Navigation Links
September 2008 Biology of Reproduction highlights
Date:8/19/2008

Proteomes to unravel gonadotrophs

Although the basic developmental lineage of pituitary gonadotrophs is known, it has been harder to associate specific changes in gene expression with maturation due to the limited cell population. In an article on p. 546 of the September 2008 issue of Biology of Reproduction, Feng et al. take the approach of comparing the nuclear proteome of two gonadotropic cell lines that were immortalized at different stages of development. Their results demonstrate changes in proteins that reflect regulatory control of transcription and post-transcriptional processing, thus laying a framework to guide experimental analysis of the complex sequelae of events that lead to mature gonadotropic function in animals.

Jiajun Feng, Mark A. Lawson, and Philippa Melamed.
A Proteomic Comparison of Immature and Mature Gonadotrophs in Mice Reveals Novel Differentially Expressed Nuclear Proteins That Regulate Gonadotropin Gene Transcription and RNA Splicing.
Biol Reprod 2008; 79:546-561. Published online in BOR-Papers In Press 14 May 2008; DOI 10.1095/biolreprod.108.068106


Pollution and placenta

Urban air pollution is associated with poor and adverse pregnancy outcomes, including low birthweight, premature birth, and intrauterine growth retardation. In a paper on p. 578 of the September 2008 issue of Biology of Reproduction, Veras and coworkers present evidence that the effects of urban air pollution on pregnancy outcomes could be related to changes in functional morphology of the placenta. The experiments employed a novel approach in which pregnant female mice were exposed before or during gestation to filtered or nonfiltered air in exposure chambers placed in the garden of the University of Sao Paulo School of Medicine in Brazil. The garden is situated close to a crossroads with high traffic density with about 83,900 cars, 9,900 diesel vehicles, and 6,300 motorcycles circulating daily on the main street of this intersection. Pregnant mice exposed to urban air pollution either before or during gestation produced fetuses of smaller weights compared to those provided filtered air. In addition, the effects of urban air pollution were found to be due to adaptive changes in placental development that ultimately reduce placental function and compromise fetal growth. This is a novel model to dissect the mechanisms of how specific pollutants influence development of the placenta and fetus. These findings are important with respect to the possible transplacental transfer of pollutants from mother to fetus as well as fetal programming and developmental origins of health and disease in adults.

Mariana Matera Veras, Nilsa Regina Damaceno-Rodrigues, Elia Garcia Caldini, Antonio A.C. Maciel Ribeiro, Terry M. Mayhew, Paulo H.N. Saldiva, and Marisa Dolhnikoff.
Particulate Urban Air Pollution Affects the Functional Morphology of Mouse Placenta.
Biol Reprod 2008; 79:578-584. Published online in BOR-Papers In Press 28 May 2008; DOI 10.1095/biolreprod.108.069591


'/>"/>

Contact: Judith Jansen
ssradmin@ssr.org
608-256-2777
Society for the Study of Reproduction
Source:Eurekalert

Related biology news :

1. Story tips from the US Department of Energys Oak Ridge National Laboratory, September 2007
2. Highlights from the September 2007 Journal of the American Dietetic Association
3. September Geology and GSA Today media highlights
4. $3.2M for Rutgers to apply biology, engineering, physical sciences toward stem cells
5. Bringing Martian samples to Earth -- preparations outlined in journal Astrobiology
6. Structural biology spin-out tackles major diseases
7. Cold Spring Harbor Protocols highlights gene silencing, cancer cell biology methods
8. Tips from the Journals of the American Society for Microbiology
9. American Society for Microbiology honors Victor de Lorenzo
10. American Society for Microbiology honors Katharine R. Clapham
11. American Society for Microbiology honors Stephen C. Edberg
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2016)... , January 22, 2016 ... the addition of the  "Global Behavioral ... offering. --> http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) ... "Global Behavioral Biometric Market 2016-2020"  report ... Research and Markets ( http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has ...
(Date:1/20/2016)... , Jan. 20, 2016   MedNet Solutions , ... entire spectrum of clinical research, is pleased to announce ... significant achievements are the result of the company,s laser ... iMedNet eClinical , it,s comprehensive, easy-to-use and highly ... --> Key MedNet growth achievements in 2015 ...
(Date:1/13/2016)... , January 13, 2016 ... has published a new market report titled - Biometric Sensors ... and Forecast, 2015 - 2023. According to the report, the global ... and is anticipated to reach US$1,625.8 mn by 2023, ... 2023. In terms of volume, the biometric sensors market ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... DUBLIN , Feb. 10, 2016  Allergan plc ... today announced that Brent Saunders , Allergan,s CEO ... in a fireside chat session at the RBC Capital ... 12:30 p.m. ET at The New York Palace Hotel ... presentation will be webcast live and can be accessed ...
(Date:2/10/2016)... ... February 10, 2016 , ... SonaCare ... training and support program, Sonalinkā„¢ remote monitoring. The inaugural launch of this new ... February 5th, connecting Dr. Samuel Peretsman to a HIFU technical expert at SonaCare ...
(Date:2/10/2016)... , ... February 09, 2016 , ... ... and current winner of the Highest Overall Customer Rating Award from Circuits ... of its business units across the USA, Canada, Mexico and China. , The ...
(Date:2/9/2016)... ... February 09, 2016 , ... ... its free and validated Electronic Data Capture (EDC) system ClinCaptureand its new Contract ... Trials West Coast 2016 Conference in San Mateo, California on February 10th and ...
Breaking Biology Technology: