Navigation Links
Secrets of immune response illuminated in new study
Date:2/9/2012

When disease-causing invaders like bacteria infect a human host, cells of various types swing into action, coordinating their activities to address the threat.

In new research appearing in this month's issue of the journal Nature Immunology, Roy Curtiss, director of the Center for Infectious Diseases and Vaccinology at the Biodesign Institute at Arizona State University, along with international collaborators, investigates the coordination of a particular type of immune response, involving the release of of IFN-λ a cell-signaling protein molecule known as a cytokine.

Molecules like IFN-λ have long been recognized as vital weapons in the immune system's arsenal against viral, bacterial and parasitic pathogens, as well as tumors. They are known as interferonsnamed for their ability to interfere with the functioning or replication of infectious agents. Communication between cells enabled by interferons can trigger the protective defenses of the immune system, which will attempt by various means to eradicate the infectious pathogen.

"The inception of this study was based on studies conducted in collaboration with the Richard Strugnell group at the University of Melbourne when it was shown that flagella produced by S. Typhimuriumand especially by a mutant generated by Shifeng Wang in our group, that hyper produced the flagellinwere superior in inducing a cascade in host cells leading to the production of NFκB," a protein complex that plays a key role in regulating the immune response to infection.

The cytokine IFN-λ is produced by a type of lymphocyte known as a memory CD8+ T cell. Memory T cells are a vital part of the adaptive immune system. Typically, they are activated and induced to proliferate when they come in contact with a specific antigen produced by the infectious agent and recognized by the T cell's antigen receptor. After their initial encounter with the unfamiliar invader, memory T cel
'/>"/>

Contact: Joseph Caspermeyer
Joseph.Caspermeyer@asu.edu
Arizona State University
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Scientists look to microbes to unlock Earths deep secrets
2. Swarms of bees could unlock secrets to human brains
3. Learning secrets of worlds most common organic compound driving research for biofuels
4. As the worm turns, its secrets are revealed
5. Beetle bling: Researchers discover optical secrets of metallic beetles
6. MSU lands $4.1 million grant to unlock plants biochemistry secrets
7. Secrets of a precision protein machine
8. Breaking the mucus barrier unveils cancer cell secrets
9. Uncovering the genome secrets of the Blackleg fungus
10. A pesky bacterial slime reveals its survival secrets
11. Unlocking the secrets of a plants light sensitivity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Secrets of immune response illuminated in new study
(Date:11/15/2014)... YORK , Nov. 13, 2014  While we may ... technology Doctor McCoy used in "Star Trek" to gain instant ... tools designed to work with smartphones and tablets for monitoring ... of the healthcare world. This may seem a tad Orwellian ... ready to adopt some of these technological opportunities into their ...
(Date:11/7/2014)... conjunction with the Glendale and ... the Verdugos has announced the " GLENDALE - ... to keep the Verdugo Regional Crime Lab operational after its ... existence, the Lab has processed more than 400 DNA samples, ... "Because our number one priority is the wellbeing of ...
(Date:11/6/2014)... - Insilico Medicine, Inc, a Baltimore-based bioinformatics company ... diseases announced a research collaboration with the international ... Inc (OTC: CSBR). , "There are many companies ... Champions Oncology,s TumorGraft technology is unique in a ... experimentally generating vast amounts of valuable data. Our ...
Breaking Biology News(10 mins):Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2
... have resolved the debate over the mechanisms involved in the ... Research findings, published in the journal PNAS , ... this shut-down process to ensure that viruses and other pathogens ... harm. Previous research has shown that when cells divide, ...
... Huntington Beach, CAThe Association for Chemoreception Sciences (AChemS), a US-based ... 500 scientists are gathering to present new information on the ... nutrition, and social interactions in humans as ... in our daily lives. These ...
... dinosaurs that lived within Arctic latitudes approximately 70 million ... of migrating to more southern latitudes, a recent study ... of Nature and Science in Dallas and Temple University ... Were Perennial Polar Residents," in the April issue of ...
Cached Biology News:Study resolves debate on human cell shut-down process 2Smell and taste experts to discuss new discoveries 2Smell and taste experts to discuss new discoveries 3Smell and taste experts to discuss new discoveries 4Duck-billed dinosaurs endured long, dark polar winters 2Duck-billed dinosaurs endured long, dark polar winters 3
(Date:11/22/2014)... 21, 2014 RURO, Inc., a ... has released Limfinity® version 5.1.4. , RURO’s deployment ... Limfinity® than ever in RURO’s 8 year history. ... framework enhancement. Limfinity® version 5.1.4 is the perfect ... beyond bug fixes! , Limfinity® 5.1.4 release highlights ...
(Date:11/22/2014)... -- The element of surprise has been a major advantage ... warning. Until now, epidemiologists had nothing to measure that ... in suboptimal responses to both the H1N1 pandemic of ... - http://photos.prnewswire.com/prnh/20141121/160242 That virus ... gene structural changes have been found that invariably to ...
(Date:11/21/2014)... 19, 2014 The science of light ... shared with more than 200 primary students in a ... the University of Otago Physics Department and funded by ... students, members of the university’s OSA/SPIE Student Chapter visited ... September, giving children from small, rural schools hands-on lessons ...
(Date:11/21/2014)... The report, "Synthetic Biology Market ... kits), Technology (Bioinformatics, Nanotechnology, Gene Synthesis, Cloning ... - Global Forecast to 2018", analyses and ... and challenges. , Browse 99 market data ... pages and in-depth TOC of the global ...
Breaking Biology Technology:RURO Announces Limfinity® version 5.1.4 2Viruses' Advantage of Surprise is Lost 2Optics and photonics outreach programs share science, spark fascination with light 2Optics and photonics outreach programs share science, spark fascination with light 3Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 2Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 3Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 4
... Prepare your probe in less , ... Ideal for siRNA/miRNA studies , , ... activity RNA probes for RPA, Northern, Southern, or in situ hybridization , ... No cloning required , With ...
... Reagents and , ... Superior identification of target cells provided ... Designed for use , ... Compatible with Arcturus LCM Systems , Use with , ...
... Now it's easy to make your RNA free of genomic DNA , ... , & Removal Reagents contain RNase-free DNase, ... to ensure safe, complete removal of , ... DNase Removal Reagent which, after digestion, eliminates DNase in , ...
Cached Biology Technology:Prepare siRNA and miRNA Probes in Just 1 Hour 2Prepare siRNA and miRNA Probes in Just 1 Hour 3Protect RNA and Improve Target Cell Identification 2Protect RNA and Improve Target Cell Identification 3Protect RNA and Improve Target Cell Identification 4Protect RNA and Improve Target Cell Identification 5Protect RNA and Improve Target Cell Identification 6DNA-free A NEW Method to Remove DNA 2DNA-free A NEW Method to Remove DNA 3DNA-free A NEW Method to Remove DNA 4DNA-free A NEW Method to Remove DNA 5DNA-free A NEW Method to Remove DNA 6DNA-free A NEW Method to Remove DNA 7DNA-free A NEW Method to Remove DNA 8