echanical force and the identity of the analogous human molecules that confer gentle touch sensitivity in people.
The discovery is a good example of basic brain research paving the way toward answering such questions. UCSF is a world leader in the neurosciences, carrying out research that spans the spectrum from fundamental questions of how the brain works to the clinical development of new drugs and precision tools to address brain diseases; educating the next generation of neuroscientists, neurologists and neurosurgeons; and offering excellent patient care for neurological diseases.
Why is Touch Still Such a Mystery?
Though it is fundamental to our experience of the world, our sense of gentle touch has been the least well understood of our senses scientifically, because, unlike with vision or taste, scientists have not known the identity of the molecules that mediate it.
Scientists generally feel that, like those other senses, the sense of touch is governed by peripheral nerve fibers stretching from the spine to nerve endings all over the body. Special molecules in these nerve endings detect the mechanical movement of the skin surrounding them when it is touched, and they respond by opening and allowing ions to rush in. The nerve cell registers this response, and if the signal is strong enough, it will fire, signaling the gentle touch to the brain.
What has been missing from the picture, however, are the details of this process. The new finding is a milestone in that it defines the exact nerves and uncovers the identity of the NOMPC channel, one of the major molecular players involvedat least in flies.
Jan and his colleagues made this discovery through an unusual route. They were looking at the basic physiology of the developing fruit fly, examining how class III neurons develop in larvae. They noticed that when these cells developed in the insects, their nerve endings would always become branches into
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| Contact: Jason Socrates Bardi jason.bardi@ucsf.edu 415-502-4608 University of California - San Francisco Source:Eurekalert |
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