Navigation Links
Selectively manipulating protein modifications
Date:3/10/2013

This press release is available in German.

Protein activity is strictly regulated. Incorrect or poor protein regulation can lead to uncontrolled growth and thus cancer or chronic inflammation. Members of the Institute of Veterinary Biochemistry and Molecular Biology from the University of Zurich have identified enzymes that can regulate the activity of medically important proteins. Their discovery enables these proteins to be manipulated very selectively, opening up new treatment methods for inflammations and cancer.

For a healthy organism, it is crucial for proteins to be active or inactive at the right time. The corresponding regulation is often based on a chemical modification of the protein structure: Enzymes attach small molecules to particular sites on a protein or remove them, thereby activating or deactivating the protein. Members of the Institute of Veterinary Biochemistry and Molecular Biology from the University of Zurich in collaboration with other Institutes have now discovered how the inactivation of a protein, which is important for medicine, can be reversed.

New group of ADP-ribosylhydrolases identified

An important protein modification is ADP-ribosylation, which is involved in certain types of breast cancer, cellular stress reactions and gene regulation. So-called ADP-ribosyltransferases attach the ADP ribose molecule to proteins, thereby altering their function. In recent years, many ADP-ribosyltransferases have been discovered that can convey single or several ADP-riboses to different proteins. Enzymes that can remove these riboses again, however, are less well known. Professor Michael Hottiger's team of researchers has now identified a new group of such ADP-ribosylhydrolases. The scientists discovered that a so-called macrodomain is responsible for removing the ADP-riboses in human proteins, but also in the bacterium Archaeoglobus fulgidus.

"We therefore assume that the reversal of the modification takes place in a similar way in different species," explains Michael Hottiger.

Biomedically relevant: inactivation of the modified enzyme GSK3β

The researchers also prove that ADP-ribosylhydrolases can remove the ADP-ribose of the intensively studied enzyme GSK3β, which regulates the synthesis of storage substances and is important in the progression of various diseases. ADP-ribosylation deactivates GSK3β, which can be reversed again by the newly identified enzyme. "Our discovery enables ADP-ribose modification to be manipulated and tested selectively, and new treatment methods developed for diseases such as inflammations or cancer," concludes Michael Hottiger.


'/>"/>

Contact: Michael Hottiger
hottiger@vetbio.uzh.ch
41-446-355-474
University of Zurich
Source:Eurekalert

Related biology news :

1. Research breakthrough selectively represses the immune system
2. Experimental drug combination selectively destroys lymphoma cells
3. Manipulating chromatin loops to regulate genes may offer future treatments for blood diseases
4. Manipulating the microbiome could help manage weight
5. IU biologists offer clearer picture of how protein machine systems tweak gene expression
6. Making memories: How 1 protein does it
7. Embryonic development protein active in cancer growth
8. More effective method of imaging proteins
9. The loss of a protein makes jump the tumor to the lymph node
10. Gold nanoantennas detect proteins
11. The Japanese traditional therapy, honokiol, blocks key protein in inflammatory brain damage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... -- KEY FINDINGS The global market for ... of 25.76% during the forecast period of 2017-2025. The ... the growth of the stem cell market. ... INSIGHTS The global stem cell market is segmented on ... stem cell market of the product is segmented into ...
(Date:4/3/2017)... , April 3, 2017  Data ... precision engineering platform, detected a statistically significant ... product prior to treatment and objective response ... the potential to predict whether cancer patients ... to treatment, as well as to improve ...
(Date:3/30/2017)... -- The research team of The Hong Kong Polytechnic ... by adopting ground breaking 3D fingerprint minutiae recovery and matching technology, ... accuracy for use in identification, crime investigation, immigration control, security of ... ... A research team led by Dr ...
Breaking Biology News(10 mins):
(Date:9/21/2017)... ... September 21, 2017 , ... ... announced the election of Paul Hermes, Entrepreneur in Residence at Medtronic, Inc., to ... has developed a proprietary, tissue-engineered scaffold for anterior cruciate ligament (ACL) reconstruction that ...
(Date:9/20/2017)... ... 2017 , ... Diversity focused business accelerator, The Refinery , announced today ... uncover the top technology-driven, women-led startups in Boston, MA, New Haven/Hamden, CT, and Newark, ... events going on that week – in Boston, it will be part of the ...
(Date:9/20/2017)... N.J. (PRWEB) , ... September ... ... have recently published findings of a study examining the effects of exoskeleton-assisted ... with spinal cord injury (SCI). The article, "Neuromechanical adaptations during a robotic ...
(Date:9/20/2017)... ... September 20, 2017 , ... RoviSys, ... solutions, announced today the opening of an office in Taipei, Taiwan. This new ... China region, while developing new relationships in the region. Located in the Neihu ...
Breaking Biology Technology: