Navigation Links
Scripps scientists develop first examples of RNA that replicates itself indefinitely
Date:1/9/2009

Now, a pair of Scripps Research Institute scientists has taken a significant step toward answering that question. The scientists have synthesized for the first time RNA enzymes that can replicate themselves without the help of any proteins or other cellular components, and the process proceeds indefinitely.

The work was published on Thursday, January 8, 2008, in Science Express, the advanced, online edition of the journal Science.

In the modern world, DNA carries the genetic sequence for advanced organisms, while RNA is dependent on DNA for performing its roles such as building proteins. But one prominent theory about the origins of life, called the RNA World model, postulates that because RNA can function as both a gene and an enzyme, RNA might have come before DNA and protein and acted as the ancestral molecule of life. However, the process of copying a genetic molecule, which is considered a basic qualification for life, appears to be exceedingly complex, involving many proteins and other cellular components.

For years, researchers have wondered whether there might be some simpler way to copy RNA, brought about by the RNA itself. Some tentative steps along this road had previously been taken by the Joyce lab and others, but no one could demonstrate that RNA replication could be self-propagating, that is, result in new copies of RNA that also could copy themselves.

In Vitro Evolution

A few years after Tracey Lincoln arrived at Scripps Research from Jamaica to pursue her Ph.D., she began exploring the RNA-only replication concept along with her advisor, Professor Gerald Joyce, M.D., Ph.D., who is also Dean of the Faculty at Scripps Research. Their work began with a method of forced adaptation known as in vitro evolution. The goal was to take one of the RNA enzymes already developed in the lab that could perform the basic chemistry of replication, and improve it to the point that it could drive efficie
'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Scripps Research scientists shed light on how DNA is unwound so that its code can be read
2. Dolphin population stunted by fishing activities, Scripps/NOAA study finds
3. Scripps research team defines new painkilling chemical pathway
4. Scripps research scientists identify blood component that turns bacteria virulent
5. Scripps research scientists identify compounds for stem-cell production from adult cells
6. Scripps Florida scientists awarded $1.5M to fight major water and food parasites
7. Scripps research team sheds light on immune system suppression
8. Scripps research team solves structure of beneficial virus
9. Oceans on the precipice: Scripps scientist warns of mass extinctions and rise of slime
10. Scripps scientists will assess Beijing Olympics air pollution control efforts
11. Scripps study sets high economic value on threatened Mexican mangroves
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... PA, July 10, 2014 Inflammatory diseases can ... patient, complicating treatment because a medication effective for ... example is the anti-arthritic medication dexamethasone, which alleviates ... A study in the August issue of ... effects of a new class of anti-arthritic drugs, ...
(Date:7/9/2014)... found in the bladders of healthy women differ ... of incontinence, according to researchers from Loyola University ... findings, published July 9, 2014, in the American ... suggest that bacterial communities may play a role ... (UUI) is a common, yet poorly understood, condition ...
(Date:7/9/2014)... ranges in which animals can be found, concern mounts ... an increased range for a host mean new territory ... a team of UC Santa Barbara scientists, including parasitologists ... in the Journal of Biogeography , Hechinger, Kuris ... may happen: Hosts may actually lose their parasites when ...
Breaking Biology News(10 mins):New class of anti-arthritis drugs effectively treats multiple inflammatory diseases 2Not at home on the range 2Not at home on the range 3Not at home on the range 4
... of Oceanography at UC San Diego have completed a ... Northwest Mexico and the results could have far-ranging implications ... area. The scientists, led by Scripps postdoctoral researcher ... the region that includes Baja California as well as ...
... the genome--the genetic code--of orangutans. This new tool may be ... captive and wild orangutans. The new map of the orangutan ... of the evolution of primates, including humans. Partially ... in the Jan. 27 issue of Nature . It ...
... Society of Plant Biologists (ASPB) community are among the 503 ... Advancement of Science (AAAS). These individuals will be recognized for ... to be held on February 19, 2011, during the AAAS ... a certificate and a blue and gold rosette as a ...
Cached Biology News:Study finds common ground for ecosystems and fishing in Northwest Mexico 2Scientists determine what makes an orangutan an orangutan 2Scientists determine what makes an orangutan an orangutan 328 ASPB members elected as AAAS Fellows 2
(Date:1/15/2014)... The Microcompetition with Foreign DNA theory explains ... these latent viruses is the Epstein Barr Virus (EBV), and ... (RA) is a chronic inflammatory disease that destroys the body’s ... RA patients have high concentrations of EBV DNA in their ...
(Date:1/15/2014)... 15, 2014 2013 was a banner ... State Technologies®. They saw continued independent research led by ... were awarded a $1 million grant from the Susanne ... and Behavior” a peer reviewed journal, Amy Grant highlighted ...
(Date:1/15/2014)... 2014 AudioNotch is the internet's leading ... the treatment of tinnitus. Patients listen to sound therapy ... a period of weeks to months, their tinnitus volume decreases. ... forms: Notched Music and Notched White Noise. Now, AudioNotch is ...
(Date:1/14/2014)... 2014 Date: Friday, April 11, 2014 , ... Club, 1360 Almshouse Road, Warrington, Pa. , Details: ... dedicated to finding a cure for hepatitis B and improving ... its annual Crystal Ball on Friday, April 11 at Warrington ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2
... - At least 45 girls in grades six ... Tech 2007, which will be held June 26 to ... ,The program, sponsored by area technology employers to encourage ... technology, will feature hands-on technical activities that introduce girls ...
... has been removed for Bruce Mass following his appointment ... Wisconsin-Milwaukee . , ,Rita Hartung Cheng, provost and vice ... national search. , ,Maas has undergraduate majors in accounting ... as campus budget manager, assistant dean for business affairs ...
... of Fresno in California's San Joaquin Valley is one of ... from grapes to livestock, from almonds to dairy products, and ... San Joaquin Valley these days is biofuel. , ,Like many ... recent visit are happy that demand for ethanol and biodiesel ...
Cached Biology Technology:Kind approach to leveraging biofuels 2Kind approach to leveraging biofuels 3
Molecular Biological Resources has extensive abilities cloning and expression of prokaryotic and eukaryotic proteins. Please contact lloconne@molbiores.com to discuss your project. Contact lloconne@...
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
quantitation of phosphatase activity, evaluation of hits and leads from HTS...
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Biology Products: