Navigation Links
Self-help -- tumors promote their own metastasis
Date:4/30/2010

Louisville, KY Current research suggests that tumor-secreted exosomes inhibit the immune response, enhancing tumor metastasis. The related report by Liu et al, "Contribution of MyD88 to the tumor exosome-mediated induction of myeloid derived suppressor cells," appears in the May 2010 issue of The American Journal of Pathology.

The immune system plays a critical role in identifying and destroying tumor cells. Many tumors overcome this surveillance by inhibiting local immune responses, often leading to metastasis.

One potential method of tumor-mediated immune suppression is secretion of exosomes - small, membrane-enclosed sacs that can be used for storage or transport. Researchers led by Dr. Huang-Ge Zhang and colleagues at the University of Alabama at Birmingham and the University of Louisville, KY therefore examined the effect of tumor-secreted exosomes in lung metastasis. They found that treatment with tumor exosomes increased the number of myeloid-derived suppressor cells, which inhibited immune activation and accelerated tumor metastasis in the lung. This effect was mediated by the molecule MyD88, which plays a key role in the innate immune response.

In this study, Liu et al "identified the role of tumor exosomes in the enhancement of tumor metastasis through the expansion of myeloid-derived suppressor cells. A tremendous amount of information remains to be discovered about the mechanisms of cellular machinery that regulates the sorting of immune suppressor molecules into tumor exosomes. [Their] goal will now be to develop not only strategies to interfere with these pathways, but to transform tumor exosomes from immune suppressors to immune stimuli with the objective to ultimately use these modified exosomes as a tumor vaccine."


'/>"/>

Contact: Angela Colmone, Ph.D.
acolmone@asip.org
301-634-7953
American Journal of Pathology
Source:Eurekalert

Page: 1

Related biology news :

1. Invasion of the brain tumors
2. Analysis of breast and colon cancer genes finds many areas of differences between tumors
3. Cell response to stress signals predicts tumors in women with common pre-breast cancer
4. Synthetic compound promotes death of lung-cancer cells, tumors
5. MIT: Remote-control nanoparticles deliver drugs directly into tumors
6. New X-ray technique targets terrorists and tumors
7. DNA methylation shown to promote development of colon tumors
8. Genetic breakthrough offers promise in tackling kidney tumors
9. Tumor-targeting viral therapy slows neuroblastoma, malignant peripheral nerve sheath tumors
10. Veterinary college researcher studying brain tumors in people and animals
11. Needle-size device created to track tumors, radiation dose
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... Yale School of Medicine have pinpointed a mechanism in part ... in the blood, linking it to both type 1 and ... 28 issue of Proceedings of the National Academies of ... enzyme located in a part of the hypothalamus known ... in motion that control glucose levels in the blood," said ...
(Date:7/28/2014)... other forms of dementia, but the research community is ... Washington bioengineers have a designed a peptide structure that ... proteins into a state that,s linked to widespread diseases ... and Lou Gehrig,s disease. The synthetic molecule blocks these ... an abnormally folded form by targeting a toxic intermediate ...
(Date:7/28/2014)... Hospital study found that 73 percent of adult survivors ... developing metabolic syndrome and related health problems by failing ... the current issue of the journal Cancer . ... of childhood cancer in the study had metabolic syndrome, ... blood pressure, abdominal obesity, elevated triglyceride and other abnormalities ...
Breaking Biology News(10 mins):Glucose 'control switch' in the brain key to both types of diabetes 2New protein structure could help treat Alzheimer's, related diseases 2New protein structure could help treat Alzheimer's, related diseases 3Unhealthy habits more than double risk of metabolic syndrome in childhood cancer survivors 2Unhealthy habits more than double risk of metabolic syndrome in childhood cancer survivors 3
... their ongoing studies of how yeast (fungi) can infect ... the Life Sciences and Bioengineering Center at Worcester Polytechnic ... that yeast produce a hormone previously known to be ... hormone in sufficient quantity within the yeast,s immediate environment ...
... the University of Illinois have developed a new, more ... emissions that results from changes in land use. ... Change Biology , takes into account many factors not ... There is an urgent need to accurately assess whether ...
... CHAPEL HILL When the arteries delivering oxygen to our ... is almost always a stroke, heart attack or damage to ... But the severity of tissue injury or destruction from ... may depend in large part on whose circulatory system has ...
Cached Biology News:Discovery: Yeast make plant hormone that speeds infection 2Researchers calculate the greenhouse gas value of ecosystems 2Researchers calculate the greenhouse gas value of ecosystems 3Study pinpoints new role of molecule in the health of body's back-up blood circulation 2Study pinpoints new role of molecule in the health of body's back-up blood circulation 3Study pinpoints new role of molecule in the health of body's back-up blood circulation 4
(Date:7/28/2014)... (PRWEB) July 28, 2014 According ... Transparency Market Research "Regenerative Medicine (Bone and Joint) ... and Tissue Engineering; By Applications - Bone Graft ... Others) - Global Industry Analysis, Size, Share, Growth, ... regenerative medicine (bone and joint) market was valued ...
(Date:7/28/2014)... , July 28, 2014  David Hardison, ... ConvergeHEALTH by Deloitte , has been elected chairman ... Standards Consortium, a non-profit working to establish common ... particularly as it relates to electronic health records. ... CDISC,s mission of collaborating with organizations across the ...
(Date:7/28/2014)... July 28, 2014 The global market ... by 2020, according to a new study by Grand ... rising demand for effective vaccines and drugs in an ... medical needs is expected to drive market demand over ... enhance agricultural productivity via the use of genetically engineered ...
(Date:7/26/2014)... 26, 2014 Canada Endoscopy Visualization ... data on the Canada Endoscopy Visualization Systems market. ... dollars, volume (in units) and average prices (in ... Visualization Systems, Mid-Range Endoscopy Visualization Systems and Low-End ... http://www.marketresearchreports.biz/analysis/213254 . , The report also provides ...
Breaking Biology Technology:Regenerative Medicine Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 2Regenerative Medicine Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 3Regenerative Medicine Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 4ConvergeHEALTH by Deloitte's David Hardison Named Chairman of the Clinical Data Interchange Standards Consortium 2ConvergeHEALTH by Deloitte's David Hardison Named Chairman of the Clinical Data Interchange Standards Consortium 3Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 2Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 3Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 4Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 2Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 3Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 4Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 5
... LEXINGTON, Mass., Feb. 14, 2012 Avaxia Biologics, ... drugs that act locally within the gastrointestinal tract, ... million Series A angel-led financing.  Cherrystone Angels of ... from Beacon Angels, Boston Harbor Angels, Launchpad Venture ...
... a task force comprised of Indianapolis business, academic and ... Indiana,s life sciences sector that would catapult the state,s ... into a 21st-century hub for biotechnology and medical technology. ... state into the national spotlight as a leader and ...
... Calif., Feb. 13, 2012 Amgen (NASDAQ: AMGN ... 9:30 a.m. Eastern Standard Time  on Thursday, Feb. 16, 2012, ... M. Peacock, executive vice president and chief financial officer at ... presentation can be accessed from the Events Calendar on Amgen,s ...
Cached Biology Technology:Avaxia Biologics, Inc. Closes $4.1 Million Series A Financing to Advance Oral Antibodies for Inflammatory Bowel Disease 2Avaxia Biologics, Inc. Closes $4.1 Million Series A Financing to Advance Oral Antibodies for Inflammatory Bowel Disease 3BioCrossroads Commemorates Decade of Collaboration, Success for Indiana Life Sciences Sector 2BioCrossroads Commemorates Decade of Collaboration, Success for Indiana Life Sciences Sector 3
... on the ease of use and flexibility of the ... introduces the BDTM LSR II. The BD LSR ... in a benchtop analyzer. Free up your high-performance ... UV laser to the BD LSR II. The BD ...
... real-time PCR detection system uses a fixed ... nm) and two photomultiplier tubes for 2-color ... 2 system is built on an DNA ... gradient feature. This item includes the thermal ...
Fingerprinting II Basic software is used for analyzing fingerprint sample types (electrophoretic gels, HPLC and other chromatographic patterns, spectrophotometric and densitometric curves)....
Fingerprinting II database sharing tools is an optional module for the Fingerprinting II Basic software package that enables peer-to-peer data exchange over the internet and provides external databas...
Biology Products: