Navigation Links
Sensitive nanowire disease detectors made by Yale scientists
Date:10/10/2008

New Haven, Conn. Yale scientists have created nanowire sensors coupled with simple microprocessor electronics that are both sensitive and specific enough to be used for point-of-care (POC) disease detection, according to a report in Nano Letters.

The sensors use activation of immune cells by highly specific antigens signatures of bacteria, viruses or cancer cells as the detector. When T cells are activated, they produce acid, and generate a tiny current in the nanowire electronics, signaling the presence of a specific antigen. The system can detect as few as 200 activated cells.

In earlier studies, these researchers demonstrated that the nanowires could detect generalized activation of this small number of T cells. The new report expands that work and shows the nanowires can identify activation from a single specific antigen even when there is substantial background "noise" from a general immune stimulation of other cells.

Describing the sensitivity of the system, senior author Tarek Fahmy, Yale assistant professor of biomedical engineering, said:. "Imagine I am the detector in a room where thousands of unrelated people are talking and I whisper, 'Who knows me?' I am so sensitive that I can hear even a few people saying, 'I do' above the crowd noise. In the past, we could detect everyone talking now we can hear the few above the many."

According to the authors, this level of sensitivity and specificity is unprecedented in a system that uses no dyes or radioactivity. Beyond its sensitivity, they say, the beauty of this detection system is in its speed producing results in seconds and its compatibility with existing CMOS electronics.

"We simply took direction from Mother Nature and used the exquisitely s
'/>"/>

Contact: Janet Rettig Emanuel
janet.emanuel@yale.edu
203-432-2157
Yale University
Source:Eurekalert

Page: 1 2

Related biology news :

1. For insulin sensitive overweight patients, 1 session of exercise improves metabolic health
2. More sensitive radiology monitoring in the Basque Country
3. Researchers develop new ultrasensitive assay to detect most poisonous substance known
4. New chemically-sensitive MRI scan may bypass some invasive diagnostic tests in next decade
5. Nanowires hold promise for more affordable solar cells
6. Stanfords nanowire battery holds 10 times the charge of existing ones
7. Waterborne disease risk upped in Great Lakes
8. Tracking down the cause of mad cow disease
9. LSUHSC awarded patent for compound inhibiting cancer and other diseases
10. Form of Crohns disease traced to disabled gut cells
11. World leaders in infectious diseases convene to discuss emerging global viruses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... burning is published today in the first authoritative scientific ... tensions on both sides of the grouse moor management ... on the Ecohydrology of River basins) project has shown ... to support red grouse populations for gun sports, has ... physical properties, river water chemistry and river ecology. , ...
(Date:9/30/2014)... salmon, and strawberries all have in common? Unlike ... chromosomes and are diploid, these organisms are all polyploid, ... watermelon and salmon have 3 and 4 sets of ... might seem surprising, in fact most plant species are ... a century ago, but only recently, with the development ...
(Date:9/30/2014)... team of environmental scientists and engineers, led by ... a three-year, $5.25 million grant from the U.S. ... Research to make a direct positive impact on ... and disposal of radioactive contaminants. , "Understanding the ... dealing with environmental aspects of nuclear technologies is ...
Breaking Biology News(10 mins):Grouse moor burning causes widespread environmental changes 2Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 2Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 3Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 4Researchers get $5.25 million to advance nuclear technologies in South Carolina 2
... 26, 2012   Goldfarb LLP is investigating whether ... (OTC: AOBI) violated shareholder protection laws as evidenced through ... investors who purchased stock before June 15, 2012 are ... hlindley@goldfarbllp.com about their rights and remedies. ...
... have invented a new toilet system that will turn human ... of water needed for flushing by up to 90 per ... the No-Mix Vacuum Toilet, it has two chambers that separate ... as those used in aircraft lavatories, flushing liquids would now ...
... study from more than 60 years ago suggesting that males ... may, in fact, be wrong, say life scientists who are ... methods as the original. In 1948, English ... fruit flies gain an evolutionary advantage from having multiple mates, ...
Cached Biology News:NTU's new loo turns poo into power 2NTU's new loo turns poo into power 3UCLA biologists reveal potential 'fatal flaw' in iconic sexual selection study 2UCLA biologists reveal potential 'fatal flaw' in iconic sexual selection study 3UCLA biologists reveal potential 'fatal flaw' in iconic sexual selection study 4UCLA biologists reveal potential 'fatal flaw' in iconic sexual selection study 5
(Date:10/1/2014)... Slone Partners , a national recruitment ... Laboratory Testing industries, reported a 120% increase in placements ... and above from July 2013 to July 2014. ... rapid breakthroughs in diagnostics, reimbursement has failed to keep ... forced to fold, consolidate, or carry on without payment ...
(Date:9/30/2014)... German . , The ... a semiconductor layer. Quantum dots are small structures that spontaneously ... short laser pulse is fired at the photonic crystal, its ... change in the electromagnetic field around it. This change can ... the dot. As soon as the refractive index recovers its ...
(Date:9/30/2014)... NEW YORK , Sept. 30, 2014 /PRNewswire/ ... trends and segments with highest potential revenues Do ... Visiongain,s updated report gives you revenue predictions for ... ahead. For those therapies you find financial data, ... new analysis you get sales forecasts to 2024 ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 Follow ... level of each type of cholesterol carrier or lipoprotein ... presence of excessive cholesterol levels in the body, especially ... condition to heart attack and other cardiovascular disorders. Cardiovascular ... therefore testing for cholesterol levels on a regular basis, ...
Breaking Biology Technology:Slone Partners Meets Growing Demand as Industry Focuses on Reimbursement & Regulation 2Ultrafast remote switching of light emission 2Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 2Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 3Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 4Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 5Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 2Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 3Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 4
... has reaffirmed its support for stem cell research - ... ,Illinois Gov. Rod Blagojevich last week announced that Illinois ... stem cell research. The announcement makes Illinois the fourth ... after New Jersey, California and Connecticut. , ,The ...
... Sonic Foundry announced on Monday that Darrin ... be promoted to senior vice president of worldwide field ... the company's Mediasite applications. , ,Prior to joining Sonic ... Americas Enterprise Business division and executive vice president of ...
... Wis. - When Milwaukee-based coffee chain Stone ... the company chose an emerging tool to enhance customer ... company's technology and marketing director, the blog can bring ... that goes beyond mere press releases or other traditional ...
Cached Biology Technology:Illinois stem cell funding could aid issue's visibility 2Business blogs increase customer interactions 2Business blogs increase customer interactions 3Business blogs increase customer interactions 4Business blogs increase customer interactions 5
... fume hood ventilates and purifies ... release of exhaust. Bonded charcoal ... Configurations are available with vertical ... final HEPA filter, work bench ...
Sigmas E-TOXATE (Limulus Amebocyte Lysate) test kits are intended for the detection and semiquantitation,of endotoxins for research purposes....
...
... enclosures are designed for ... other process gas to ... HEPA filtration, heating/cooling, humidification, ... also available, along with ...
Biology Products: