Navigation Links
Self-organized pituitary-like tissue from mouse ES cells
Date:11/14/2011

d the first tantalizing insights into the developmental capacity of pluripotent stem cells, showing their ability to give rise to multi-cell-type populations of cortical and retinal neurons that spontaneously self-organize into stratified tissue nearly identical to that of the developing embryo.

In the group's most recent work, Suga sought to use SFEBq to derive the secretory component of the pituitary (hypophysis) from mouse ES cells. In embryonic development, the pituitary emerges from a region of the non-neural (rostral) head ectoderm, adjacent to the anterior neural plate. Guided by molecular interactions, this placodal region forms an indentation, known as Rathke's pouch, in the developmental predecessor of the roof of the mouth, and eventually gives rise to the anterior section of the pituitary, the source of hormones involved in growth, reproduction and modulating the physiological response to stress.

The Sasai lab had previously reported how a modified version of the SFEBq approach lacking extrinsic growth factors could spur ES cells to give rise to hypothalamic neurons. Building on this finding, Suga found by further tweaking the conditions he could steer populations of such stem cells to differentiate simultaneously into the neighboring rostral head ectoderm and hypothalamic neuroectoderm, both of which are required to development of the adenohypophysis. Interestingly, the cells in these clusters spontaneously organized into distinct layers resembling those of the corresponding embryonic tissues. This effect appears to be attributable to the increase of BMP signaling in larger cell aggregates, leading to differentiation into non-neural ectoderm. To test whether co-culture of this ectoderm with hypothalamic tissue would lead to the formation of Rathke's pouch-like structures, Suga observed the ESC-derived aggregates for nearly two weeks, and found that by adding the signaling factor Sonic hedgehog, he was able to induce the self-directed
'/>"/>

Contact: Douglas Sipp
sipp@cdb.riken.jp
RIKEN
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Tufts University researcher develops living tissue
2. Manufacturing microscale medical devices for faster tissue engineering
3. New composite material may restore damaged soft tissue
4. Study shows answers for treating obesity-related diseases may reside in fat tissue
5. More than bacon: Genetic alterations in pig tissue may allow for human transplantation
6. IADR/AADR publish proceedings from Symposium on Tissue Injury and Pulp Regeneration
7. Progress in tissue engineering to repair joint damage in osteoarthritis
8. Yale scientists discover new method for engineering human tissue regeneration
9. Extracting stem cells from fat for tissue regeneration
10. Repulsion more important than cohesion in embryonic tissue separation
11. Molecular muscle: Small parts of a big protein play key roles in building tissues
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... , Aug. 20, 2014 /CNW/ -  Issue ... warning and can quickly become life threatening for some children. ... many as 1.2 million Canadians have food allergies and this ... per cent of children are estimated to have food allergies.  ... from mild skin irritations and hives to breathing difficulties and ...
(Date:8/20/2014)... University, the Wellcome Trust Sanger Institute and the Swiss ... Mycobacterium pinnipedii from skeletons found in Peru which ... a relative of the TB bacterium that affects seals ... researchers assume that seals carried the pathogens from Africa ... was unexpected" comments Sebastien Gagneux, from the Swiss Tropical ...
(Date:8/20/2014)... are visible in in this image of the Para ... these were most likely intentionally set in order to ... forest or stand of trees where the land is ... include conversion of forestland to farms, ranches, or urban ... green of the Amazon Rainforest in the middle of ...
Breaking Biology News(10 mins):Information Update - Allergens and food safety at school - What's in your child's lunch? 2Information Update - Allergens and food safety at school - What's in your child's lunch? 3
... researchers are among a select group of scientists from ... National Cancer Institute (NCI) for their quest to answer ... Professor and Chair of Oncological Sciences and Ross Cagan, ... received the NCI,s new "Provocative Questions" grant, which was ...
... 2012 Novetta Solutions, LLC (Novetta), a portfolio ... acquisition of International Biometric Group, LLC (IBG). Novetta ... within the National Security community and other organizations ... established in March 2012 through the merger of ...
... can play a key role in feeding people and restoring their ... during their little-known involvement in the liberation of Bergen-Belsen at the ... a historical research paper published in the October issue of the ... been written about the role of the armed forces and medical ...
Cached Biology News:Mount Sinai researchers awarded 'Provocative Questions' grant from National Cancer Institute 2Mount Sinai researchers awarded 'Provocative Questions' grant from National Cancer Institute 3Novetta Solutions Acquires International Biometric Group, LLC 2Novetta Solutions Acquires International Biometric Group, LLC 3Bergen-Belsen lessons underline vital role that nurses can play in patient feeding 2Bergen-Belsen lessons underline vital role that nurses can play in patient feeding 3
(Date:8/20/2014)... California (PRWEB) August 20, 2014 ... develop and apply the most complete climate and ... and demanding climate change issues. , Eight national ... forces with the National Center for Atmospheric Research, ... the new effort. Other participating national laboratories include ...
(Date:8/20/2014)... 20, 2014  PAREXEL International Corporation (NASDAQ: ... at the Baird Healthcare Conference in New York.  ... Officer, will be making a presentation on PAREXEL and ... Sept. 3, 2014. A live webcast of ... of PAREXEL,s website at www.PAREXEL.com in the ...
(Date:8/20/2014)... Not long ago, it was more or ... late in the development cycle – even after the ... suggest that, like many things GxP, expectations for early ... multiple drug sponsors have been required by authorities to ... phase I/II. It’s not only clinical trial material containers ...
(Date:8/20/2014)... could improve the health of your heart, researchers have ... used a standard TENS machine like those designed to ... tragus, the small raised flap at the front of ... , The stimulation changed the influence of the nervous ... that can drive failing hearts too hard. , Professor ...
Breaking Biology Technology:New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 3PAREXEL International To Present At Baird Healthcare Conference 2Are Extractable and Leachables going Phase-Appropriate? New Webinar Hosted by Xtalks 2'Tickling' your ear could be good for your heart 2
... Institute of Standards and Technology (NIST) may have ... of computer memory now under development. The work, ... University (GMU), aims to optimize nanowire-based charge-trapping memory ... computers and cell phones that can operate for ...
... DIEGO, May 25, 2011 Anadys Pharmaceuticals, Inc. (Nasdaq: ... for the treatment of hepatitis C, announced today that it ... ANA773, the Company,s oral immuno-modulator that acts via the TLR-7 ... Annual Meeting in Chicago, IL.  The data from the completed ...
... 2011 WaferGen Biosystems, Inc. (OTCBB:WGBS), a leading ... it has entered into definitive agreements with three ... LLC, Deerfield Management and Merlin Nexus, and certain ... $30.4 million private placement financing of equity and ...
Cached Biology Technology:NIST 'nanowire' measurements could improve computer memory 2Anadys Highlights ANA773 Data to be Presented at ASCO 2Anadys Highlights ANA773 Data to be Presented at ASCO 3Anadys Highlights ANA773 Data to be Presented at ASCO 4WaferGen Announces $30 Million Financing 2WaferGen Announces $30 Million Financing 3WaferGen Announces $30 Million Financing 4
... 94kDa ultra-pure recombinant thermostable DNA polymerase obtained ... DNA polymerase gene in E. coli, Concentration: ... of Thermo Fisher Scientific, the world leader ... customers to make the world healthier, cleaner ...
ABgene® supplies a 94kDa ultra-pure recombinant thermostable DNA polymerase obtained by high level expression of the Taq DNA polymerase gene in E. coli....
Collected at a certified USDA establishment located within the United States. All final processing is done by Quad Five employees....
... is a thermostable DNA polymerase derived ... at temperatures above 70°C, it was ... PCR and remains the predominant enzyme ... an intrinsic 5'?3' structure-dependent exonuclease activity, ...
Biology Products: