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Secrets of immune response illuminated in new study
Date:2/9/2012

immune response.

Experiments also demonstrated that not all bacterial flagellins are recognized by the inflammasomesE. coli flagellins, for example, are not. The reasons for this have yet to be fully explored. The team further speculates that the inflammasome system and its NOD-like receptors may have evolved not only to deal with pathogenic invaders but to carefully regulate the balance of commensal bacteria, keeping populations of healthy microbes in check.

The study was the fruit of a multi-institute collaboration, co-authored by researchers from Department of Microbiology and Immunology, The University of Melbourne, Australia; Department of Biochemistry, University of Lausanne, Epalinges, Switzerland; Department of Infectious Diseases & Pulmonary Medicine, Charit University Hospital, Berlin, Germany and the Ludwig Institute of Cancer Research, Heidelberg, Australia.

As Curtiss explains, the group's research findings lay the groundwork for future investigation: "We are now incorporating the findings from the current study to design a superior recombinant attenuated Salmonella vaccine strain with greatly enhanced ability to induce a CD8-dependent cellular immunity against viral, parasitic and bacterial pathogens in which a CD8 response is critical for successful control."


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Contact: Joseph Caspermeyer
Joseph.Caspermeyer@asu.edu
Arizona State University
Source:Eurekalert  

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Secrets of immune response illuminated in new study
Secrets of immune response illuminated in new study
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