Navigation Links
Seeing kidney injury, as it happens
Date:1/31/2011

The current check for kidney disease is a simple blood test for serum creatinine, but it can take longer than two days for this metabolite to accumulate to levels that are significant enough to indicate kidney damage - and by then it may be too late to intervene.

To close the gap between injury and diagnosis, a team of basic scientists and physicians led by Dr. Jonathan Barasch, M.D., Ph.D., associate professor of medicine and cell biology, Dr. Neal Paragas, a postdoctoral fellow, and Dr. Andong Qiu, an associate research scientist at Columbia University Medical Center, has created a "reporter mouse" - a genetically engineered bioluminescent animal capable of illuminating the onset and the time course of kidney damage by the generation of light.

In a paper published online this month in the journal Nature Medicine, Drs. Barasch, Paragas and Qiu report a technique to detect in a living mouse the appearance of a protein that is activated only when the kidney is bombarded with stimuli that cause sudden kidney injury.

The NGAL (neutrophil gelatinase-associated lipocalin) gene was selected for the creation of the bioluminescent mouse because of the many clinical studies performed at Columbia and Cincinnati Children's Hospital by Drs. Barasch and P. Devarajan, at Kyoto University by Dr. K. Mori, and at the Charite' Universittsmedizin Berlin by Dr. K.M. Schmidt-Ott that show NGAL can report toxic cellular stresses rather than simple and reversible changes in kidney function.

Drs. Barasch, Paragas and Qiu also set out to determine whether NGAL met the rigorous criteria of a true "biomarker," which requires the simultaneous appearance of the protein at the site of organ damage and in the serum or urine in proportion to the stimulus - and within a timeframe that allows a physician to intervene in a clinically meaningful way.

"The hope is not only to show further evidence that NGAL immediately detects and measures kidney injury, but to design the fastest and most precise test that will allow physicians to make evidence-based and potentially lifesaving drug treatment decisions, watching the kidney in real time to see if therapies are working," Dr. Paragas said.


'/>"/>

Contact: Alex Lyda
alyda@columbia.edu
212-305-0820
Columbia University Medical Center
Source:Eurekalert

Related biology news :

1. Seeing the world differently
2. Hearing colors, seeing sounds: New research explores sensory overlap in the brain
3. Seeing melanoma
4. Seeing a bionic eye on medicines horizon
5. Seeing the hidden services of nature
6. Seeing the brain hear reveals surprises about how sound is processed
7. Seeing the forest through the trees and seeing the trees through the leaves
8. Seeing without looking
9. Seeing how evolutionary mechanisms yield biological diversity
10. Seeing family for the holidays? Scientists discover how the stress might kill you
11. Seeing is relieving
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... , Mar 24, 2017 Research and ... Access System Market Analysis & Trends - Industry Forecast to 2025" ... ... to grow at a CAGR of around 15.1% over the next ... This industry report analyzes the market estimates and forecasts for all ...
(Date:3/22/2017)... -- Vigilant Solutions , a vehicle location and ... today the appointment of retired FBI special agent ... development. Mr. Sheridan brings more than 21 ... on the aviation transportation sector, to his new role ... served as the Aviation Liaison Agent Coordinator (ALAC) in ...
(Date:3/9/2017)... , March 9, 2017 4Dx has publicly ... Lung Imaging Workshop at the University of Pennsylvania. Founder ... to deliver the latest data to world leaders in ... brings together leaders at the forefront of the industry ... imaging. "The quality of the imaging ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... ... April 20, 2017 , ... ... this new webinar will explore challenging patient cases when screening for direct oral ... there may be a need for bridging parental anticoagulation especially for those at ...
(Date:4/20/2017)... ... April 20, 2017 , ... USDM Life Sciences , the leading risk ... industries, is pleased to announce Holger Braemer as Vice President of its ... based in Germany. , Braemer is an integral part of USDM’s expansion of ...
(Date:4/20/2017)... , April 20, 2017 /PRNewswire/ - Prometic Life Sciences Inc. (TSX: ... results at the International Liver Congress ("ILC") 2017 of the ... Amsterdam on the positive effects of ... model of obesity and metabolic syndrome. ... According to Dr. Lyne Gagnon, Vice-President of R&D ...
(Date:4/20/2017)... ... April 20, 2017 , ... ... a unique intellectual property (IP) sharing and commercialization model. , The Center for ... A main component of this effort is bringing the IP to the attention ...
Breaking Biology Technology: