Navigation Links
Search tool for gene expression databases could uncover therapeutic targets, biological processes
Date:10/1/2013

PITTSBURGHA new computational tool developed by U.S. and Israeli scientists will help scientists exploit the massive databases of gene expression experimental results that have been created over the past decade. Researchers say it could uncover new links between diseases and treatments and provide new insights into biological processes.

The team, headed by Ziv Bar-Joseph of Carnegie Mellon University, reports in the October issue of the journal Nature Methods that the tool, called ExpressionBlast, enables searches based directly on experimental values, rather than keywords.

The researchers already have used ExpressionBlast to uncover intriguing clues about SIRT6, the first gene shown to extend lifespan in mice and thus a potentially important drug target. By mining experimental data stored in a public repository called the Gene Expression Omnibus (GEO) maintained by the National Center for Biotechnology Information, they found that SIRT6 may be involved with functions that include immune response, metabolism and the regulation of gender-specific genes.

"Because so little is known about SIRT6, it would be difficult to search the hundreds of thousands of GEO datasets using keywords and, without other guidance, it would be practically impossible to find other experiments with gene expression patterns similar to SIRT6," said Bar-Joseph, an associate professor of computational biology and machine learning. "ExpressionBlast enabled us to take SIRT6 gene expression data from just two mouse experiments and find other experimental data in GEO with similar expression patterns."

The tool is available online, http://www.expression.cs.cmu.edu/. The search engine enables researchers to search for expression patterns that are similar or opposite to their own results and can search within and across species. Guy Zinman, Shoshana Naiman, Yariv Kanfi and Haim Cohen of Bar-Ilan Universi
'/>"/>

Contact: Byron Spice
bspice@cs.cmu.edu
412-268-9068
Carnegie Mellon University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Rensselaer researchers propose new theory to explain seeds of life in asteroids
2. Parkinsons Surgery Research wins NSF Grant
3. UT Dallas researchers find early success in new treatment for stroke recovery
4. LSUHSCS OCHOA 1 of 10 chosen by NIH director for Transformative Research Award
5. Biomedical Advanced Research and Development Authority (BARDA) Exercises Option with Pfenex Inc. To Extend Contract and Increase Funding for the Development of a Recombinant Protective Antigen (rPA) Based Anthrax Vaccine
6. University of Utah researchers receive NIH Directors New Innovator Award
7. $1.5 million NCI Grant to aid Huntsman Cancer Institute researcher study melanoma, sun damage link
8. UC Davis researchers discover a biological link between diabetes and heart disease
9. Research shows how aspirin may act on blood platelets to improve survival in colon cancer patients
10. Latest research suggests moderate coffee consumption is not associated with increased CVD risk
11. U.Va. researcher: Methane out, carbon dioxide in?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... Wash. -- Like a hungry diner ripping open a ... into electricity must tear open a hydrogen molecule. Now ... holding onto the two halves of its hydrogen feast. ... how to make the catalyst work better for alternative ... scientists have shown precisely where the hydrogen halves end ...
(Date:4/23/2014)... A team of researchers in Korea who ... brains of nonhuman primates and assessed cell survival ... that the hNSCs had differentiated into neurons at ... The study will be published in a future ... currently freely available on-line as an unedited early ...
(Date:4/23/2014)... found evidence of an interaction between prenatal smoking ... in children, especially in girls. , "The interesting ... prenatal smoking will have behavioral problems. Some ... Assistant Professor at Sam Houston State University, College ... study. "One possible explanation for this is ...
Breaking Biology News(10 mins):Halving hydrogen 2Halving hydrogen 3Halving hydrogen 4Study finds long-term survival of human neural stem cells transplanted into primate brain 2Genetics risk, prenatal smoking may predict behavioral problems 2
... likely require an old ally Mother Nature and ... for cutting greenhouse gas emissions 20% by 2020, according ... says that despite rising population and affluence, the EU ... will likely require more than energy savings, new technologies ...
... Australia now have greater access to the Japanese market ... of Primary Industries (DPI). Trials undertaken at NSW ... at temperatures of 2 or 3C can effectively kill ... days. Cold treatment at these temperatures provides greater ...
... still some places available on two international workshops for ... Netherlands) is organizing at the start of 2008. The ... sanitary engineering,. The two workshops are to be held ... or attended seperately. The Delft University of Technology ...
Cached Biology News:European Union forests expanding, absorbing carbon at surprisingly high rate: study 2European Union forests expanding, absorbing carbon at surprisingly high rate: study 3Cold treatment opens doors for citrus exports to Japan 2
(Date:1/14/2014)... DC (PRWEB) January 14, 2014 Carahsoft ... for Thursday, January 23, 2014 at 2pm EST (11am ... Knowledge.” The topic focuses on how technology can turn ... critical decisions for government agencies. The online webinar will ...
(Date:1/14/2014)... pet owners drew up their lists of New Year,s resolutions for ... of my furry companion." Nowadays there are pet salons, dog and ... take the little canine or feline darlings along wherever mommy or ... pricey toys at the pet store. But anyone who has ever ...
(Date:1/14/2014)... DIEGO and BETHESDA, Md. ... are joining together with two institutes from the National ... reliable tools for bringing safer, more effective treatments to ... the National Center for Advancing Translational Sciences (NCATS) and ...
(Date:1/14/2014)... 14, 2014  RXi Pharmaceuticals Corporation (OTCQX: RXII), a ... innovative therapies addressing major unmet medical needs using ... Notice of Allowance from the United States Patent ... compounds (sd-rxRNA®), for the treatment of fibrosis. The ...
Breaking Biology Technology:Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3
... Crosse, Wis. -- Firstlogic Inc. , a ... Corp. approved technology from Firstlogics Information Quality ... ,Oracle Warehouse Builder is a business intelligence integration ... allows users to design their business intelligence application ...
... medial errors, improve patient safety and run a ... to automate the costly processes of data collection, ... 5 percent of healthcare organizations research outcome and ... revenue enhancements and quality of life improvements associated ...
... reducing surgery delays and controlling instrument and staff costs ... trays by using a new surgical instrument management system ... ,Gundersen Lutheran operates a teaching hospital with 325 licensed ... practices, community clinics, eye clinics and pharmacies. It has ...
Cached Biology Technology:Real-Time Data Warehouse Benefits Healthcare Providers 2Real-Time Data Warehouse Benefits Healthcare Providers 3Gunderson Lutheran Implements Instrument Management Systems 2
... WinList come straight from the folks who ... automatic region positioning, N-Stat regions, and presentation-quality ... thoughtful conversations, and careful design. Of course, ... are still there, too. WinList leads the ...
Insect Cell Lysis Buffer 50 ml...
Recognizes the VZV nucleocapsid by indirect immunofluorescence and immunoprecipitation. Shows cross-reactivity to HSV....
Rabbit polyclonal to Orexin Prepro ( Abpromise for all tested applications). entrezGeneID: 3060 SwissProtID: O43612...
Biology Products: