Navigation Links
Self-help -- tumors promote their own metastasis
Date:4/30/2010

Louisville, KY Current research suggests that tumor-secreted exosomes inhibit the immune response, enhancing tumor metastasis. The related report by Liu et al, "Contribution of MyD88 to the tumor exosome-mediated induction of myeloid derived suppressor cells," appears in the May 2010 issue of The American Journal of Pathology.

The immune system plays a critical role in identifying and destroying tumor cells. Many tumors overcome this surveillance by inhibiting local immune responses, often leading to metastasis.

One potential method of tumor-mediated immune suppression is secretion of exosomes - small, membrane-enclosed sacs that can be used for storage or transport. Researchers led by Dr. Huang-Ge Zhang and colleagues at the University of Alabama at Birmingham and the University of Louisville, KY therefore examined the effect of tumor-secreted exosomes in lung metastasis. They found that treatment with tumor exosomes increased the number of myeloid-derived suppressor cells, which inhibited immune activation and accelerated tumor metastasis in the lung. This effect was mediated by the molecule MyD88, which plays a key role in the innate immune response.

In this study, Liu et al "identified the role of tumor exosomes in the enhancement of tumor metastasis through the expansion of myeloid-derived suppressor cells. A tremendous amount of information remains to be discovered about the mechanisms of cellular machinery that regulates the sorting of immune suppressor molecules into tumor exosomes. [Their] goal will now be to develop not only strategies to interfere with these pathways, but to transform tumor exosomes from immune suppressors to immune stimuli with the objective to ultimately use these modified exosomes as a tumor vaccine."


'/>"/>

Contact: Angela Colmone, Ph.D.
acolmone@asip.org
301-634-7953
American Journal of Pathology
Source:Eurekalert

Page: 1

Related biology news :

1. Invasion of the brain tumors
2. Analysis of breast and colon cancer genes finds many areas of differences between tumors
3. Cell response to stress signals predicts tumors in women with common pre-breast cancer
4. Synthetic compound promotes death of lung-cancer cells, tumors
5. MIT: Remote-control nanoparticles deliver drugs directly into tumors
6. New X-ray technique targets terrorists and tumors
7. DNA methylation shown to promote development of colon tumors
8. Genetic breakthrough offers promise in tackling kidney tumors
9. Tumor-targeting viral therapy slows neuroblastoma, malignant peripheral nerve sheath tumors
10. Veterinary college researcher studying brain tumors in people and animals
11. Needle-size device created to track tumors, radiation dose
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2016)... Jan. 22, 2016 ... of the "Global Biometrics Market in ... offering. --> http://www.researchandmarkets.com/research/p74whf/global_biometrics ) ... "Global Biometrics Market in Retail Sector 2016-2020" ... --> Research and Markets ( http://www.researchandmarkets.com/research/p74whf/global_biometrics ...
(Date:1/20/2016)... A market that just keeps on growing. ... explosion in genomics knowledge. Learn all about it in ... of dynamic trends are pushing market growth and company ... pharmacogenomics - pathogen evolution - next generation sequencing - ... understanding of the role of genetic material in Disease ...
(Date:1/20/2016)... Calif. , Jan. 20, 2016  Synaptics ... of human interface solutions, today announced sampling of ... solution for wearables and small screen applications including ... as printers. Supporting round and rectangular shapes, as ... offers excellent performance with moisture on screen, while ...
Breaking Biology News(10 mins):
(Date:2/5/2016)... , Feb. 5, 2016  In the pharmaceutical ... for a host of launch activities including the identification ... this launch activity is especially high in the oncology ... Best Practices and the Role of Medical Affairs ... companies focused on oncology therapies find better ways to ...
(Date:2/5/2016)... , February 5, 2016 Amarantus ... biotechnology company focused on developing products for Regenerative Medicine, ... Rare Pediatric Disease Designation (RPDD) from the US Food ... with MANF. MANF was previously granted orphan drug designation ... --> Amarantus BioScience Holdings, Inc. (OTCQB: ...
(Date:2/4/2016)... ... February 04, 2016 , ... Morf Media Inc ... an interactive FDA compliance training course, Writing Effective SOPs ... accredited interactive course on Morf Playbook—now conveniently available on smartphones and PCs--provides step ...
(Date:2/4/2016)... 2016  Sangamo BioSciences, Inc. (NASDAQ: SGMO ), ... Edward Lanphier , Sangamo,s president and chief executive ... Sangamo,s ZFP Therapeutic ® development programs and an ... ET on Thursday, February 11, 2016, at the Leerink ... conference is being held in New York ...
Breaking Biology Technology: