Navigation Links
Searching for causes of neural disconnection in schizophrenia
Date:7/6/2010

Philadelphia, 6 July, 2010 - Dendritic spines act as hubs for communication between nerve cells. Reductions in spines may contribute to a lack of coordination in activity between brain regions. This structural abnormality is particularly relevant in schizophrenia, where pyramidal neurons located in layer 3, the principal cell type receiving communication from other brain regions, have fewer dendritic spines.

Studying this phenomenon further, researchers at the University of Pittsburgh now provide new insights into the dendritic spine deficits in schizophrenia. Drs. Masayuki Ide and David Lewis studied postmortem brain tissue of individuals diagnosed with schizophrenia and compared it to tissue from healthy individuals.

They found that the expression levels of two gene products, CDC42EP3 and septin 7, were higher and lower, respectively, in tissue from those with schizophrenia. CDC42EP3 and septin 7 play important roles in regulating spine plasticity. Since CDC42EP3 is preferentially expressed in layer 3, the findings suggest that the altered expression of these transcripts may contribute to the layer-specific deficits in dendritic spines associated with schizophrenia.

"We still have a long way to go to fully understand the neurobiology of schizophrenia. An important step in this process will be to begin to learn what we can about neural structure and chemistry from postmortem brain tissue from individuals diagnosed with schizophrenia," commented Dr. John Krystal, Editor of Biological Psychiatry. "These studies may help, ultimately, to develop new treatments that attempt to prevent or reverse these disturbances in brain structure associated with schizophrenia."

Dr. Lewis agreed, remarking that "These findings provide a potential basis for novel treatments for schizophrenia, and for preemptive interventions for individuals who are at high risk for the illness."


'/>"/>

Contact: Maureen Hunter
m.hunter@elsevier.com
215-239-3674
Elsevier
Source:Eurekalert

Page: 1

Related biology news :

1. Searching for brains defenses to ward off infections, prevent memory loss
2. Searching for genes behind a trait
3. Biochemist researching computer models of protein structure that help high school, college students
4. Searching for an interglacial on Greenland
5. Searching for pollution in the Caribbean
6. New MegaMatcher Accelerator Boosts Speed for High-Volume Biometric Identification and Database Duplicate Searching
7. Mystery unraveled: How asbestos causes cancer
8. Research in which the University of Navarra participated provides new clues to causes of leukemia
9. Study finds dirty air in California causes millions worth of medical care each year
10. Brain study offers insight into causes of autism
11. Comprehensive study using bioinformatics predicts the molecular causes of many genetic diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2017)... , April 17, 2017 NXT-ID, Inc. ... company, announces the filing of its 2016 Annual Report on Form ... Exchange Commission. ... Form 10-K is available in the Investor Relations section of the ... on the SEC,s website at http://www.sec.gov . 2016 ...
(Date:4/11/2017)... -- Research and Markets has announced the addition of ... offering. ... market to grow at a CAGR of 30.37% during the period ... has been prepared based on an in-depth market analysis with inputs ... growth prospects over the coming years. The report also includes a ...
(Date:4/5/2017)... -- The Allen Institute for Cell Science today announces the ... and dynamic digital window into the human cell. The ... of deep learning to create predictive models of cell ... growing suite of powerful tools. The Allen Cell Explorer ... available resources created and shared by the Allen Institute ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased ... of over 5.5 million people each year. Especially those living in larger cities are ... - based in one of the most pollution-affected countries globally - decided to take ...
(Date:10/11/2017)... Florida (PRWEB) , ... October 11, 2017 , ... ... Drug Administration (FDA) has granted orphan drug designation to SBT-100, its novel anti-STAT3 ... for the treatment of osteosarcoma. SBT-100 is able to cross the cell membrane ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights that give ... Liposomal Nanoparticle), a technology developed in collaboration with Children’s Hospital Los Angeles ...
(Date:10/10/2017)... ... , ... Dr. Bob Harman, founder and CEO of VetStem Biopharma, Inc. ... The event entitled “Stem Cells and Their Regenerative Powers,” was held on August ... MPVM was joined by two human doctors: Peter B. Hanson, M.D., Chief of Orthopedic ...
Breaking Biology Technology: