Navigation Links
Self-organized pituitary-like tissue from mouse ES cells
Date:11/14/2011

November 14, 2011 The possibility that functional, three-dimensional tissues and organs may be derived from pluripotent cells, such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), represents one of the grand challenges of stem cell research, but is also one of the fundamental goals of the emerging field of regenerative medicine. Developmental biology has played a central role in informing such efforts, as it has been shown that stem cell differentiation can be directed to follow a given lineage pathway by culturing stem cells in conditions that recapitulate the specific cellular and molecular environment from which such cells normally emerge during embryogenesis. Intriguingly, recent work has shown that when ES cells are cultured under the appropriate conditions, they can be driven to self-organize into complex, three-dimensional tissue-like structures that closely resemble their physiological counterparts, a remarkable advance for the field.

New work by Hidetaka Suga of the Division of Human Stem Cell Technology, Yoshiki Sasai, Group Director of the Laboratory for Organogenesis and Neurogenesis, and others has unlocked the most recent achievement in self-organized tissue differentiation, steering mouse ESCs to give rise to tissue closely resembling the hormone-secreting component of the pituitary, known as the adenohypophysis, in vitro. Conducted in collaboration with Yutaka Oiso at the Nagoya University Graduate School of Medicine, this work was published in Nature.

The Sasai group has complied an impressive list of achievements in induced differentiation using an ES cell culture technique dubbed SFEBq (shorthand for "serum-free floating culture of embryoid body-like aggregates with quick re-aggregation"), including high-efficiency methods for the differentiation of dopaminergic, cerebral cortex, cerebellar Purkinje, and other neuronal cell types. In recent years, refinements of this approach have enable
'/>"/>

Contact: Douglas Sipp
sipp@cdb.riken.jp
RIKEN
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Tufts University researcher develops living tissue
2. Manufacturing microscale medical devices for faster tissue engineering
3. New composite material may restore damaged soft tissue
4. Study shows answers for treating obesity-related diseases may reside in fat tissue
5. More than bacon: Genetic alterations in pig tissue may allow for human transplantation
6. IADR/AADR publish proceedings from Symposium on Tissue Injury and Pulp Regeneration
7. Progress in tissue engineering to repair joint damage in osteoarthritis
8. Yale scientists discover new method for engineering human tissue regeneration
9. Extracting stem cells from fat for tissue regeneration
10. Repulsion more important than cohesion in embryonic tissue separation
11. Molecular muscle: Small parts of a big protein play key roles in building tissues
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... (July 24, 2014)The link between autism and disrupted ... puzzle of the disease, and is largely unknown. ... Autism Research Initiative (SFARI), George Washington University (GW) ... offer truly integrative and in-depth answers to these ... , LaMantia, professor of pharmacology and physiology ...
(Date:7/25/2014)... from 25 countries and 35 states will attend ... Genetics Society of America (GSA) next week at ... will feature close to 500 presentations (including 70 ... gene expression and regulation, functional genomics, chemical biology ... a variety of diseases. , Of special ...
(Date:7/25/2014)... increasingly consume the healthcare community and remain ... , To address the worldwide crisis of ... countries, global leaders in diabetes, epidemiology and ... prevention and development of diverse intervention programs ... , This book on "Global Health Perspectives ...
Breaking Biology News(10 mins):GW researcher receives grant to answer the how and why of autism during development 2Yeast meeting to showcase latest breakthroughs in genetics and molecular biology 2What constitutes an effective response to the global 'diabesity' tsunami? 2
... available in French . , Researchers at McGill ... Jewish General Hospital along with colleagues at the University ... a significant breakthrough in the use of viruses to target ... Their results were published in the September early edition of ...
... Research today announced that Stuart A. Lipton, M.D., Ph.D., ... Aging, and Stem Cell Research Center at Burnham has ... a Center for Neurodegeneration Science (CNS). The center will ... the center comes from the National Institute of Environmental ...
... Innes Centre and the Central Science Laboratory could help ... stress and climate change. The research also shows that ... the climate. "While many compounds have been reported ... have identified how such compounds change in crops under ...
Cached Biology News:Viral 'magic bullet' targets cancer cells with help of new compound 2Burnham researcher awarded $8 million grant 2
(Date:7/25/2014)... MA -- Trillions of bacteria live in each person,s ... help digest food and stave off harmful infections, but ... , To help shed light on the role of ... associate professor Eric Alm recently tracked fluctuations in the ... year. The findings, described in the July 25 issue ...
(Date:7/25/2014)... (PRWEB) July 25, 2014 The Conferee ... for Topics for Conferee Networking. These two-hour sessions provide ... to meet and resolve problems, discuss new techniques, or ... deadline to submit a topic for consideration is August ... pittcon.org . The Conferee Networking committee will review the ...
(Date:7/25/2014)... Sinovac Biotech Ltd. (Nasdaq: SVA ), a leading ... today announced that it will release its unaudited financial results ... close on Thursday, August 14, 2014 EDT. The Company will ... Friday, August 15, 2014, at 8:00 a.m. EDT (Friday, August ... the Company,s financial results and provide an update on recent ...
(Date:7/24/2014)... , July 24, 2014  Asterias Biotherapeutics, Inc. ... emerging field of regenerative medicine, announced today that ... presentation to investors on Tuesday, July 29, 2014, ... presentation will include an overview of Asterias, business ... webcast, visit http://www.ustream.tv/channel/asterias-biotherapeutics at least 15 ...
Breaking Biology Technology:Monitoring the rise and fall of the microbiome 2Monitoring the rise and fall of the microbiome 3Pittcon 2015 Announces Call for Topics for Conferee Networking Sessions 2Sinovac to Host Conference Call to Report Second Quarter 2014 Unaudited Financial Results 2Asterias Biotherapeutics Announces Live Investor Webcast 2Asterias Biotherapeutics Announces Live Investor Webcast 3Asterias Biotherapeutics Announces Live Investor Webcast 4
... S.C., April 23 Signalife, Inc.,(Amex: SGN ... and Trademark,Office has awarded the Company a new ... Monitoring Heartbeats Of A Patient". The patent, which,covers ... develop new,proprietary products., Patent attorneys from Fulwider ...
... Novel Nucleoside Analogue; New ... CEO and Directors Appointed, ... announced today that on April 18, 2008 it acquired,Virium Pharmaceuticals ... with a portfolio of,clinical stage product candidates focused in oncology, ...
... Champions,Biotechnology, Inc. (OTC Bulletin Board: CSBR), a company ... tumor specific data to,enhance the value of oncology ... financing. Under the terms of the private investment,Champions ... stock at $1.75 per share. There were no ...
Cached Biology Technology:Signalife Awarded New U.S. Patent, 'System For, And Method Of, Monitoring Heartbeats Of A Patient' 2MacroChem Acquires Virium Pharmaceuticals 2MacroChem Acquires Virium Pharmaceuticals 3MacroChem Acquires Virium Pharmaceuticals 4MacroChem Acquires Virium Pharmaceuticals 5Champions Biotechnology, Inc. Completes $2,500,000 Private Financing at $1.75 per Share 2Champions Biotechnology, Inc. Completes $2,500,000 Private Financing at $1.75 per Share 3
Water Distilled (Gibco™) is membrane filtered and endotoxin screened....
Immunogen: Human Respiratory Syncytial Virus (RSV) and Bovine Respiratory Syncytial Virus (BRSV) Fusion protein Storage: -20 C, Avoid Freeze/Thaw Cycles...
Mus musculus MARCKS-like protein, mRNA...
... HandyStep electronic from BRAND adds ergonomics ... is the only electronic, motor-driven repeating ... tips, including BRAND PD-Tip syringe tips, ... Dispenser Tips,and VWRbrand Combi-Syringes. Select virtually ...
Biology Products: