Navigation Links
Seizures linked to surgery drugs can be prevented by anesthetics, U of T team finds
Date:11/26/2012

Two drugs commonly given during cardiac surgery can lead to convulsive seizures, but anesthetics can help cut the risk, according to new research from the Faculty of Medicine at the University of Toronto.

Patients undergoing complex heart operations or trauma surgery are often given tranexamic acid (TXA) and aminocaproic acid (EACA) to reduce blood loss. But Faculty of Medicine researchers found these drugs are associated with a four-to-six-fold increase in post-operative seizures. The risk is highest for cardiac surgery patients between three and seven and a half per cent have seizures after arriving in the intensive care unit.

"Many Canadians are treated with these drugs, particularly TXA, each year to decrease bleeding and help patients avoid blood transfusions. Surgeons and anesthesiologists need to be mindful that these drugs can be pro-convulsants," says Beverley Orser, Professor of Physiology and Anesthesiology at the University of Toronto and Canada Research Chair.

"To decrease a patient's risk of seizure, it's critical to adjust the dose of TXA and EACA. In some cases where the risk of seizures is high, it is advisable to maintain a certain level of anesthetic sedation until the drugs wear off," says Orser, a staff anesthesiologist at Sunnybrook Health Sciences Centre.

Seizures can cause long-term, permanent neurological problems, increase the risk of stroke and prolong a patient's recovery time.

Clinicians had long been perplexed as to the cause of seizures associated with the use of TXA and EACA. Irene Lecker, a PhD candidate in Orser's laboratory, discovered that these drugs interfere with a naturally occurring anticonvulsant in the brain, glycine, and that widely used anesthetics reverse this interfering effect.

David Mazer, Professor and Vice-Chair of Research in the Department of Anesthesia at University of Toronto and co-investigator on the study, says this research will change the way
'/>"/>

Contact: Nicole Bodnar
nicole.bodnar@utoronto.ca
416-978-5811
University of Toronto
Source:Eurekalert

Page: 1 2

Related biology news :

1. Early warning system for seizures could cut false alarms
2. Childhood virus infection linked to prolonged seizures with fever
3. Exposure to antibiotics linked to severity of allergic asthma: UBC research
4. Autism risk gene linked to differences in brain structure
5. Spontaneous gene glitches linked to autism risk with older dads
6. Dental X-rays linked to common brain tumor
7. Ocean acidification linked to larval oyster failure
8. First mass extinction linked to marine anoxia
9. Prenatal exposure to air pollution linked to childhood obesity
10. Knee injuries in women linked to motion, nervous system differences
11. Researchers discover first gene linked to missing spleen in newborns
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/5/2014)... associate professor of biology in the UTSA College ... the nation selected to receive a two-year $300,00 ... Exploratory Research (EAGER). The funding supports President Obama,s ... to create new technology that will demystify complex ... behaviors in neuroscience are broken into the interactions ...
(Date:11/4/2014)... (Philadelphia, PA) – Temple University School of Medicine ... Explorations winner, an initiative funded by the Bill ... MPH, Professor of Obstetrics, Gynecology and Reproductive Sciences; ... at Temple University School of Medicine will pursue ... titled "Maternal Blood Biomarkers to Assess Fetal Neurodevelopment.", ...
(Date:11/4/2014)... Lithuania , Nov. 4, 2014   ... technologies, today announced that the latest version of ... in the Ongoing MINEX evaluation organized ... of fingerprint algorithms using the INCITS 378 fingerprint ... mandatory requirement in public tenders in ...
Breaking Biology News(10 mins):UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3Temple University School of Medicine receives Grand Challenges Explorations grant 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 3
... TorontoResearchers at the University of Toronto, The Hospital ... University of British Columbia have identified a new treatment ... and an estimated 10% of common colds. The virus, ... most common reason for hospitalization of infants and children ...
... led by St. Jude Children,s Research Hospital scientists has ... childhood eye tumor retinoblastoma. Their work also settles a ... as scrambled as the developmental pathways at work in ... particular type of cell, researchers showed that retinoblastoma is ...
... A recent study suggests that parasites in fish, including ... impacts on fish health than has been assumed, and could ... land use changes cause salmon mortality. It,s not just ... research found, but their numbers that can build up over ...
Cached Biology News:Researchers map pathway of infection for a common, potentially life-threatening respiratory virus 2Childhood eye tumor made up of hybrid cells with jumbled development 2Childhood eye tumor made up of hybrid cells with jumbled development 3Parasite loads an underlying cause of salmon mortality, linked to land use changes 2
(Date:11/22/2014)... element of surprise has been a major advantage of ... Until now, epidemiologists had nothing to measure that might ... suboptimal responses to both the H1N1 pandemic of 2009 ... http://photos.prnewswire.com/prnh/20141121/160242 That virus advantage ... structural changes have been found that invariably to date ...
(Date:11/21/2014)... TRU-D SmartUVC LLC and its UK partners, Rapid Disinfection ... TRU-D SmartUVC, at FIS 2014 in Harrogate, England ... Stand 23. The conference, hosted by Federation of ... largest infection-related event of its kind and brings together more ... events of its type throughout the world. This annual event ...
(Date:11/21/2014)... November 20, 2014 Author Matthew J. ... to the Other Side” published as a tribute ... in the “Fiction: Short Story” category of the ... President and CEO of USA Book News, said this ... independent publishers, including Simon & Schuster, Penguin, John Wiley ...
(Date:11/21/2014)... (PRWEB) November 20, 2014 The November ... available as an open access journal featuring the following ... fluorescent proteins to preserve photoresponsiveness in the retina , ... fluorescent in situ hybridization using chromogenic substrates in zebrafish ... DNA, RNA, and protein electrophoresis , Nuclear ...
Breaking Biology Technology:Viruses' Advantage of Surprise is Lost 2TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 2TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 3Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 2Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 3Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 4BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 3
... November 2007, BARCELONA, Spain, October 9 ... 332 patients,with Overactive Bladder (OAB) and has been ... Spain, The Netherlands, Czech Republic, Hungary,Poland, Russia, South ... report the results of this trial during November. ...
... PARI Respiratory Equipment,s,breath-enhanced nebulizer, the PARI LC ... new COPD medication, Perforomist Inhalation Solution,that launched ... of Mylan Inc.,(NYSE: MYL ). ... for,long-term, twice-daily maintenance treatment of bronchoconstriction for,emphysema ...
... Solution, to Orthopedic Imaging, PARIS and ATLANTA, Oct. ... 510k clearance from the Food and Drug Administration,(FDA) to ... United States for 2D,imaging use. EOS 2D|3D technology ... images to be obtained with a low dose of ...
Cached Biology Technology:SALVAT has Completed Patient Enrollment in a Dose Finding Phase II Trial of SVT-40776 for the Treatment of Overactive Bladder 2PARI Respiratory's LC PLUS & PRONEB Ultra Deliver Dey, L.P.'s New COPD Therapy; Perforomist Launched Yesterday 2PARI Respiratory's LC PLUS & PRONEB Ultra Deliver Dey, L.P.'s New COPD Therapy; Perforomist Launched Yesterday 3PARI Respiratory's LC PLUS & PRONEB Ultra Deliver Dey, L.P.'s New COPD Therapy; Perforomist Launched Yesterday 4FDA Clears Biospace med's Revolutionary Low Dose Xray Imager 2FDA Clears Biospace med's Revolutionary Low Dose Xray Imager 3FDA Clears Biospace med's Revolutionary Low Dose Xray Imager 4
... us with target blotted protein on PVDF ... in water), The N-terminal sequence of proteins ... samples purified by HPLC or mono-and bidimensional ... difluoride) membranes using the well known EDMAN ...
Mycoplasma Removal Agent (MRA) has been developed for cell culture, to combat the widespread problems caused by contamination of cell cultures with mycoplasma....
... product contains 5 ml Dynabeads® ... the monoclonal BerEP4 against the ... cell adhesion molecule). Also available ... 2 x 10e7 MNC in ...
albumin from bovine serum (BSA), tetramethylrhodamine conjugate...
Biology Products: