Navigation Links
Seizures linked to surgery drugs can be prevented by anesthetics, U of T team finds
Date:11/26/2012

Two drugs commonly given during cardiac surgery can lead to convulsive seizures, but anesthetics can help cut the risk, according to new research from the Faculty of Medicine at the University of Toronto.

Patients undergoing complex heart operations or trauma surgery are often given tranexamic acid (TXA) and aminocaproic acid (EACA) to reduce blood loss. But Faculty of Medicine researchers found these drugs are associated with a four-to-six-fold increase in post-operative seizures. The risk is highest for cardiac surgery patients between three and seven and a half per cent have seizures after arriving in the intensive care unit.

"Many Canadians are treated with these drugs, particularly TXA, each year to decrease bleeding and help patients avoid blood transfusions. Surgeons and anesthesiologists need to be mindful that these drugs can be pro-convulsants," says Beverley Orser, Professor of Physiology and Anesthesiology at the University of Toronto and Canada Research Chair.

"To decrease a patient's risk of seizure, it's critical to adjust the dose of TXA and EACA. In some cases where the risk of seizures is high, it is advisable to maintain a certain level of anesthetic sedation until the drugs wear off," says Orser, a staff anesthesiologist at Sunnybrook Health Sciences Centre.

Seizures can cause long-term, permanent neurological problems, increase the risk of stroke and prolong a patient's recovery time.

Clinicians had long been perplexed as to the cause of seizures associated with the use of TXA and EACA. Irene Lecker, a PhD candidate in Orser's laboratory, discovered that these drugs interfere with a naturally occurring anticonvulsant in the brain, glycine, and that widely used anesthetics reverse this interfering effect.

David Mazer, Professor and Vice-Chair of Research in the Department of Anesthesia at University of Toronto and co-investigator on the study, says this research will change the way these drugs are used around the world.

"Now that we understand what's happening inside the brain and the mechanism behind the seizures, we can treat patients better," he says.

Dr. Orser is using these findings, now published in Journal of Clinical Investigation, to work with the Sunnybrook Health Sciences Centre team to develop a new practice of drug administration during and after surgery.


'/>"/>

Contact: Nicole Bodnar
nicole.bodnar@utoronto.ca
416-978-5811
University of Toronto
Source:Eurekalert

Related biology news :

1. Early warning system for seizures could cut false alarms
2. Childhood virus infection linked to prolonged seizures with fever
3. Exposure to antibiotics linked to severity of allergic asthma: UBC research
4. Autism risk gene linked to differences in brain structure
5. Spontaneous gene glitches linked to autism risk with older dads
6. Dental X-rays linked to common brain tumor
7. Ocean acidification linked to larval oyster failure
8. First mass extinction linked to marine anoxia
9. Prenatal exposure to air pollution linked to childhood obesity
10. Knee injuries in women linked to motion, nervous system differences
11. Researchers discover first gene linked to missing spleen in newborns
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2016)... -- A new partnership announced today will help life ... a fraction of the time it takes today, ... insurance policies to consumers without requiring inconvenient and ... rapid testing (A1C, Cotinine and HIV) and higi,s ... pulse, BMI, and activity data) available at local ...
(Date:3/31/2016)...   LegacyXChange, Inc. ... LegacyXChange is excited to release its first ... be launched online site for trading 100% guaranteed authentic ... also provide potential shareholders a sense of the value ... industry that is notorious for fraud. The video is ...
(Date:3/22/2016)... PUNE, India , March 22, 2016 ... new market research report "Electronic Sensors Market for ... Fingerprint, Proximity, & Others), Application (Communication & ... and Geography - Global Forecast to 2022", ... consumer industry is expected to reach USD ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... ... medical technologies, services and solutions to the healthcare market. The company's primary focus ... distribution, manufacturing, sales and marketing strategies that are necessary to help companies efficiently ...
(Date:6/27/2016)... 27, 2016   Ginkgo Bioworks , a leading ... was today awarded as one of the World ... world,s most innovative companies. Ginkgo Bioworks is engineering ... real world in the nutrition, health and consumer ... with customers including Fortune 500 companies to design ...
(Date:6/24/2016)... NY (PRWEB) , ... June 24, 2016 , ... While ... machines such as the Cary 5000 and the 6000i models are higher end machines ... is the height of the spectrophotometer’s light beam from the bottom of the cuvette ...
(Date:6/23/2016)... Wausau, WI (PRWEB) , ... June 23, 2016 ... ... probiotic supplements, is pleased to announce the launch of their brand, UP4™ Probiotics, ... supplements for over 35 years, is proud to add Target to its list ...
Breaking Biology Technology: