on the Downtown ... Mr. Pereira discusses the company,s next generation smart wallet with ... Wocket™ aims to replace a traditional wallet with a new ... tells Gino he has never heard of the Wocket and ...
(Date:7/10/2014)... July 8, 2014 Fingerprint ... new design win (DW). An Asian OEM has selected FPC1021 ... production start in August 2014.   FPC is ... which has a planned date for start of mass production ... order of SEK 5M, for delivery in the first half ...
Breaking Biology News(10 mins):SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 2Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 4FPC Wins DW and Initial Ramp Order for FPC1021 Touch Sensor for Flagship Smartphone from Asian OEM 2
... injuries have difficulty developing story-telling skills even though other ... with other children as they mature, research at the ... there may be limitations to the remarkable flexibility for ... zlem Ece Demir, a researcher at the University of ...
... migration to and from Mexico complete an even more ... from the University of Guelph reveals that some North American ... east over the Appalachians and settle along the eastern seaboard. ... north directly from the Gulf coast. The study ...
... our hearts and blood vessels. Conventional treatment attempts to ... the blood plasma. The opposite approach, which involves increasing ... has proven unpopular among patients up to now. The ... has an unpleasant but harmless side-effect: the drug ...
Cached Biology News:Children with brain injuries have problems with story-telling 2U of G research reveals how monarchs fly away home 2Preventing heart problems while keeping a cool head 2Preventing heart problems while keeping a cool head 3
(Date:7/11/2014)... July 11, 2014 Cayenne Medical, ... specializing in the soft tissue reconstruction segment, announced ... System for surgeries involving the shoulder and extremities. ... a novel, inserter-controlled deployment method. The unique delivery ... deployment, anchor pull-out, or anchor displacement (also commonly ...
(Date:7/10/2014)... 10, 2014 Deep Knowledge Ventures ... Forum on ‘Commercialising Longevity Research’ and welcomed a ... the London Bioscience Innovation Center for the event, ... Aging Analytics Ltd. The meeting highlighted the need ... research for age-related disease, as well as the ...
(Date:7/10/2014)... (PRWEB) July 10, 2014 Unraveling life’s ... together. The Archer Family purchased a DNA ... DNA, but ended up with a lifetime of memories, ... within the family members’ DNA genuinely brought the family ... to search deeper into genetic history and prior to ...
(Date:7/10/2014)... EvoDerma ’s NOOME Anti-Aging Motion has been ... comes with a second treatment cup to help prevent and ... cup is thinner on the edges for a softer contact ... and uneven surfaces on the face, neck and décolleté. Choose ... on areas such as the cheeks and neck, or opt ...
Breaking Biology Technology:Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 2Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 2DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 4DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 5DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 6Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion 2
... Case Western Reserve University Biomedical Engineering Department has set ... and the aged, the critically ill and traumatically injured. ... as it celebrates its 40th anniversary, Thursday, Oct. 22. ... in the nation to offer graduate and undergraduate biomedical ...
... International is pleased to announce that the United States ... 7,604,929 to Celsis In Vitro Technologies (Celsis IVT). ... creates its unique LiverPool(TM) products for drug discovery research. ... to create large lots with targeted activity levels. The ...
... The Colorado Center for Reproductive Medicine (CCRM) announced today a ... vitro fertilization (IVF) with comprehensive chromosome screening (CCS), an ongoing ... about 30% worldwide. , In May of 2007, CCRM ... of chromosomes in a few cells removed from the embryo ...
Cached Biology Technology:40 Years on the Leading Edge: Case Western Reserve University's Biomedical Engineering Department Commemorates Achievement, Looks to Future 2Celsis IVT Granted U.S. Patent for LiverPool(TM) Hepatocytes 2Colorado Center for Reproductive Medicine Improves Pregnancy and Implantation Rates Using Comprehensive Chromosomal Screening of IVF Embryos 2Colorado Center for Reproductive Medicine Improves Pregnancy and Implantation Rates Using Comprehensive Chromosomal Screening of IVF Embryos 3
ID clarifier: platform...
... Engine Tetrad 2 thermal cycler accommodates ... (sample-holder, heat-pump assemblies), which hold different ... Pentium-class computer drives an advanced graphical ... and lid temperatures. Peltier heat pumps, ...
4',6-Diamidino-2-phenylindole, dihydrochloride (DAPI)...
... the drug discovery process in mind. Due ... Safire is the ideal instrument to bridge ... throughput screening. Safire is a fully modular ... range of high speed detection techniques. In ...
Biology Products: