Navigation Links
Second-generation device more effective in capturing circulating tumor cells
Date:10/12/2010

sing samples through a chamber lined with a herringbone pattern of grooves an approach developed elsewhere for quickly mixing independent streams of fluid would generate a more chaotic flow that could significantly increase the number of captured cells.

The HB-Chip also can process larger-volume blood samples, increasing the ability to find rare CTCs. The microchip is mounted on a standard glass slide, which allows the use of standard pathology tests to identify cancer cells; and the device can be easily opened, giving access to CTCs for additional testing and growth in culture. Experiments comparing the HB-Chip to the CTC-chip found the new device captured more than 90 percent of cancer cells introduced into blood samples a 25 percent improvement over the CTC-chip. Tests of samples from cancer patients found the redesigned device at least as effective as the original.

The HB-Chip also captured clusters of 4 to 12 CTCs from several patient samples but not from samples to which cancer cells had been added. No previous technology for capturing CTCs has ever found such clumps of tumor cells. "These clusters may have broken off from the original tumor, or they might represent proliferation of CTCs within the circulation," says Mehmet Toner, PhD, director of the BioMicroElectroMechanical Systems Resource Center in the MGH Center for Engineering in Medicine, the paper's senior author. "Further study of these clusters could provide valuable insight in the metastatic process."

Daniel Haber MD PhD, director of the MGH Cancer Center and a co-author of the study, says, "This new technology is a powerful platform that will enable increasingly sophisticated analyses of metastasis and support clinical research in targeted cancer therapies."

While the MGH has filed a patent for the HB-Chip, the research team will continue to develop the technology before potential licensing is explored. The study was supported by grants from S
'/>"/>

Contact: Katie Marquedant
kmarquedant@partners.org
617-726-0337
Massachusetts General Hospital
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. De La Rue Provides Second-Generation ePassport for Malta
2. Kount Receives Patent for Device Fingerprinting
3. Nanodiamond drug device could transform cancer treatment
4. Caltech engineers build firast-ever multi-input plug-and-play synthetic RNA device
5. Linking Proteins, Wires, Dots, and Molecules into Useful Devices
6. NC State finds new nanomaterial could be breakthrough for implantable medical devices
7. Futronic Launches FS22 Fingerprint Access Control Device
8. BIO-key(R) Granted Patent for Trusted Biometric Device Security Solution
9. NIST-Cornell team builds worlds first nanofluidic device with complex 3-D surfaces
10. Device protects transplanted pancreatic cells from the immune system
11. Chemical found in medical devices impairs heart function
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Second-generation device more effective in capturing circulating tumor cells
(Date:11/7/2014)... Dr. Debra Auguste, associate professor, biomedical engineering, in ... College of New York, have identified a molecule ... of the most aggressive forms of breast cancer. ... high mortality rate owing to aggressive proliferation and ... However, Professor Auguste,s team, discovered the overexpression of ...
(Date:11/6/2014)... that predator runs so fast that it essentially blinds itself. ... fastest creature on Earth. Some of these half-inch-long beetles cover ... per hour). The fastest human can do about five body ... a person would have to hit 480 miles per hour. ... speeds, everything becomes a blur. They can,t gather enough light ...
(Date:11/4/2014)... Nov. 5, 2014 – University of Utah engineers developed ... help jet fuel produce electricity without needing to ignite ... to power portable electronics, off-grid power and sensors. , ... in the American Chemical Society journal ACS Catalysis ... a chemical reaction between a fuel and an oxygen-rich ...
Breaking Biology News(10 mins):The tiger beetle: Too fast to see 2Jet-fueled electricity at room temperature 2
... An international team led by scientists at The ... and Albert Einstein College of Medicine of Yeshiva University ... attacks the tuberculosis (TB) bacterium in two different ways. ... one of the major global health crises of our ...
... professors in Wayne State University,s Department of Physics kicked ... for Undergraduates (REU) program. This program aims to give ... and in particle and nuclear physics. According ... State,s College of Liberal of Arts, principal investigator and ...
... foundations with more modern elements. Using this same approachbut ... Dietrich School of Arts and Sciences have designed a ... storage, and gas transport more efficient and at a ... issue of the Journal of the American Chemical ...
Cached Biology News:New compound excels at killing persistent and drug-resistant tuberculosis 2New compound excels at killing persistent and drug-resistant tuberculosis 3New compound excels at killing persistent and drug-resistant tuberculosis 4Wayne State welcomes undergraduates from around the US for physics research experience 2'Chemical architects' build materials with potential applications in drug delivery and gas storage 2
(Date:11/27/2014)... The Europe Thermal Protective Clothing market report ... revenue forecasts. It estimates the market to reach ... of 7.5%, from 2013 to 2018. , Browse ... Clothing market report for a glimpse of the ... tables and figures. , http://www.micromarketmonitor.com/market/europe-thermal-protective-clothing-5957050557.html , ...
(Date:11/27/2014)... USA (PRWEB) November 26, 2014 Biomedical ... accuracy, additive systems to enable 3D manufacture at the ... road conditions are among finalists in nine categories for ... The awards are sponsored by SPIE, the international ... Media . , Winners will be announced by industry ...
(Date:11/26/2014)... Chicago, IL (PRWEB) November 26, 2014 ... is giving customers a bevy of last-minute Thanksgiving ... coupon codes and offers across all product lines this ... Thanksgiving. , Thanksgiving, Black Friday, and Cyber Monday ... expressing its' own thanks to both loyal customers and ...
(Date:11/26/2014)... (PRWEB) November 26, 2014 The ... City’s award-winning technology innovation centers, announced today that ... closing on December 1st. “Do you have a ... so, I want to know about it. AccelerateBaltimore ... idea to product in just 13 weeks.” ...
Breaking Biology Technology:The Europe Thermal Protective Clothing market is estimated to grow up to $577.9 million by 2018 - Report by MicroMarket Monitor 2The Europe Thermal Protective Clothing market is estimated to grow up to $577.9 million by 2018 - Report by MicroMarket Monitor 3Finalists Named for 2015 Prism Awards for Photonics Innovation 2Finalists Named for 2015 Prism Awards for Photonics Innovation 3Finalists Named for 2015 Prism Awards for Photonics Innovation 4Finalists Named for 2015 Prism Awards for Photonics Innovation 5DNA Spectrum Offers Last Minute Thanksgiving Coupons 2DNA Spectrum Offers Last Minute Thanksgiving Coupons 3AccelerateBaltimore Applications to Close in 6 Days 2AccelerateBaltimore Applications to Close in 6 Days 3
... Coalition,s Annual Meeting, FREMONT, Calif., Sept. 8 ... announced today that a,team of scientists at Stanford University ... at the Annual General Meeting of the,PAD Coalition. Led ... Eric T.,Fung, Chief Scientific Officer at Vermillion, Inc., the ...
... Sept. 8 /PRNewswire-FirstCall/ - Oncolytics Biotech Inc.,("Oncolytics") (TSX:ONC, ... enrolment in a Phase 2 clinical trial using ... in patients with advanced head and neck cancers. ... Cancer Therapy & Research Center,(CTRC) at The University ...
... International,Inc. (Nasdaq: CHDX ), a leading independent American provider ... China, today,announced that the Company will appear at the following ... held at the Grand Hyatt Hotel ... available for this event. -- ...
Cached Biology Technology:Vermillion and Stanford Scientists Receive 'Best Research Award' From the PAD Coalition 2Vermillion and Stanford Scientists Receive 'Best Research Award' From the PAD Coalition 3Oncolytics Biotech Inc. Starts Patient Enrolment in U.S. Phase 2 Clinical Trial Investigating REOLYSIN(R) in Combination with Paclitaxel and Carboplatin 2Oncolytics Biotech Inc. Starts Patient Enrolment in U.S. Phase 2 Clinical Trial Investigating REOLYSIN(R) in Combination with Paclitaxel and Carboplatin 3Chindex International, Inc. Announces Appearances at Upcoming Investor Conferences 2Chindex International, Inc. Announces Appearances at Upcoming Investor Conferences 3
Bovine Aortic Smooth Muscle Cells (BAOSMC) (>500,000 cells)...
Black Polypropylene 384 Round Well Plate 70/Box...
The improved design and new mechanical solutions of Finnpipette Focus Multichannel Plus improves accuracy and precision.In these low volume multichannel pipettes, the super blow-out function ensures ...
... Synucleins are small, soluble proteins expressed ... tumors. The family includes three known proteins: ... The alpha and beta synuclein proteins are ... are seen mainly in presynaptic terminals. ...
Biology Products: