Navigation Links
Scripps scientist awarded $1.8 million to develop new approaches to lung cancer therapy

JUPITER, FL, January 30, 2014 Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded approximately $1.8 million from the National Cancer Institute of the National Institutes of Health to identify the signaling pathways that underlie lung cancer and to use this information to develop new therapeutic approaches.

Joseph Kissil, a TSRI associate professor, will be principal investigator of the new five-year grant, which extends a study that began in 2006.

Although death rates from lung cancer have fallen in the last 20 years, survival rates are still not good, largely because of a lack of effective treatments for advanced disease.

Kissil's research into non-small cell lung cancer, the most common form of the disease, has shown that a well-known cancer-causing gene implicated in a number of malignancies plays a far more critical role than previously thought. Activating mutations of the K-ras gene are found in more than a third of lung cancers.

"There are clear links between K-ras-induced lung cancer and the receptor known as Notch 1," Kissil said. "A loss of this receptor results in reduced tumor growth. The new grant will let us continue our research into Notch signaling pathways as potentially important therapeutic options for treatment of this disease."


Contact: Eric Sauter
Scripps Research Institute

Page: 1

Related biology news :

1. Scripps Florida scientists offer new insight into neuron changes brought about by aging
2. Scripps leads first global snapshot of key coral reef fishes
3. Scripps Research Institute scientists achieve most detailed picture ever of key part of hepatitis C
4. Scripps oceanography researchers engineer breakthrough for biofuel production
5. NIH awards Scripps Translational Science Institute $29 million grant
6. James Cameron to be publicly honored with Scripps Nierenberg Prize
7. Scripps Research announces research & license agreement with Janssen Pharmaceuticals
8. John Moores gives $2 million to Scripps Research to develop river blindness field test
9. Scripps Research and Takeda Pharmaceuticals announce expanded research collaboration
10. Vibrant mix of marine life found at extreme ocean depths, Scripps analysis reveals
11. Scripps Florida scientist awarded prestigious Javits Neuroscience Investigator Award
Post Your Comments:
Related Image:
Scripps scientist awarded $1.8 million to develop new approaches to lung cancer therapy
(Date:11/2/2015)... Calif. , Nov. 2, 2015  SRI International ... million to provide preclinical development services to the National ... contract, SRI will provide scientific expertise, modern testing and ... variety of preclinical pharmacology and toxicology studies to evaluate ... --> The PREVENT Cancer Drug Development Program ...
(Date:10/29/2015)... Oct. 29, 2015  The J. Craig Venter Institute ... "DNA Synthesis and Biosecurity: Lessons Learned and Options for ... Health and Human Services guidance for synthetic biology providers ... --> --> Synthetic ... the potential to pose unique biosecurity threats. It now ...
(Date:10/29/2015)... ARBOR, Mich. , Oct. 29, 2015 /PRNewswire/ ... Eurofins Genomics for U.S. distribution of its DNA ... DNA-seq kit and Rubicon,s new ThruPLEX Plasma-seq kit. ... to enable the preparation of NGS libraries for ... plasma for diagnostic and prognostic applications in cancer ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... IN (PRWEB) , ... November 24, 2015 , ... The ... newest Special Interest Group (SIG), MultiGP, also known as Multirotor Grand Prix, to represent ... the last few years. Many AMA members have embraced this type of racing and ...
(Date:11/24/2015)... 24, 2015 --> ... report released by Transparency Market Research, the global non-invasive ... CAGR of 17.5% during the period between 2014 and ... Global Industry Analysis, Size, Volume, Share, Growth, Trends and ... testing market to reach a valuation of US$2.38 bn ...
(Date:11/24/2015)... 24, 2015 /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ: ... the remaining 11,000 post-share consolidation (or 1,100,000 pre-share ... "Series B Warrants") subject to the previously disclosed ... 23, 2015, which will result in the issuance ... to the issuance of such shares, there will ...
(Date:11/24/2015)... ... November 24, 2015 , ... In harsh industrial processes, ... for in-line sensors can represent a weak spot where leaking process media is ... retractable sensor housings , which are designed to tolerate extreme process conditions. They ...
Breaking Biology Technology: