Navigation Links
Self-digestion as a means of survival
Date:2/27/2009

oats around in the cytoplasm. Not unlike white blood cells, they can engulf larger proteins or even whole cell organelles. But since they have no enzymes with which they can digest their own cargo, they fuse with lysosomes. When a Yoshinori Ohsumi's group in Japan reported that they had discovered ubiquitin-like proteins (ATG8) on the outer surface of the autophagosome and gone on to prove that they were specific for autophagy, Dikic and his colleague Dr. Vladimir Kirkin immediately began their search for potential autophagy receptors that might bind to the family of ATG8 proteins.

The team of international scientists report in the current issue of the renowned journal "Molecular Cell", that by employing methods from cell biology, biochemistry and mouse genetics, they have been able to identify a further protein, in addition to the known p62/SQSTM1 protein, that may act as a receptor. This is the protein NBR1, which has long been associated with cancer. Both proteins have a similar chain-like structure. At one end they bind to the ubiquitin that marks the protein aggregates and organelles that are to be degraded. Next to the ubiquitin-binding site is a domain that binds to the ATG8 proteins found at the autophagosomal membrane. Here, the protein waste can dock onto the autophagosome and can then be wrapped up in the membrane.

Vladimir Kirkin, who is now at Merck Serono in Darmstadt, is continuing these investigations with the long-term aim of developing new drugs. Dikic and his group are now concentrating on mitochondria - which are implicated in oxidative stress in cells - hoping to locate the receptors for autophagy on these important organelles.


'/>"/>

Contact: Ivan Dikic
ivan.dikic@biochem2.de
49-696-301-83647
Goethe University Frankfurt
Source:Eurekalert

Page: 1 2

Related biology news :

1. Shorter wait means longer life for kidney transplant candidates
2. Researchers devise means to create blood by identifying earliest stem cells
3. Scientists demonstrate means of reducing Alzheimers-like plaques in fly brain
4. Bad news for coastal ocean: less fish out, means more nitrogen in
5. Less Arctic ice means higher risks, experts warn
6. Dana-Farber oncologists present at ASCO GU -- predict prostate cancer survival using Source MDx test
7. Malaria parasite zeroes in on molecule to enhance its survival, team finds
8. Genetic adaptations key to microbes survival in challenging environment
9. From seed to nuts: human ancestors face evolved to eat survival foods
10. Survival in a Changing World: The Journal of Experimental Biology 2009 symposium
11. Shared survival mechanism explains why good nerve cells last and bad cancer cells flourish
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/15/2015)... , June 16, 2015 ... Processing Market by Type (Rule-Based, Statistical, and Hybrid), Technologies ... Forecast to 2020" published by MarketsandMarkets, The Natural Language ... at a CAGR of 18.4% for the forecast period ... and   46 F igures spread   through ...
(Date:6/15/2015)... 15, 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... growing mobile commerce market, announces that its leading payment security ... at Digital Experience! @ NYC June 18th. Digital ... latest innovation in technology to over 300 of the top ... the Metropolitan Pavilion in New York City ...
(Date:6/11/2015)... RESTON, Va. , June 11, 2015 /PRNewswire/ ... authentication technology, announced today that its IdentityX Mobile ... FIDO (Fast IDentity Online) Alliance is an industry ... with open standards for simpler, stronger authentication.  In ... services must pass a rigorous series of tests ...
Breaking Biology News(10 mins):Natural Language Processing Market Worth $13.4 Billion by 2020 2Natural Language Processing Market Worth $13.4 Billion by 2020 3Natural Language Processing Market Worth $13.4 Billion by 2020 4Natural Language Processing Market Worth $13.4 Billion by 2020 5Wocket Smart Wallet Exhibiting at Pepcom Digital Experience! @ NYC June 18th 2Wocket Smart Wallet Exhibiting at Pepcom Digital Experience! @ NYC June 18th 3Daon's IdentityX Mobile Authentication Platform One of First Products to be Certified by FIDO Alliance 2
... Vito Quaranta clicks on a small black dot on ... thousand cancer cells ?begins to "grow," morphing into a ... tumor. , The Vanderbilt professor of cancer biology envisions ... used to predict a tumor's clinical progression and formulate ...
... and how some plant seeds store iron, a valuable discovery ... Their research helps address the worldwide problem of iron deficiency ... is stored in the developing vascular system of the seed ... iron is stored in the vacuole, a plant cell's central ...
... treats a type of lymphoma associated with chlamydia infection, according ... Journal of the National Cancer Institute. ... kind of cancer of the eyelids and related tissues. It ... patient's quality of life. Some research has suggested an association ...
Cached Biology News:Math model predicts cancer behavior 2Math model predicts cancer behavior 3Math model predicts cancer behavior 4Plant studies reveal how, where seeds store iron 2
(Date:7/6/2015)... BARBARA, Calif. , July 6, 2015  Approximately ... that is integrated into their chromosomes. These individuals are ... a new study published in one of the nation,s ... Faculty of Medicine in Canada.  Photo - ... as human herpesvirus 6 (HHV-6) causes roseola (also known ...
(Date:7/6/2015)... , July 6, 2015  Viveve Medical, Inc. ("Viveve") (OTCQB: VIVMF), ... Patricia Scheller , Viveve,s Chief Executive Officer, and Scott ... VirtualInvestorConferences.com on July 9, 2015. , , , ... , , , TIME:     , , , ... , , , http://tinyurl.com/viveve   , ...
(Date:7/3/2015)... Texas (PRWEB) , ... July ... ... biotechnology company providing industry-leading products for use in applications such as animal ... in wastewater treatment plants and restaurant kitchen settings, announced today that it ...
(Date:7/3/2015)... July 3, 2015 ... september 2015 på  http://www.openinnovationinscience.at till det ... Science" som hålls i Wien ... undersökning med internationella forskare och vetenskapsmän som ... hälsovetenskapens två största utmaningar bristen på incitament ...
Breaking Biology Technology:Inherited Herpes Virus Increases the Risk of Angina Reports HHV-6 Foundation 2Inherited Herpes Virus Increases the Risk of Angina Reports HHV-6 Foundation 3Viveve to Webcast Live at VirtualInvestorConferences.com 2Viveve to Webcast Live at VirtualInvestorConferences.com 3DryLet to Highlight Benefits of Patented ManureMagic™ at North American Manure Expo in Chambersburg, PA July 14-15, 2015 2Lansering av världens första program för öppen innovation för att utbilda forskare 2Lansering av världens första program för öppen innovation för att utbilda forskare 3
... showcase Wis. startups, biotech , ,Entrepreneurship, nanotechnology and ... June 1-4 in Madison and Milwaukee, giving substance to ... Research Week. , , Tips for Entrepreneurs , ... Wisconsin Entrepreneurs Conference , which runs June 1-2 ...
... focusing on the past, present and future of DOC policy and initiatives ... in March 2004. , , Part 2 ... the past year, what accomplishments are you most proud of, in spite ... new position? , , Cory Nettles: I think what Gov. ...
... and open-source software vied for the support of an ... the ITEC conference in Milwaukee. , ,Marc Rassbach, principle ... software provides a technically superior system, but Windows has ... obvious place to turn for direction. Nevertheless, he advocated ...
Cached Biology Technology:Doyles Entrepreneurs and Research week nears 2Doyles Entrepreneurs and Research week nears 3WTN exclusive interview with Commerce Secretary Cory Nettles (part 1) 2WTN exclusive interview with Commerce Secretary Cory Nettles (part 1) 3WTN exclusive interview with Commerce Secretary Cory Nettles (part 1) 4WTN exclusive interview with Commerce Secretary Cory Nettles (part 1) 5Linux and Windows duke it out at ITEC 2Linux and Windows duke it out at ITEC 3
... and miRNA Isolation Traditional mRNA isolation ... and can result in the loss of ... miRNA Isolation Kit purifies all RNA species ... Through an enrichment procedure included in the ...
anti-JNK2 Immunogen: Recombinant human JNK2 protein Accession Number: NM_002752 Quality Assurance: Routinely evaluated by immunoblot. Molecular Weight: 46 and/or 54 kDa Available ...
... ZMD.330. Immunogen: Synthetic peptide derived from ... and mouse protein kinase C zeta isoform ... and mouse PKCzeta protein. Recognizes PKCzeta ... cross-react with PKCiota/lambda. Reactivity: Mouse Rat ...
Lipid-rich bovine serum albumin for cell culture. It is chromatographically purified and has an IgG content 1.0% (w/w)....
Biology Products: