Navigation Links
Self-organized pituitary-like tissue from mouse ES cells
Date:11/14/2011

November 14, 2011 The possibility that functional, three-dimensional tissues and organs may be derived from pluripotent cells, such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), represents one of the grand challenges of stem cell research, but is also one of the fundamental goals of the emerging field of regenerative medicine. Developmental biology has played a central role in informing such efforts, as it has been shown that stem cell differentiation can be directed to follow a given lineage pathway by culturing stem cells in conditions that recapitulate the specific cellular and molecular environment from which such cells normally emerge during embryogenesis. Intriguingly, recent work has shown that when ES cells are cultured under the appropriate conditions, they can be driven to self-organize into complex, three-dimensional tissue-like structures that closely resemble their physiological counterparts, a remarkable advance for the field.

New work by Hidetaka Suga of the Division of Human Stem Cell Technology, Yoshiki Sasai, Group Director of the Laboratory for Organogenesis and Neurogenesis, and others has unlocked the most recent achievement in self-organized tissue differentiation, steering mouse ESCs to give rise to tissue closely resembling the hormone-secreting component of the pituitary, known as the adenohypophysis, in vitro. Conducted in collaboration with Yutaka Oiso at the Nagoya University Graduate School of Medicine, this work was published in Nature.

The Sasai group has complied an impressive list of achievements in induced differentiation using an ES cell culture technique dubbed SFEBq (shorthand for "serum-free floating culture of embryoid body-like aggregates with quick re-aggregation"), including high-efficiency methods for the differentiation of dopaminergic, cerebral cortex, cerebellar Purkinje, and other neuronal cell types. In recent years, refinements of this approach have enable
'/>"/>

Contact: Douglas Sipp
sipp@cdb.riken.jp
RIKEN
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Tufts University researcher develops living tissue
2. Manufacturing microscale medical devices for faster tissue engineering
3. New composite material may restore damaged soft tissue
4. Study shows answers for treating obesity-related diseases may reside in fat tissue
5. More than bacon: Genetic alterations in pig tissue may allow for human transplantation
6. IADR/AADR publish proceedings from Symposium on Tissue Injury and Pulp Regeneration
7. Progress in tissue engineering to repair joint damage in osteoarthritis
8. Yale scientists discover new method for engineering human tissue regeneration
9. Extracting stem cells from fat for tissue regeneration
10. Repulsion more important than cohesion in embryonic tissue separation
11. Molecular muscle: Small parts of a big protein play key roles in building tissues
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2014)... --  News Highlights: , ... Partners Data Lake, an agile data and analytics ... allow researcher and clinicians to explore and develop ... of patients , The Partners Data Lake ... Partners system, breaking down physical barriers for collaboration ...
(Date:11/18/2014)... NEW YORK , Nov. 18, 2014 /PRNewswire/ ... iris-based identity authentication solutions, and MorphoTrust USA ... solutions and services, today announced a strategic partnership ... across enterprise, motor vehicle administration (MVA), airport screening ... leader in identity-related solutions, MorphoTrust serves consumers through ...
(Date:11/12/2014)... GARDENS, Fla. , Nov. 12, 2014 ... announced today that its U.are.U ® fingerprint readers ... bakery chain in Central Mexico . ... June 2014 to eliminate payroll issues caused by employees ... to installing the U.are.U fingerprint readers, Montparnasse relied on ...
Breaking Biology News(10 mins):Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2
... ocean where an essential nutrientironis scarce, a marine bacterium that ... biochemical trick: It recycles iron. By day, it uses ... night, it appears to reuse the same iron in different ... Crocosphaera watsonii , is one of the few marine ...
... Rochelle, NY, January 10, 2011The mega-mergers of 2009 did not ... each had a price tag of more than $40 billion, ... to an evaluation of reported deals conducted by Genetic Engineering ... mega takeover for the year, sanofi-aventis, move to buy Genzyme, ...
... CHAMPAIGN, Ill. Using detailed land analysis, Illinois ... land could produce up to half of the world,s ... pastureland. Published in the journal Environmental Science ... environmental engineering professor Ximing Cai identified land around the ...
Cached Biology News:'Hot-bunking' bacterium recycles iron to boost ocean metabolism 2'Hot-bunking' bacterium recycles iron to boost ocean metabolism 3GEN reports on biotech acquisition deals in 2010 that topped $1 billion 2Study estimates land available for biofuel crops 2
(Date:12/17/2014)... (PRWEB) December 17, 2014 Gene ... that it has entered into a technology access ... (ADM) to apply DNA2.0’s proprietary protein engineering technology, ... process. , “We are extremely excited that the ... platform. This proprietary bioengineering technology has now ...
(Date:12/17/2014)... SOUTH SAN FRANCISCO, Calif. , Dec. 17, ... positive results of a Phase 2 study evaluating ... for the treatment of patients with severe, chronic ... the current standard of care, including topical steroids ... endpoint was percent change in Visual Analog Scale ...
(Date:12/15/2014)...  GlassesOff Inc. (OTCBB: GLSO) announced today the appointment ... director of the Company,s Board of Directors. ... its CEO until its acquisition by Stanley Black ... Recognized as the inventor of the first Wi-Fi-based Active ... -based RFID solutions focused on improving operational efficiency, safety ...
(Date:12/13/2014)... (PRWEB) December 12, 2014 Clarassance, a ... announced its new name: Therabron Therapeutics , Inc. ... and bronchioles (a type of structure in the lungs ... company’s mission to develop novel protein therapeutics for the ... directors decided to change the name to mark the ...
Breaking Biology Technology:ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3Maryland-based Biotech Company's Path Forward in Treating Respiratory Diseases Sparks Name Change 2
... Chilcott,Limited (Nasdaq: WCRX ) announced today that it ... the market opening on Friday,November 9, 2007. The ... audio webcast,on Friday, November 9, 2007 at 8:00 AM ... call, please dial (888) 503-8171 in the,United States and ...
... The Cervical Spine Now Available In ... ... Trinity,Clinic Neurosurgeon and Director of the Trinity Mother Frances Neuroscience,Institute is the ... that can provide some patients a chance to maintain,motion in their necks ...
... System delivers unmatched out-of-the-box functionality, BENSALEM, ... (Stelex), the market leader in providing enterprise-wide,compliance ... the,Quality Management System (QMS) module for Livelink ... provider of Enterprise Content,Management (ECM) software and ...
Cached Biology Technology:Video: Trinity Mother Frances Neurosurgeon Using New Disc System for Patients With Degenerative Diseases of the Neck 2Stelex Announce QMS Module for Open Text's Livelink ECM 2Stelex Announce QMS Module for Open Text's Livelink ECM 3
... Gene Pulser Xcell eukaryotic system, ... Hz, is used for electroporation ... includes the main unit, CE ... range) or square-wave pulses, ShockPod ...
Request Info...
... 96 and PowerPac basic power supply are used ... in agarose gels. This Model 96 cell includes ... UV-transparent gel tray with fluorescent ruler, and a ... and 220-240 V, provides output of 10-300 V, ...
... This CE-based system provides clear advantages ... (viral load, gene expression), mutation analysis, ... easy-to-use system with microplate connectivity is ... and quality control. The P/ACE ...
Biology Products: