Navigation Links
Seeing kidney injury, as it happens
Date:1/31/2011

The current check for kidney disease is a simple blood test for serum creatinine, but it can take longer than two days for this metabolite to accumulate to levels that are significant enough to indicate kidney damage - and by then it may be too late to intervene.

To close the gap between injury and diagnosis, a team of basic scientists and physicians led by Dr. Jonathan Barasch, M.D., Ph.D., associate professor of medicine and cell biology, Dr. Neal Paragas, a postdoctoral fellow, and Dr. Andong Qiu, an associate research scientist at Columbia University Medical Center, has created a "reporter mouse" - a genetically engineered bioluminescent animal capable of illuminating the onset and the time course of kidney damage by the generation of light.

In a paper published online this month in the journal Nature Medicine, Drs. Barasch, Paragas and Qiu report a technique to detect in a living mouse the appearance of a protein that is activated only when the kidney is bombarded with stimuli that cause sudden kidney injury.

The NGAL (neutrophil gelatinase-associated lipocalin) gene was selected for the creation of the bioluminescent mouse because of the many clinical studies performed at Columbia and Cincinnati Children's Hospital by Drs. Barasch and P. Devarajan, at Kyoto University by Dr. K. Mori, and at the Charite' Universittsmedizin Berlin by Dr. K.M. Schmidt-Ott that show NGAL can report toxic cellular stresses rather than simple and reversible changes in kidney function.

Drs. Barasch, Paragas and Qiu also set out to determine whether NGAL met the rigorous criteria of a true "biomarker," which requires the simultaneous appearance of the protein at the site of organ damage and in the serum or urine in proportion to the stimulus - and within a timeframe that allows a physician to intervene in a clinically meaningful way.

"The hope is not only to show further evidence that NGAL immediately detects and measures kidney injury, but to design the fastest and most precise test that will allow physicians to make evidence-based and potentially lifesaving drug treatment decisions, watching the kidney in real time to see if therapies are working," Dr. Paragas said.


'/>"/>

Contact: Alex Lyda
alyda@columbia.edu
212-305-0820
Columbia University Medical Center
Source:Eurekalert

Related biology news :

1. Seeing the world differently
2. Hearing colors, seeing sounds: New research explores sensory overlap in the brain
3. Seeing melanoma
4. Seeing a bionic eye on medicines horizon
5. Seeing the hidden services of nature
6. Seeing the brain hear reveals surprises about how sound is processed
7. Seeing the forest through the trees and seeing the trees through the leaves
8. Seeing without looking
9. Seeing how evolutionary mechanisms yield biological diversity
10. Seeing family for the holidays? Scientists discover how the stress might kill you
11. Seeing is relieving
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2016)... June 2, 2016 The Department of ... awarded the 44 million US Dollar project, for the ... Plates including Personalization, Enrolment, and IT Infrastructure , ... the production and implementation of Identity Management Solutions. Numerous renowned ... Decatur was selected for the most ...
(Date:6/1/2016)... NEW YORK , June 1, 2016 ... Biometric Technology in Election Administration and Criminal Identification to ... According to a recently released TechSci Research report, " ... Sector, By Region, Competition Forecast and Opportunities, 2011 - ... $ 24.8 billion by 2021, on account of growing ...
(Date:5/16/2016)... NEW YORK , May 16, 2016   ... authentication solutions, today announced the opening of an IoT ... to strengthen and expand the development of embedded ... provides an unprecedented level of convenience and security with ... to authenticate one,s identity aside from DNA. EyeLock,s platform ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial spectrophotometers and ... and the 6000i models are higher end machines that use the more unconventional z-dimension ... light beam from the bottom of the cuvette holder. , FireflySci has developed ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... release of its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering ... retention in this eBook by providing practical tips, tools, and strategies for clinical ...
(Date:6/23/2016)... 23, 2016   Boston Biomedical , an ... designed to target cancer stemness pathways, announced that ... Orphan Drug Designation from the U.S. Food and ... cancer, including gastroesophageal junction (GEJ) cancer. Napabucasin is ... inhibit cancer stemness pathways by targeting STAT3, and ...
(Date:6/23/2016)... -- A person commits a crime, and the detective uses ... criminal down. An outbreak of foodborne illness makes ... uses DNA evidence to track down the bacteria that caused ... not. The FDA has increasingly used a complex, cutting-edge technology ... Put as simply as possible, whole genome sequencing is a ...
Breaking Biology Technology: