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Seemingly suicidal stunt is normal rite of passage for immune cells
Date:10/20/2008

replication of DNA during cell division or the creation of reproductive cells like the sperm and the egg. Ionizing radiation and chemotherapy drugs also can cause similar damage to DNA. Finally, DNA strands from infectious agents that enter the cell can mimic damaged host DNA.

"It's entirely possible that some of these breaks are activating genetic mechanisms that are unrelated to DNA repair or cell survival, like the mechanisms we identified in lymphocytes," says Sleckman. "Understanding the broader scope of the cells' responses to DNA damage could potentially be important in a wide variety of contexts."


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Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

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