Navigation Links
Selectively manipulating protein modifications
Date:3/10/2013

This press release is available in German.

Protein activity is strictly regulated. Incorrect or poor protein regulation can lead to uncontrolled growth and thus cancer or chronic inflammation. Members of the Institute of Veterinary Biochemistry and Molecular Biology from the University of Zurich have identified enzymes that can regulate the activity of medically important proteins. Their discovery enables these proteins to be manipulated very selectively, opening up new treatment methods for inflammations and cancer.

For a healthy organism, it is crucial for proteins to be active or inactive at the right time. The corresponding regulation is often based on a chemical modification of the protein structure: Enzymes attach small molecules to particular sites on a protein or remove them, thereby activating or deactivating the protein. Members of the Institute of Veterinary Biochemistry and Molecular Biology from the University of Zurich in collaboration with other Institutes have now discovered how the inactivation of a protein, which is important for medicine, can be reversed.

New group of ADP-ribosylhydrolases identified

An important protein modification is ADP-ribosylation, which is involved in certain types of breast cancer, cellular stress reactions and gene regulation. So-called ADP-ribosyltransferases attach the ADP ribose molecule to proteins, thereby altering their function. In recent years, many ADP-ribosyltransferases have been discovered that can convey single or several ADP-riboses to different proteins. Enzymes that can remove these riboses again, however, are less well known. Professor Michael Hottiger's team of researchers has now identified a new group of such ADP-ribosylhydrolases. The scientists discovered that a so-called macrodomain is responsible for removing the ADP-riboses in human proteins, but also in the bac
'/>"/>

Contact: Michael Hottiger
hottiger@vetbio.uzh.ch
41-446-355-474
University of Zurich
Source:Eurekalert

Page: 1 2

Related biology news :

1. Research breakthrough selectively represses the immune system
2. Experimental drug combination selectively destroys lymphoma cells
3. Manipulating chromatin loops to regulate genes may offer future treatments for blood diseases
4. Manipulating the microbiome could help manage weight
5. IU biologists offer clearer picture of how protein machine systems tweak gene expression
6. Making memories: How 1 protein does it
7. Embryonic development protein active in cancer growth
8. More effective method of imaging proteins
9. The loss of a protein makes jump the tumor to the lymph node
10. Gold nanoantennas detect proteins
11. The Japanese traditional therapy, honokiol, blocks key protein in inflammatory brain damage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/12/2015)... 2015  New research unveiled at Black Hat ... to steal users, fingerprints. Information released today by ... scanners on mobile devices, making the security of ... on mobile devices, HYPR Corp. recently released a ... systems with strong cryptographic security. More information on ...
(Date:8/10/2015)... and TELTOW, Germany , August ... (SMI), a world leader in Eye Tracking Technology ... of its OEM Eye Tracking Platform for integration into ... Platform contains reference designs for seamless integration of eye ... virtual reality HMDs and augmented reality smart glasses. Omnivision,s ...
(Date:8/6/2015)... Germany , August 6, 2015 /PRNewswire/ ... SensoMotoric Instruments (SMI) shows the world,s first ... based on Epson,s Moverio BT-200 see-through head mounted display ... new solution, unprecedented quality and efficiency is brought to ... displays. For the first time, professionals and researchers can ...
Breaking Biology News(10 mins):HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 2HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 3SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 2SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 3SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 2SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 3
... University of Adelaide geneticist Dr Jozef Gecz and a ... major breakthrough in discovering the causes of intellectual disability. ... at the Womens and Childrens Hospital in Adelaide, has ... various mutations of a small part of the X ...
... print edition of The FASEB Journal ( www.fasebj.org ) describes ... the availability of a wide range of drugs. In the ... therapy to reduce the time it takes to breed large ... as insulin or those that fight cancer. This represents a ...
... Harbor, NY Cold Spring Harbor Laboratory (CSHL) will ... called the iPlant Collaborative, funded by the National Science ... challenge questions in plant biology that have global implications. ... computer- and internet-based infrastructure that will transform the way ...
Cached Biology News:Scientists achieve major genetics breakthrough 2Pharmaceutical breakthrough may make a range of drugs cheaper and more available 2Cold Spring Harbor Laboratory to play central role addressing key questions in plant biology 2Cold Spring Harbor Laboratory to play central role addressing key questions in plant biology 3
(Date:8/27/2015)... VA (PRWEB) , ... August 27, 2015 , ... ... contractors solve complex business problems, is pleased to announce their ranking as one of ... annual ranking of the fastest-growing private companies across the nation. , “It is truly ...
(Date:8/27/2015)... 27, 2015 The National Necrotizing Fasciitis ... life—were saved by doctors at Vanderbilt University Hospital in ... NovaBay Pharmaceuticals and Dr. John Crew , director ... Seton Medical Center in Daly City, CA. ... breakthrough approach, pioneered by Dr. Crew, that had previously ...
(Date:8/27/2015)... SAN DIEGO , Aug. 27, 2015 ... second annual meeting of the Japan Society of HTLV-1, ... Science Institute Auditorium. The purpose of the Society is ... well as the development of medical technology and research ... health and welfare. "HUYA is proud to ...
(Date:8/27/2015)... ... August 27, 2015 , ... METTLER TOLEDO's web-based ... the product choices to a manageable shortlist of bench and floor scales and ... that fit best with the customer’s industry and application. , Side-by-side product ...
Breaking Biology Technology:Capital Edge Consulting Makes Inc. 5000 List of America’s Fastest-Growing Private Companies 2Capital Edge Consulting Makes Inc. 5000 List of America’s Fastest-Growing Private Companies 3Patient's Life and Eyes Saved from Gruesome Flesh-Eating Infection Consuming Her Face 2Patient's Life and Eyes Saved from Gruesome Flesh-Eating Infection Consuming Her Face 3HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 2HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 3HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 4METTLER TOLEDO Updates Online Scale Selection Tool 2
... HILL, N.C., Sept. 19, 2011 During this period ... function – principally internal and external communications – plays ... While they serve critical - albeit ... external communications groups are responsible for communicating corporate objectives ...
... and TORONTO, Sept. 19, 2011 Generex Biotechnology ... Antigen Express, Inc. ( www.antigenexpress.com ), today announced ... treatment of breast, prostate, and other cancers, is ... Expert Opinion on Biological Therapy , a peer-reviewed, ...
... 19, 2011 BioRestorative Therapies, Inc. (OTCQB: BRTX) (the "Company"), ... its common stock is now trading on the OTCQB market ... trading symbol for its common stock has been changed from ... and Chief Executive Officer, said, "The commencement of trading using ...
Cached Biology Technology:Creating a High-Performing Communications Group in Turbulent Times 2Antigen Express Cancer Vaccine Highlighted in Expert Opinion on Biological Therapy 2Antigen Express Cancer Vaccine Highlighted in Expert Opinion on Biological Therapy 3Antigen Express Cancer Vaccine Highlighted in Expert Opinion on Biological Therapy 4Antigen Express Cancer Vaccine Highlighted in Expert Opinion on Biological Therapy 5BioRestorative Therapies, Inc. Begins Trading Under New Name and Symbol ("BRTX") 2
... Hitachi Innovative Linear Ion Trap Time of Flight Mass Analyzer for ... mode measurement range: 100 - 25,000 m/z, * Precursor ion selection ... over, * MS accuracy: 5 ppm with internal reference, * Dynamic ... ...
Four siRNAs targeting your gene of interest, providing gene silencing with 100% satisfaction guaranteed High knockdown potency , High specificity for minimal off-target effects , Flexible siR...
Mouse polyclonal antibody to BTAF1 - BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae)...
... series combines Harvard Apparatuss best pump mechanism, a ... range of configuration options. A lookup table in ... from all the major manufacturers. A bright, two ... information from across the lab. All models have ...
Biology Products: