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September 2008 Biology of Reproduction highlights
Date:8/19/2008

torcycles circulating daily on the main street of this intersection. Pregnant mice exposed to urban air pollution either before or during gestation produced fetuses of smaller weights compared to those provided filtered air. In addition, the effects of urban air pollution were found to be due to adaptive changes in placental development that ultimately reduce placental function and compromise fetal growth. This is a novel model to dissect the mechanisms of how specific pollutants influence development of the placenta and fetus. These findings are important with respect to the possible transplacental transfer of pollutants from mother to fetus as well as fetal programming and developmental origins of health and disease in adults.

Mariana Matera Veras, Nilsa Regina Damaceno-Rodrigues, Elia Garcia Caldini, Antonio A.C. Maciel Ribeiro, Terry M. Mayhew, Paulo H.N. Saldiva, and Marisa Dolhnikoff.
Particulate Urban Air Pollution Affects the Functional Morphology of Mouse Placenta.
Biol Reprod 2008; 79:578-584. Published online in BOR-Papers In Press 28 May 2008; DOI 10.1095/biolreprod.108.069591


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Contact: Judith Jansen
ssradmin@ssr.org
608-256-2777
Society for the Study of Reproduction
Source:Eurekalert

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