Navigation Links
Scripps research team solves structure of 'beneficial' virus
Date:10/8/2008

The 3-D structure of the virus, known as Seneca Valley Virus-001, reveals that it is unlike any other known member of the Picornaviridae viral family, and confirms its recent designation as a separate genus "Senecavirus." The new study reveals that the virus's outer protein shell looks like a craggy golf ballone with uneven divets and raised spikesand the RNA strand beneath it is arranged in a round mesh rather like a whiffleball.

"It is not at all like other known picornaviruses that we are familiar with, including poliovirus and rhinoviruses, which cause the common cold," says the study's senior author, Associate Professor Vijay S. Reddy, Ph.D., of The Scripps Research Institute. "This crystal structure will now help us understand how Senecavirus works, and how we can take advantage of it."

The Senecavirus is a "new" virus, discovered several years ago by Neotropix Inc., a biotech company in Malvern, Pennsylvania. It was at first thought to be a laboratory contaminant, but researchers found it was a pathogen, now believed to originate from cows or pigs. Further investigation found that the virus was harmless to normal human cells, but could infect certain solid tumors, such as small cell lung cancer, the most common form of lung cancer.

Scientists at Neotrophix say that, in laboratory and animal studies, the virus demonstrates cancer-killing specificity that is 10,000 times higher than that seen in traditional chemotherapeutics, with no overt toxicity. The company has developed the "oncolytic" virus as an anti-cancer agent and is already conducting early phase clinical trials in patients with lung cancer.

But the researchers still did not know how the virus worked, so they turned to Reddy. He and his Scripps Research team, especially Sangita Venkataraman, Ph.D., a postdoctoral researcher, determined the Senecavirus crystal structure.

Reddy describes the differences they found between other picornaviruses and the Senecavirus as like variations among car models of the same manufacturer. "The chassis is the same, but the body style is different," he says. "How the body of a virus is shaped determines how it infects cells."

The structure of the Senecavirus is also depicted at http://viperdb.scripps.edu/, the "Virus Particle Explorer" developed at Scripps Research by Reddy and his colleagues. The online database is a worldwide resource for information on the structure of viral particles; it contains details of 253 viruses to date.

Once the structure of Seneca Valley Virus-001 was solved, researchers went on to identify several areas on the viral protein coat that they think might hook onto receptors on cancer cells in the process of infecting them. The researchers are now conducting further investigations on this process. "It will be critically important to find out what region of its structure the virus is using to bind to tumor cells, and what those cancer cell receptors are," Reddy says. "Then we can, hopefully, improve Senecavirus enough to become a potent agent that can be used with many different cancers."


'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Related biology news :

1. Oceans on the precipice: Scripps scientist warns of mass extinctions and rise of slime
2. Scripps scientists will assess Beijing Olympics air pollution control efforts
3. Scripps study sets high economic value on threatened Mexican mangroves
4. Scripps research scientists reveal key structure from ebola virus
5. Scripps Research Institute awarded patent for remarkable chemical technology
6. Scripps Oceanography Research pegs ID of red tide killer
7. Fishing throws targeted species off balance, Scripps study shows
8. Bright lights: Mystery of glowing antibody solved by Scripps research scientists
9. Scripps expedition provides new baseline for coral reef conservation
10. Scripps Research discovery leads to broad potential applications in CovX-Pfizer deal
11. Scripps scientists develop new tests that identify lethal prion strains quickly and accurately
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... 2017 Research and Markets has announced the ... to their offering. ... eye tracking market to grow at a CAGR of 30.37% during ... Market 2017-2021, has been prepared based on an in-depth market analysis ... and its growth prospects over the coming years. The report also ...
(Date:4/5/2017)... YORK , April 5, 2017 Today ... is announcing that the server component of the HYPR ... known for providing the end-to-end security architecture that empowers ... HYPR has already secured over 15 million ... makers including manufacturers of connected home product suites and ...
(Date:3/30/2017)... , March 30, 2017 The research ... system for three-dimensional (3D) fingerprint identification by adopting ground breaking 3D ... a new realm of speed and accuracy for use in identification, ... an affordable cost. ... ...
Breaking Biology News(10 mins):
(Date:6/26/2017)... ... , ... The Workgroup for Electronic Data Interchange (WEDI) , the nation’s ... information exchange and a statutory advisor to the U.S. Department of Health and Human ... the National Coordinator for Health Information Technology, will deliver the keynote at its 2017 ...
(Date:6/23/2017)... ... June 23, 2017 , ... RURO, Inc., a leading LIMS, ... its rapidly growing Laboratory Information System. , LimitLIS® version 3 is includes new ... provide more customization options. Each of these has been “under the microscope” in ...
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... ... for model aircraft flying hobbyists, and the University Aviation Association (UAA), the unifying ... students. The UAS4STEM Collegiate Challenge will encourage teamwork, competition, and success through a ...
(Date:6/22/2017)... ... ... Building on the success of the inaugural RAADfest last year, RAADfest 2017 ... in radical life extension. RAADfest combines cutting edge science presented for a lay audience, ... making it the largest most comprehensive and inclusive super longevity event in the world. ...
Breaking Biology Technology: