Navigation Links
Self-assembling nano-fiber gel delivers high concentrations of clinically approved drugs
Date:10/21/2008

BOSTON, Mass. (Oct. 20, 2008) -- Two teams of scientists from Harvard-MIT Division of Health Science and Technology (HST) at Brigham and Women's Hospital have developed a new self-assembling hydrogel drug delivery system that is biocompatible, efficient at drug release, and easy to tailor. Importantly, these structures can deliver clinically approved drugs in high concentrations without requiring carriers for the drug or generating toxic components, a problem with hydrogel systems until now.

The findings, which are now available on Science Direct, will be published in the Nov. 25 issue of Biomaterials.

"This strategy could serve as the platform technology for developing drug-based delivery carriers that can release drugs such as anti-inflammatory agents on demand in response to inflammation, for example," says Jeffrey Karp, MD, instructor of medicine at the HST Center for Biomedical Engineering at the Brigham and Women's Hospital and a co-corresponding author on this manuscript.

"Converting known, clinically-practicing drugs into amphiphilic molecules which can undergo self-assembly is the key development in our present research; this may eliminate the need for an external carrier for delivering drugs" says Praveen Kumar Vemula, PhD, research fellow in medicine at Brigham and Women's Hospital.

"Enzyme triggered gel degradation has been our key strength, which played a major role in developing these delivery vehicles from drugs-based hydrogels" says another leading investigator Dr. George John, who is associate professor at City College of New York. Gregory Cruikshank, another author of the article is at present working in Albert Einstein College of Medicine of Yeshiva University.


'/>"/>

Contact: Laurie Pass
lpass@mit.edu
617-253-9457
Harvard Medical School
Source:Eurekalert

Page: 1

Related biology news :

1. New Sony PC Delivers High Performance in Ultra-Portable Package
2. Software developed by Boston College lab delivers speed and accuracy to genome research
3. Insecticide combo delivers knockout punch
4. e-Smart(R) Technologies Delivers Its New Super Smart Card(TM) in South Korea.
5. DOE JGI Community Sequencing Program delivers first moss genome
6. Lupus Research Institute strategy delivers $30 million in national funding
7. Mountain pine beetle: Canadas new government delivers
8. Pesticide concentrations decreasing
9. Nitrate concentrations of ground water increasing in many areas of the United States
10. Scientists develop a fast system to detect metal concentrations in iron and steel industry workers
11. International team shows mercury concentrations in fish respond quickly to increased deposition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/4/2017)... April 4, 2017   EyeLock LLC , a ... the United States Patent and Trademark Office (USPTO) has ... the linking of an iris image with a face ... represents the company,s 45 th issued patent. ... very timely given the multi-modal biometric capabilities that have ...
(Date:3/30/2017)... 2017 Trends, opportunities and forecast in this ... technology (fingerprint, AFIS, iris recognition, facial recognition, hand geometry, ... end use industry (government and law enforcement, commercial and ... and others), and by region ( North America ... Asia Pacific , and the Rest of the ...
(Date:3/24/2017)... March 24, 2017 The Controller General of Immigration ... Abdulla Algeen have received the prestigious international IAIR Award for ... Continue Reading ... ... Deputy Controller Abdulla Algeen (small picture on the right) have received the ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... Tampa Bay, Florida (PRWEB) , ... October 11, ... ... Food and Drug Administration (FDA) has granted orphan drug designation to SBT-100, its ... antibody (sdAb) for the treatment of osteosarcoma. SBT-100 is able to cross the ...
(Date:10/10/2017)... DALLAS , Oct. 10, 2017 International research firm ... IoT Strategy, will speak at the TMA 2017 Annual Meeting , ... key trends in the residential home security market and how smart safety ... ... "The ...
(Date:10/9/2017)... ... 09, 2017 , ... The award-winning American Farmer television series will feature 3 ... airs Tuesdays at 8:30aET on RFD-TV. , With global population estimates nearing ten ... to continue to feed a growing nation. At the same time, many of our ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... ProxiMeta™ Hi-C metagenome deconvolution product, featuring the first commercially available Hi-C kit. ... to perform Hi-C metagenome deconvolution using their own facilities, supplementing the company’s ...
Breaking Biology Technology: