Navigation Links
Self-organized pituitary-like tissue from mouse ES cells
Date:11/14/2011

d the first tantalizing insights into the developmental capacity of pluripotent stem cells, showing their ability to give rise to multi-cell-type populations of cortical and retinal neurons that spontaneously self-organize into stratified tissue nearly identical to that of the developing embryo.

In the group's most recent work, Suga sought to use SFEBq to derive the secretory component of the pituitary (hypophysis) from mouse ES cells. In embryonic development, the pituitary emerges from a region of the non-neural (rostral) head ectoderm, adjacent to the anterior neural plate. Guided by molecular interactions, this placodal region forms an indentation, known as Rathke's pouch, in the developmental predecessor of the roof of the mouth, and eventually gives rise to the anterior section of the pituitary, the source of hormones involved in growth, reproduction and modulating the physiological response to stress.

The Sasai lab had previously reported how a modified version of the SFEBq approach lacking extrinsic growth factors could spur ES cells to give rise to hypothalamic neurons. Building on this finding, Suga found by further tweaking the conditions he could steer populations of such stem cells to differentiate simultaneously into the neighboring rostral head ectoderm and hypothalamic neuroectoderm, both of which are required to development of the adenohypophysis. Interestingly, the cells in these clusters spontaneously organized into distinct layers resembling those of the corresponding embryonic tissues. This effect appears to be attributable to the increase of BMP signaling in larger cell aggregates, leading to differentiation into non-neural ectoderm. To test whether co-culture of this ectoderm with hypothalamic tissue would lead to the formation of Rathke's pouch-like structures, Suga observed the ESC-derived aggregates for nearly two weeks, and found that by adding the signaling factor Sonic hedgehog, he was able to induce the self-directed
'/>"/>

Contact: Douglas Sipp
sipp@cdb.riken.jp
RIKEN
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Tufts University researcher develops living tissue
2. Manufacturing microscale medical devices for faster tissue engineering
3. New composite material may restore damaged soft tissue
4. Study shows answers for treating obesity-related diseases may reside in fat tissue
5. More than bacon: Genetic alterations in pig tissue may allow for human transplantation
6. IADR/AADR publish proceedings from Symposium on Tissue Injury and Pulp Regeneration
7. Progress in tissue engineering to repair joint damage in osteoarthritis
8. Yale scientists discover new method for engineering human tissue regeneration
9. Extracting stem cells from fat for tissue regeneration
10. Repulsion more important than cohesion in embryonic tissue separation
11. Molecular muscle: Small parts of a big protein play key roles in building tissues
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... Dec. 18, 2014   LaunchKey , the first decentralized ... and Internet of Things era, today announced the close ... round was led by Metamorphic Ventures with participation from ... VegasTechFund, and others.  LaunchKey has raised $4 million to ...
(Date:12/17/2014)... Dec. 15, 2014  HITLAB SM announced today its ... confirm its adherence to current U.S. Food and Drug ... regulated smart device and smart phone application trials utilizing ... "HITLAB is determined to improve global healthcare ...
(Date:12/17/2014)... fundamentally transforming the travel experience and nowhere is this ... decade, ePassports, biometric readers, and secure document scanners have ... via eGates and Automated Passport Control (APC) Kiosks at ... across the globe. According to ...
Breaking Biology News(10 mins):LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2
... the skeletons of organisms contain small amounts of impurity ... elements provide important clues to past environments, a considerable ... contents to the ancient environments in which an organism ... Science magazine, Allison Stephenson, a Ph.D. candidate ...
... of the mystery underlying a childhood eye disease. New research ... missing or extra pieces of DNA. The missing or extra ... of A research team had previously shown how they play a ... disease that can lead to blindness. In their current study, published ...
... not food allergies at all. This is what Cornelia ... in a study with 419 patients, as presented in ... (Dtsch Arztebl Int 2008; 105[42]: 715-23). http://www.aerzteblatt.de/v4/archiv/pdf.asp?id=61998 ... only confirmed in 214 patients. Thus, food allergies are ...
Cached Biology News:Bare bones of crystal growth: Biomolecules enhance metal contents in calcite 2
(Date:1/22/2015)... 2015  Transwestern | RBJ today announces the firm brokered a ... Shire a leading biopharmaceutical company, at Two Ledgemont Center in ... Robert Richards , president, and Brian Cohen , senior ... five-floor building at 95 Hayden Ave. Photo - ...
(Date:1/22/2015)... 22, 2015 Protocol Networks brings independent ... team of brand-neutral, independent consultants, Protocol Networks has recently ... that over the years, his company has attracted several ... of Plainfield, as well as others. With the success ...
(Date:1/22/2015)... January 22, 2015 Controlled Substance Compliance ... which helps companies check the legal requirements around using ... to China. , As their international operations expand ... adopting software solutions built as a result of the ...
(Date:1/22/2015)... Calif. , Jan. 22. 2015  Varian Medical Systems (NYSE: ... software, has been honored for its commitment to sustainability with ... companies. Varian is the highest ranked healthcare equipment company among ... today during the World Economic Forum at Davos, ...
Breaking Biology Technology:Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Protocol Networks Brings Independent Technology Consulting to the Constitution State 2Global Compliance Service for Controlled Substances to Expand to China 2Varian Honored Among World's 100 Most Sustainable Corporations 2
... Calif., Aug. 31 Raptor Pharmaceuticals Corp. ("Raptor" or the "Company") ... 2009 Annual Meeting of Stockholders on Monday, September 28, 2009 at ... Blvd., Suite 200, Novato, California. All stockholders of record as of ... meeting and all stockholders of Raptor are invited to attend such ...
... , , , ... 31 Rib-X Pharmaceuticals, Inc. ("Rib-X" or the "Company"), a ... novel antibiotics for the treatment of acute care antibiotic-resistant infections, ... several computationally designed series of chemically unique compounds demonstrating efficacy ...
... , , , ... BioLife Solutions, Inc. (OTC Bulletin Board: BLFS), a leading developer, ... organs, today announced the launch of its BloodStor biopreservation media ... cryopreservation of umbilical cord blood stem cells, as well as ...
Cached Biology Technology:Raptor Pharmaceuticals Schedules 2009 Annual Meeting of Stockholders 2Raptor Pharmaceuticals Schedules 2009 Annual Meeting of Stockholders 3Rib-X Pharmaceuticals Antibiotic Drug Discovery Platform Discovers Novel Compounds with Activity Against Key Multiple Drug Resistant Gram-negative Bacteria 2Rib-X Pharmaceuticals Antibiotic Drug Discovery Platform Discovers Novel Compounds with Activity Against Key Multiple Drug Resistant Gram-negative Bacteria 3BloodStor(TM) Stem Cell Biopreservation Media Platform Launched by BioLife Solutions 2BloodStor(TM) Stem Cell Biopreservation Media Platform Launched by BioLife Solutions 3
... PEP-152 is a 17 amino acid synthetic peptide whose sequence is ... (amino to carboxy terminus): C - N(217) - Q - ... - A - T - P - N - Y - ... may be used for neutralization and control experiments with the polyclonal ...
... a novel target for which no antibody exists? ... custom antibodies for a variety of pharmaceutical, biotech ... to put our technology and expertise in antibody ... to our patented RabMAb development technology , High ...
... The Rapid-Screen cDNA Library Panels were ... just three sets of PCRs to identify ... analysis is performed in a 96-well "Master ... from 5,000 clones. Having identified the positive ...
... The Rapid-Screen cDNA Library Panels were ... just three sets of PCRs to identify ... analysis is performed in a 96-well "Master ... from 5,000 clones. Having identified the positive ...
Biology Products: