Navigation Links
Sea creatures' sex protein provides new insight into diabetes
Date:3/22/2010

A genetic accident in the sea more than 500 million years ago has provided new insight into diabetes, according to research from Queen Mary, University of London.

Professor Maurice Elphick, from Queen Mary's School of Biological and Chemical Sciences, says his findings could help to explain a rare form of the disease that causes sufferers to urinate more than three litres every day.

As reported in the journal Gene, Professor Elphick has discovered that some marine animals produce 'NG peptides' - proteins that help the creatures release their eggs and sperm at the same time. Critically, it emerges that NG peptides are made by a gene very similar to the mutant gene that causes diabetes insipidus.

He says: "Genetic tests on patients with diabetes insipidus show their symptoms are caused by an inability to produce the hormone vasopressin, which tells the body how much urine to make.

"I have discovered that marine animals, like sea urchins and acorn worms, produce NG peptides in much the same way to how our brain cells produce vasopressin. This similarity can be traced back to a one-off genetic accident in one of our ancient sea-dwelling ancestors, when a gene for vasopressin-like molecules mutated and became associated with a gene for NG peptides."

Asked about the medical relevance of his discovery, Professor Elphick said: "By researching further into how animals like sea urchins produce NG peptides, we will understand better why the faulty human vasopressin gene can cause this form of diabetes in around 10,000 people in the UK."


'/>"/>

Contact: Simon Levey
s.levey@qmul.ac.uk
44-207-822-5404
Queen Mary, University of London
Source:Eurekalert

Page: 1

Related biology news :

1. Snakes, salamanders and other creatures thrive in areas with higher deer populations
2. Predicting the distribution of creatures great and small
3. Sydney harbors deadly diet for sea creatures
4. Scientists find how amber becomes death trap for watery creatures
5. Duke technique is turning proteins into glass
6. Measuring protein movements with nanosecond resolution
7. Light activated warhead turns modest molecules into super protein killers
8. Behavior of single protein observed in unprecedented detail by Stanford chemists
9. Study shows potential for using algae to produce human therapeutic proteins
10. Biochemist researching computer models of protein structure that help high school, college students
11. Antifreeze proteins can stop ice melting, Queens professors find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... microbes that thrive in the deserts, rainforests, prairies and ... beneath New York City,s Central Park, according to a ... the University of Colorado Boulder. , The research ... Park,s 843 acres and discovered a stunning diversity of ... before. , Only 8.5 percent to 16.2 percent ...
(Date:9/30/2014)... EVANSTON, Ill. --- Do we think of nature as something ... something we need to "preserve?" Or do we think of ... a part of nature, but what about a house? ... They are also reflected in our actions, our speech and ... partnership with the University of Washington, the American Indian Center ...
(Date:9/30/2014)... The National Institutes of Health (NIH) awarded Lawrence ... develop an electrode array system that will enable ... through unprecedented resolution and scale. , LLNL,s grant-funded ... President Obama,s BRAIN (Brain Research through Advancing ... to revolutionize our understanding of the human mind ...
Breaking Biology News(10 mins):Microbes in Central Park soil: If they can make it there, they can make it anywhere 2Microbes in Central Park soil: If they can make it there, they can make it anywhere 3The cultural side of science communication 2NIH taps lab to develop sophisticated electrode array system to monitor brain act 2NIH taps lab to develop sophisticated electrode array system to monitor brain act 3
... HOUSTON (May 9, 2012) Like their human cousins, ... get it. If the menu,s right, giraffes are even less ... R. Brown School of Engineering have designed devices to efficiently, ... very different residents of the Houston Zoo. "For the ...
... LANSING, Mich. For his work on developing new ... been named a Grand Challenges Explorations winner, an initiative ... Robert Abramovitch of MSU,s Department of Microbiology ... glows green in response to conditions that mimic human ...
... Brigham and Women,s Hospital (BWH), the ingredient that gives ... the future of weight loss. Ali Tavakkoli, ... published a study investigating whether two surgeries called vagal ... pepper,s burning sensationand vagatomy can achieve weight loss and ...
Cached Biology News:Feeding without the frenzy 2Biosensor illuminates compounds to aid fight against TB 2Hot sauce ingredient reduces 'beer belly' fat as a weight-loss surgery alternative 2
(Date:9/30/2014)... German . , The ... a semiconductor layer. Quantum dots are small structures that spontaneously ... short laser pulse is fired at the photonic crystal, its ... change in the electromagnetic field around it. This change can ... the dot. As soon as the refractive index recovers its ...
(Date:9/30/2014)... Sept. 30, 2014 Pacific Northwest Biotechnology, ... Summary Global Markets Direct,s, ,Pacific Northwest Biotechnology, ... an overview of the Pacific Northwest Biotechnology, LLC,s ... provides comprehensive information on the current therapeutic developmental ... comparative analysis at various stages, therapeutics assessment by ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 Over the ... primarily due to rising R&D budgets and increased acceptance ... fast growing pharmaceutical and biotechnology industries are also catalyzing ... laboratory filtration market is expected to grow at a ... is estimated to be worth $2,532.6 million by 2019. ...
(Date:9/30/2014)... 30, 2014 CORD:USE Cord Blood Bank – ... it has entered into an Equity and Exclusive Services ... licensed a series of patented technologies for the isolation of ... applications.  Tianhe is performing Phase I/II clinical trials in ... using Tianhe,s Stem Cell Educator Therapy showing ...
Breaking Biology Technology:Ultrafast remote switching of light emission 2Pacific Northwest Biotechnology, LLC - Product Pipeline Review - 2014 2Pacific Northwest Biotechnology, LLC - Product Pipeline Review - 2014 3Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 2Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 3Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 4Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 5CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 2CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 3CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 4
... PathDetect reporting system for studying NFAT ... Mary Buchanan Chao-Feng Zheng ,Stratagene , ... reporter plasmid, is designed for studying the activation ... factors. These,interesting proteins, which play an essential role ...
... Taq DNA polymerase utilizes ultra-pure ,Taq2000 ... DNA polymerase ,features a modified version of ... start capability. Using SureStart Taq, hot start is ,in- corporated ... little or no modification of cycling parameters or reaction ,conditions. ...
... Up to 25-fold higher transformation efficiency of ligated ... Alan Greener ,Stratagene Cloning Systems, Inc. , ... improves the transformation efficiency of ligated DNA. Epicurian,Coli ... cells* yielded,transformation efficiencies for ligated DNA that were ...
Cached Biology Technology:Cis-Reporting System Monitors Intracellular Calcium Mobilization 2Cis-Reporting System Monitors Intracellular Calcium Mobilization 3Cis-Reporting System Monitors Intracellular Calcium Mobilization 4Cis-Reporting System Monitors Intracellular Calcium Mobilization 5Improve Amplification Specificity with Hot Start PCR Enzyme 2Improve Amplification Specificity with Hot Start PCR Enzyme 3New Competent Cells for Highest Transformation Efficiencies 2New Competent Cells for Highest Transformation Efficiencies 3New Competent Cells for Highest Transformation Efficiencies 4New Competent Cells for Highest Transformation Efficiencies 5New Competent Cells for Highest Transformation Efficiencies 6New Competent Cells for Highest Transformation Efficiencies 7New Competent Cells for Highest Transformation Efficiencies 8
... The DNA120 is a dedicated concentrator for ... precipitates of DNA/RNA. The integrated system combines ... pump. The compact design, automatic pump and ... run time; one for heater time), makes ...
... (For small quantities of solvents with DNA ... concentrator/centrifugal evaporator systems respond to specific applications ... and safe concentration of heat-labile samples. The ... different of cold traps and a wide ...
... The Jouan RC10 series of vacuum ... product protection features allied to rapid and ... modules can be combined with oil-free or ... traps and a wide selection of rotors ...
For relative and/or absolute quantification with standard accuracy requirements using MS or NMR instruments...
Biology Products: