Navigation Links
Sensitive nanowire disease detectors made by Yale scientists

New Haven, Conn. Yale scientists have created nanowire sensors coupled with simple microprocessor electronics that are both sensitive and specific enough to be used for point-of-care (POC) disease detection, according to a report in Nano Letters.

The sensors use activation of immune cells by highly specific antigens signatures of bacteria, viruses or cancer cells as the detector. When T cells are activated, they produce acid, and generate a tiny current in the nanowire electronics, signaling the presence of a specific antigen. The system can detect as few as 200 activated cells.

In earlier studies, these researchers demonstrated that the nanowires could detect generalized activation of this small number of T cells. The new report expands that work and shows the nanowires can identify activation from a single specific antigen even when there is substantial background "noise" from a general immune stimulation of other cells.

Describing the sensitivity of the system, senior author Tarek Fahmy, Yale assistant professor of biomedical engineering, said:. "Imagine I am the detector in a room where thousands of unrelated people are talking and I whisper, 'Who knows me?' I am so sensitive that I can hear even a few people saying, 'I do' above the crowd noise. In the past, we could detect everyone talking now we can hear the few above the many."

According to the authors, this level of sensitivity and specificity is unprecedented in a system that uses no dyes or radioactivity. Beyond its sensitivity, they say, the beauty of this detection system is in its speed producing results in seconds and its compatibility with existing CMOS electronics.

"We simply took direction from Mother Nature and used the exquisitely sensitive and flexible detection of the immune system as the detector, and a basic physiological response of immune cells as the reporter," said postdoctoral fellow and lead author, Eric Stern. "We coupled that with existing CMOS electronics to make it easily usable."

The authors see a huge potential for the system in POC diagnostic centers in the US and in underdeveloped countries where healthcare facilities and clinics are lacking. He says it could be as simple as an iPod-like device with changeable cards to detect or diagnose disease. Importantly, Stern notes that the system produces no false positives a necessity for POC testing.

The authors suggest that in a clinic, assays could immediately determine which strain of flu a patient has, whether or not there is an HIV infection, or what strain of tuberculosis or coli bacteria is present. Currently, there are no electronic POC diagnostic devices available for disease detection. "Instruments this sensitive could also play a role in detection of residual disease after antiviral treatments or chemotherapy," said Fahmy. "They will help with one of the greatest challenges we face in treatment of disease knowing if we got rid of all of it."


Contact: Janet Rettig Emanuel
Yale University

Related biology news :

1. For insulin sensitive overweight patients, 1 session of exercise improves metabolic health
2. More sensitive radiology monitoring in the Basque Country
3. Researchers develop new ultrasensitive assay to detect most poisonous substance known
4. New chemically-sensitive MRI scan may bypass some invasive diagnostic tests in next decade
5. Nanowires hold promise for more affordable solar cells
6. Stanfords nanowire battery holds 10 times the charge of existing ones
7. Waterborne disease risk upped in Great Lakes
8. Tracking down the cause of mad cow disease
9. LSUHSC awarded patent for compound inhibiting cancer and other diseases
10. Form of Crohns disease traced to disabled gut cells
11. World leaders in infectious diseases convene to discuss emerging global viruses
Post Your Comments:
(Date:5/16/2016)... YORK , May 16, 2016   EyeLock ... solutions, today announced the opening of an IoT Center ... to strengthen and expand the development of embedded iris ... an unprecedented level of convenience and security with unmatched ... authenticate one,s identity aside from DNA. EyeLock,s platform uses ...
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 /PRNewswire/ ... product subsidiary of Infosys (NYSE: INFY ), and ... global partnership that will provide end customers with ... banking and payment services.      (Logo: ... area for financial services, but it also plays a fundamental ...
(Date:4/19/2016)... 2016 The new GEZE SecuLogic ... web-based "all-in-one" system solution for all door components. It ... the door interface with integration authorization management system, and ... The minimal dimensions of the access control and the ... installations offer considerable freedom of design with regard to ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... NC (PRWEB) , ... June 27, 2016 , ... ... just published their findings on what they believe could be a new and ... of the new research. Click here to read it now. , ...
(Date:6/27/2016)... BOSTON , June 27, 2016   Ginkgo ... biology to industrial engineering, was today awarded as ... a selection of the world,s most innovative companies. ... at scale for the real world in the ... organism engineers work directly with customers including Fortune ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... release of its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering ... retention in this eBook by providing practical tips, tools, and strategies for clinical ...
(Date:6/23/2016)... , June 23, 2016 Houston ... with the Cy-Fair Sports Association to serve as ... the agreement, Houston Methodist Willowbrook will provide sponsorship ... and connectivity with association coaches, volunteers, athletes and ... with the Cy-Fair Sports Association and to bring ...
Breaking Biology Technology: