Navigation Links
Scripps scientists develop test providing new pathway for identifying obesity, diabetes drugs
Date:9/16/2010

La Jolla, CA, September 15, 2010 Scientists at The Scripps Research Institute have designed a new molecular test that will allow researchers to look for potential drugs targeting a human metabolic enzyme believed to stimulate the appetite and play a role in diabetes.

The new test, which the scientists call a simple assay, will allow researchers to look through hundreds of thousands of compounds for those that have potential to block the action of an enzyme known as ghrelin O-acyltransferase (GOAT). If drugs can be found that safely suppress the action of GOAT, they may help people who have clinical problems with appetite, obesity, and diabetes.

"There hasn't been a simple screen until now," says Kim D. Janda, Ph.D., a professor in the Departments of Chemistry and Immunology and Microbial Science, member of The Skaggs Institute for Chemical Biology, and director of The Worm Institute for Research and Medicine at Scripps Research.

Janda and Amanda Garner, Ph.D., a research associate in his laboratory, describe the new approachwhich may also prove useful for investigating other enzymes involved in a variety of diseasesin an advance, online Early edition of the journal Angewandte Chemie on September 15, 2010.

A Tempting Target

Even though GOAT was only discovered recently, in 2008, scientists had speculated for years that it had to exist. After all, its target (ghrelin, or the "G" in the acronym GOAT) had been known for more than a decade.

Ghrelin, a small peptide hormone that is mainly produced in the stomach, signals hunger, typically before meals. Ghrelin has been associated with Prader-Willi syndrome a common genetic cause of childhood obesity in which patients have exceptionally high ghrelin levels.

The biology of ghrelin is quite intricate. For ghrelin to impact the body's metabolism, it must move from the stomach to the brain, where it acts on neurons. GOAT acts as a "passpor
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scripps research team wins $5.1 million to develop DNA sequencing technology
2. Team led by Scripps Research scientist identifies new gene for memory
3. Seafood stewardship questionable: UBC-Scripps experts
4. UCI-Scripps study links cellular motors to memory
5. Scripps Research scientists uncover new mechanism of memory formation
6. Scripps Oceanography biologists awarded prestigious honors
7. Scripps Research scientists uncover possible cocaine addiction trigger
8. Scripps research study opens the door to new class of drugs for epileptic seizures
9. Scripps research study shows infectious prions can arise spontaneously in normal brain tissue
10. Scripps Research scientists find new way to attack cancerous cells
11. Scripps research scientists determine structure of immune molecule that counteracts HIV strains
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/5/2015)... 2015 According to a new ... Software, Services, Vertical (BFSI, Airport, IT & Telecom, Utilities, ... Forecast to 2020", published by MarketsandMarkets, defines and segments ... various segments. The global PIAM Market is estimated to ... by 2019, at a CAGR of 14.9 % from ...
(Date:8/5/2015)... The biosensors market is proving highly attractive ... newer sectors, and development of devices resulting in higher ... seen the entry of multiple participants each year with ... (Photo - http://photos.prnewswire.com/prnh/20150805/255570 ) Recent ... Global Biosensors Market ( http://www.frost.com/nee9 ), finds that ...
(Date:8/4/2015)... Aug. 4, 2015  AMRI (NASDAQ: AMRI ) today reported ... 2015. Highlights: , Second quarter contract revenue ... 2014 , Adjusted contract margins of ... $0.22, including a $0.05 decrease in EPS from royalties in the ... million "We are very pleased to present another ...
Breaking Biology News(10 mins):Physical Identity and Access Management Market Worth $546.2 Million by 2019 2Physical Identity and Access Management Market Worth $546.2 Million by 2019 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 4Innovative Biosensors Incite Use in Non-Traditional Applications 2Innovative Biosensors Incite Use in Non-Traditional Applications 3Innovative Biosensors Incite Use in Non-Traditional Applications 4AMRI Announces Second Quarter 2015 Results 2AMRI Announces Second Quarter 2015 Results 3AMRI Announces Second Quarter 2015 Results 4AMRI Announces Second Quarter 2015 Results 5AMRI Announces Second Quarter 2015 Results 6AMRI Announces Second Quarter 2015 Results 7AMRI Announces Second Quarter 2015 Results 8AMRI Announces Second Quarter 2015 Results 9AMRI Announces Second Quarter 2015 Results 10AMRI Announces Second Quarter 2015 Results 11AMRI Announces Second Quarter 2015 Results 12AMRI Announces Second Quarter 2015 Results 13AMRI Announces Second Quarter 2015 Results 14AMRI Announces Second Quarter 2015 Results 15AMRI Announces Second Quarter 2015 Results 16AMRI Announces Second Quarter 2015 Results 17AMRI Announces Second Quarter 2015 Results 18AMRI Announces Second Quarter 2015 Results 19AMRI Announces Second Quarter 2015 Results 20AMRI Announces Second Quarter 2015 Results 21AMRI Announces Second Quarter 2015 Results 22AMRI Announces Second Quarter 2015 Results 23AMRI Announces Second Quarter 2015 Results 24
... at the University of Leeds are developing methods of ... organic chemicals such as vinegar. , The harmful ... waste from former textiles factories, smelters, and tanneries have ... to problems with the kidneys, liver, lungs and skin. ...
... 3, 2009) When it comes to solving complex ... engineer, looks to nature for solutions. Finding inspiration in ... helping to tackle one of society,s biggest challenges: improving ... the survival rate of cancer patients. Today, ...
... March 2, 2009 Two researchers at UT ... Research Fellows, an award intended to "support the work ... and often at pivotal stages in their work." ... for their work in chemistry. The Alfred P. Sloan ...
Cached Biology News:Cleansing toxic waste -- with vinegar 2MIT student develops new innovations to selectively kill cancer cells 2MIT student develops new innovations to selectively kill cancer cells 3MIT student develops new innovations to selectively kill cancer cells 4Two UT Southwestern researchers awarded Sloan fellowships 2
(Date:8/31/2015)... , Aug. 31, 2015 /PRNewswire/ - BIOREM Inc. (TSXV: ... totalling $5.7 million. The orders are for air emission abatement projects ... particular note is a large order for a municipality in ... will be replacing a competitor,s system that failed to meet ... our engineered solutions," said Derek S. Webb , President ...
(Date:8/31/2015)... DIEGO , Aug. 31, 2015 MabVax ... development company announces that the Company,s lead antibody, HuMab ... of five separate presentations during the upcoming World Molecular ... September 2-5, 2015. Researchers from the Department ... will present results on the use of MabVax,s lead ...
(Date:8/31/2015)... Research and Markets ( http://www.researchandmarkets.com/research/k6lcp2/mexico_biomedical ) has ... Market - Growth, Trends & Forecasts (2014-2020)" report ... Biomedical Sensors market is estimated at $0.20 billion by ... 2014-2020 The near future will bring biomedical ... each individual. These sensors can be set to trigger ...
(Date:8/31/2015)... Aug. 31, 2015 Research and Markets ( ... "Middle East & Africa Biomedical Sensors Market - Growth, ... The Middle East ... $0.84 billion by 2018 at a CAGR of 3.26% ... will bring Biomedical sensors that are adaptable to the ...
Breaking Biology Technology:MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 2MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 3MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 4Mexico Biomedical Sensors Market Report 2015-2020 2Middle East & Africa Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts to 2020 2
... first-cycle,approval for a new molecular entity (NME) is ... average, according to a new analysis from,PAREXEL Consulting, ... PRXL ),and leading global life sciences consultancy serving ... PAREXEL Consulting,analysis, 60 percent of sales for newly-approved ...
... Medical and Security Detection Applications, ST. LOUIS, ... SAFC(R), a member of the Sigma-Aldrich Group (Nasdaq: ... the scope of its electronic materials,offering with the ... http://www.safchitech.com/halides ). These new raw materials enable the,growth ...
... ... Nutrition and Disease Research, KANNAPOLIS, N.C. ... Research Institute (DHMRI), located at the North,Carolina Research Campus ... that Waters(R) has been selected as the institute,s,primary supplier ...
Cached Biology Technology:PAREXEL Consulting Quantifies Speed to Market: First-Cycle Approval for NME Produces $640 Million in Incremental Revenue on Average 2PAREXEL Consulting Quantifies Speed to Market: First-Cycle Approval for NME Produces $640 Million in Incremental Revenue on Average 3PAREXEL Consulting Quantifies Speed to Market: First-Cycle Approval for NME Produces $640 Million in Incremental Revenue on Average 4PAREXEL Consulting Quantifies Speed to Market: First-Cycle Approval for NME Produces $640 Million in Incremental Revenue on Average 5SAFC Hitech(TM) Expands Electronic Materials Portfolio With the Introduction of Scintillation Crystal Growth Halides 2SAFC Hitech(TM) Expands Electronic Materials Portfolio With the Introduction of Scintillation Crystal Growth Halides 3SAFC Hitech(TM) Expands Electronic Materials Portfolio With the Introduction of Scintillation Crystal Growth Halides 4David H. Murdock Research Institute Taps Waters for Laboratory Technology 2David H. Murdock Research Institute Taps Waters for Laboratory Technology 3
... separation and fractionation of nucleic-acid ... nuclei from cytosolic proteins A ... greatly facilitating study of low-abundance ... acid binding proteins (e.g., transcription ...
... was developed for culturing hybrid cells that ... consists of doubling the amino acids and ... concentrations have been altered as well. This ... liter, which may render it unsuitable for ...
... is an 18 amino acid synthetic peptide whose sequence corresponds to ... peptide is (amino to carboxy terminus): M(1) - A - S ... A - S - P - R - D - A ... peptide may be used for neutralization and control experiments with the ...
... EpiTect Bisulfite Kit enables complete conversion ... less than 6 hours. The highly ... against DNA degradation and a spin-column-based ... fast and reliable results for all ...
Biology Products: