Navigation Links
Second-generation device more effective in capturing circulating tumor cells
Date:10/12/2010

A redesigned version of the CTC-Chip a microchip-based device for capturing rare circulating tumor cells (CTCs) appears to be more effective and should be easier to manufacture than the original. Called the HB-(herringbone) Chip, the new device also may provide more comprehensive and easily accessible data from captured tumor cells. Massachusetts General Hospital (MGH) researchers including members of the team that developed the CTC-Chip report the second-generation device in a Proceedings of the National Academy of Sciences paper that has been released online.

"The originally CTC-Chip worked wonderfully in a small-scale laboratory setting, but limitations arose when we attempted to increase production for larger clinical studies. The new device performs as well or better than the previous technology with several additional benefits," says Shannon Stott, PhD, of the MGH Center for Engineering in Medicine, co-lead author of the PNAS paper. "It also was able to capture something that had never been seen using either the CTC-chip or the most prevalent previous technology small clusters of CTCs, the significance of which we need to study."

CTCs are living solid tumor cells found at extremely low levels in the bloodstream. Until the 2007 development of the CTC-chip by researchers from the MGH Cancer Center and the Center for Engineering in Medicine, it was not possible to get information from CTCs that would be useful for clinical decision making.

In the original device, patient blood samples are passed over a silicon chip covered with microscopic posts coated with an antibody that binds to most tumor cells. Not only did this design proved challenging to manufacture reliably and cost-effectively, but the smooth flow of blood around the microposts also limited the number of CTCs that came into contact with the antibody-covered surfaces. In their search to increase the capture of CTCs, the researchers found that pas
'/>"/>

Contact: Katie Marquedant
kmarquedant@partners.org
617-726-0337
Massachusetts General Hospital
Source:Eurekalert  

0

GOOD

Page: 1 2 3

Related biology news :

1. De La Rue Provides Second-Generation ePassport for Malta
2. Kount Receives Patent for Device Fingerprinting
3. Nanodiamond drug device could transform cancer treatment
4. Caltech engineers build firast-ever multi-input plug-and-play synthetic RNA device
5. Linking Proteins, Wires, Dots, and Molecules into Useful Devices
6. NC State finds new nanomaterial could be breakthrough for implantable medical devices
7. Futronic Launches FS22 Fingerprint Access Control Device
8. BIO-key(R) Granted Patent for Trusted Biometric Device Security Solution
9. NIST-Cornell team builds worlds first nanofluidic device with complex 3-D surfaces
10. Device protects transplanted pancreatic cells from the immune system
11. Chemical found in medical devices impairs heart function
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Second-generation device more effective in capturing circulating tumor cells
(Date:6/18/2013)... been awarded a $394,300 grant from the Tarrant ... flow in the new facilities of the 150-mile ... associate professor of civil engineering, will investigate the ... the water in an effort to eliminate biological ... Adding monochloramine is widely practiced throughout the United ...
(Date:6/18/2013)... Obar, Ph.D., Department of Immunology and Infectious Diseases, Montana ... Young Investigator Award for his research on factors affecting ... , Obar earned his B.A. in Microbiology from ... complete his Ph.D. in Microbiology and Immunology from Dartmouth ... research in Edward Usherwood,s laboratory at the Geisel School ...
(Date:6/18/2013)... internationally recognized feline experts including veterinarians and feline scientists ... Lincoln, U.K. and Dr Ilona Rodan, Director of Cat ... Society of Feline Medicine (ISFM) and the American Association ... owners and those working with cats on how to ... new guidelines appear in the Journal of Feline ...
Breaking Biology News(10 mins):UT Arlington research to benefit quality, flow in 150-mile Integrated Pipeline 2The American Society for Microbiology honors Joshua Obar 2Feline behavior experts release guidelines to improve the welfare of cats 2
... rise, and the loss of sand dune plant habitats" ... to better understand the impacts of development and coastal ... the ever-shrinking strip of habitat between land and the ... simulated varying levels of sea-level rise to understand the ...
... body, a virus such as HIV invades body cells by ... inside the cell, the invading microbe's genetic material takes over, ... copies of the virus, which then spill out to invade ... once a virus begins fusing with a cell's membrane, infection ...
... dramatic reduction in the impact of malaria is in prospect ... Guinea early next year. Success in the trial would open ... with this debilitating and often fatal disease - over 500,000,000 ... Medical Research is collaborating with the Papua New Guinea Institute ...
Cached Biology News:Squeezing out dune plants 2Several minute intermediate stage in virus-cell fusion discovered; opportunity for drug development 2Several minute intermediate stage in virus-cell fusion discovered; opportunity for drug development 3Old drug, new tricks: Prospects for slashing the impact of malaria 2
(Date:6/19/2013)... Express Diagnostics Int’l, Inc., manufacturer of DrugCheck® ... has received Class III medical device license approval from ... NxStep Onsite Drug Screen Cup in Canada. Class ... in near-patient settings, such as physicians’ offices. , The ... Class III approval for 24 different drugs and detection ...
(Date:6/18/2013)... (PRWEB) June 18, 2013 In support ... sustainability, the Consulate General of Switzerland in New York ... Switzerland’s MS Tûranor PlanetSolar , to Manhattan. ... its DeepWater Expedition 2013 tour with scientists on board ... Capitain Gérard d’Aboville, runs exclusively on energy from the ...
(Date:6/18/2013)... (PRWEB) June 18, 2013 DuPont welcomes ... the 11th annual DuPont National AgriScience Teachers Ambassador Academy ... in Chestertown, Md. , The NATAA ... DuPont and is a special project of the ... of Agricultural Educators (NAAE) . The highly recommended ...
(Date:6/18/2013)... Edison Investment Research, ... the initiation of full coverage of BioAlliance ... and marketing products for orphan oncology and ... (Logo: http://photos.prnewswire.com/prnh/20130417/608168) Edison has today ... merits of BioAlliance Pharma, focusing in particular ...
Breaking Biology Technology:Express Diagnostics’ DrugCheck® On-site Test Cup Receives Health Canada Class III Medical Device Approval 2Express Diagnostics’ DrugCheck® On-site Test Cup Receives Health Canada Class III Medical Device Approval 3Switzerland’s MS Tûranor PlanetSolar, the World’s Largest Solar Boat, Arrives in New York City 2Switzerland’s MS Tûranor PlanetSolar, the World’s Largest Solar Boat, Arrives in New York City 3Switzerland’s MS Tûranor PlanetSolar, the World’s Largest Solar Boat, Arrives in New York City 4DuPont Sponsors National AgriScience Ambassador Academy 2DuPont Sponsors National AgriScience Ambassador Academy 3Edison Expands French Healthcare Sector Coverage With Initiation of Coverage on BioAlliance Pharma 2Edison Expands French Healthcare Sector Coverage With Initiation of Coverage on BioAlliance Pharma 3
... WinnersDENVER, March 30 Cochlear Americas, the world,s ... winners of the 2009 Graeme Clark Scholarship awards. ... has recognized the remarkable achievements of individuals who ... small electronic device that can provide a sense ...
... leading campus recruitment company, has announced the official ... new website is designed for students, recent graduates, ... the biotechnology, pharmaceutical, and life sciences industries. With ... more people are considering a career in these ...
... support for expected Phase 3 programCRANBURY, N.J., March 28 ... today positive results from its ongoing Phase 2 extension ... Fabry disease. The results will be presented at ... Meeting in Tampa, FL. Phase 2 Extension ...
Cached Biology Technology:Cochlear Americas Provides Support for Cochlear Implant Recipients to Pursue Higher Education 2Cochlear Americas Provides Support for Cochlear Implant Recipients to Pursue Higher Education 3Cochlear Americas Provides Support for Cochlear Implant Recipients to Pursue Higher Education 4Cochlear Americas Provides Support for Cochlear Implant Recipients to Pursue Higher Education 5Recent Graduates Finding BioTech & Pharmaceutical Jobs Easier Than Ever With The Launch of CampusRXBio 2Recent Graduates Finding BioTech & Pharmaceutical Jobs Easier Than Ever With The Launch of CampusRXBio 3Amicus Therapeutics Presents Positive Results From Phase 2 Extension Study of Amigal(TM) for Fabry Disease at ACMG 2009 Annual Meeting 2Amicus Therapeutics Presents Positive Results From Phase 2 Extension Study of Amigal(TM) for Fabry Disease at ACMG 2009 Annual Meeting 3Amicus Therapeutics Presents Positive Results From Phase 2 Extension Study of Amigal(TM) for Fabry Disease at ACMG 2009 Annual Meeting 4Amicus Therapeutics Presents Positive Results From Phase 2 Extension Study of Amigal(TM) for Fabry Disease at ACMG 2009 Annual Meeting 5
Donor feline serum and plasma...
Consists of 4 separate 100mM solutions (ATP,GTP,CTP and UTP pH 7.5) as sodium salts. 98% Pure by HPLC...
HAS1 (C-14)...
Donor feline serum and plasma...
Biology Products: