Navigation Links
Scripps research team defines new painkilling chemical pathway
Date:11/23/2008

al compounds against many members of enzyme families, in hope of finding effective and selective inhibitors.

For this project, the group developed about 200 compounds and found that one was a highly effective block for MAGL. The scientists dubbed the compound JZL184, named after Long's initials and the order in the series of potential inhibitors tested. JZL184 effectively blocks only MAGL among more than 40 related brain enzymes, which opened the door for the first definitive study of 2-AG's activity.

A New View of 2-AG

Unlike increased AEA, which causes only reduced pain sensation, the team found that MAGL inhibition using JZL184, and the resulting increase in 2-AG concentration, not only reduced pain in mice, but also induced other effects associated with the cannabinoid receptors, namely hypothermia and decreased movement.

"This really does suggest a sort of segregation of labor, if you will," says Cravatt of the differential effects of elevating AEA versus 2-AG as part of the overall function of the cannabinoid system. "That, I think, is a truly unique result."

While treatments based on inhibiting FAAH show great promise for controlling pain, manipulating MAGL levels could also be a boon for treatment development, especially if 2-AG's other effects, such as hypothermia, can be managed.

"There are so many different types of pain," Cravatt says, "that it's possible some types could be more effectively treated with one treatment than another."


'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. Scripps research scientists identify blood component that turns bacteria virulent
2. Scripps research scientists identify compounds for stem-cell production from adult cells
3. Scripps Florida scientists awarded $1.5M to fight major water and food parasites
4. Scripps research team sheds light on immune system suppression
5. Scripps research team solves structure of beneficial virus
6. Oceans on the precipice: Scripps scientist warns of mass extinctions and rise of slime
7. Scripps scientists will assess Beijing Olympics air pollution control efforts
8. Scripps study sets high economic value on threatened Mexican mangroves
9. Scripps research scientists reveal key structure from ebola virus
10. Scripps Research Institute awarded patent for remarkable chemical technology
11. Scripps Oceanography Research pegs ID of red tide killer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2009)... for premium fruit increases, growers are being challenged ... to boost their bottom line, orchard owners are ... quality while reducing labor costs. , Hand thinning, ... larger, healthier fruit, is among the most labor-intensive ... fruit production overhead, and, ultimately, prices paid by ...
(Date:12/11/2009)... does a cell manage to identify and degrade the ... body against serious diseases? The researchers Sabine C. Horn, ... Jarosch of the Max Delbrck Center for Molecular Medicine ... in this puzzle. In an enzyme complex that plays ... they discovered a scaffold regulating the identification and disposal ...
(Date:12/11/2009)... the deep ocean,s temperature variability and circulation system could ... deep ocean is affected more by surface warming than ... predictions of factors such as sea level rise and ... also been found to result in a more vigorous ... faster transport of large quantities of warm water, with ...
Breaking Biology News(10 mins):Horizontal string trimmer reduces labor costs, increases peach size 2MDC researchers identify a scaffold regulating protein disposal 2New discoveries could improve climate projections 2Brandeis studies evaluate visionary approach to improving eyesight 62470 1Brandeis studies evaluate visionary approach to improving eyesight 62470 2Recalls food worries spark booming business in food safety 10964 1From A to B and Everything In between 3B AB First Aid Launch New Web Storefront 62465 1From A to B and Everything In between 3B AB First Aid Launch New Web Storefront 62465 2From A to B and Everything In between 3B AB First Aid Launch New Web Storefront 62465 3
... in diameter is a road-closed sign: You can't squeeze ... say scientists at the University of Illinois at Urbana-Champaign. ... proteins that form trans-membrane channels in cell walls in ... between the cell and its environment. A subfamily of ...
... volume says Dutch researcher Bas Tomassen. He investigated the uptake ... and human cells. , Cell volume is the outcome ... the cell plasma membrane. A cell can regulate its volume ... Exactly how this process works is still not known. Bas ...
... Hopkins who has spent nearly three decades studying the ... warns that the first widespread outbreak of the bacterial ... of how humans can inadvertently help spread infectious organisms ... be published in The New England Journal of Medicine, ...
Other Biology News:Cells direct membrane traffic by channel width 2Water management in cells 2Infectious disease expert warns of spread of Rocky Mountain spotted fever 2Infectious disease expert warns of spread of Rocky Mountain spotted fever 3
(Date:12/15/2009)... The International Society for Medical Publication ... is continuing to accept abstracts for its 6th ... VA, April 19-21, 2010. This marks the first ... join the organization to submit an abstract to ... 12 AM EST, January 15, 2010. For submission ...
(Date:12/15/2009)... On January 20th, 2010, the inaugural European meeting ... (ISMPP) will be held at the Royal College ... attendees are expected at this prestigious event, providing ... medical writers and medical agencies to discuss the ... of guidelines and regulations such as GPP-2, FDAAA ...
(Date:12/15/2009)... MONT-SAINT-GUIBERT, Belgium, December 15 , ... Study Designed to Evaluate the Ability of,Cardiopoietic Cells ... Cardio3 BioSciences, a leading Belgian biotechnology company ... diseases,announced today that it has completed, two months ... its pivotal Phase II/III trial of C-Cure, a,unique ...
(Date:12/14/2009)... THOUSAND OAKS, Calif., Dec. 14 Array ... Inc.(Nasdaq: AMGN ) today announced that they ... rights to Array,s small-molecule glucokinase activator program, including ... clinical trial in patients with Type 2 diabetes. ... agreement, Array will receive an upfront payment of ...
Breaking Biology Technology:The International Society for Medical Publication Professionals Announces Call for Abstracts for Its 6th Annual Meeting 2The International Society for Medical Publication Professionals Announces Call for Abstracts for Its 6th Annual Meeting 3Announcing ISMPP EU 2010 - the First European Meeting of the International Society for Medical Publication Professionals, Royal College of Physicians, London, UK, January 20, 2010 2Cardio3 BioSciences Completes Patient Enrolment in First Stage of Pivotal Trial of C-Cure(R) in Heart Failure 2Cardio3 BioSciences Completes Patient Enrolment in First Stage of Pivotal Trial of C-Cure(R) in Heart Failure 3Array BioPharma and Amgen Partner in Type 2 Diabetes 2Array BioPharma and Amgen Partner in Type 2 Diabetes 3Array BioPharma and Amgen Partner in Type 2 Diabetes 4Array BioPharma and Amgen Partner in Type 2 Diabetes 5Array BioPharma and Amgen Partner in Type 2 Diabetes 6Array BioPharma and Amgen Partner in Type 2 Diabetes 7
... DEERFIELD, Ill., April 13 Baxter International (NYSE: ... its first quarter 2009 financial results on Thursday, April 16, ... To access the call, please dial 866-238-0637 (domestic) or ... ten minutes prior to the start of the call for ...
... the syndicated "Washington Watch" column, strongly criticized the proposed Patent ... failed legislation is not the best way to protect American ... ... Suffern, N.Y., (PRWEB) - General Patent Corporation chairman and CEO ...
... Device Company Doubles Manufacturing Capacity; Expands Global Reach ... April 13 Alpine Biomed Corporation, a global ... it has doubled its manufacturing capacity and expanded ... in Vietnam. The company will produce and distribute ...
Other Biology Technology:General Patent Corporation Calls New Patent Reform Bill Harmful to Inventors and Entrepreneurs 2Alpine Biomed Opens New Manufacturing Facility to Support Demand for Specialty Diagnostic Devices 2Alpine Biomed Opens New Manufacturing Facility to Support Demand for Specialty Diagnostic Devices 3
Mouse P-Selectin/CD62P MAb (Clone 127933)...
Molecular Biological Resources has extensive abilities cloning and expression of prokaryotic and eukaryotic proteins. Please contact lloconne@molbiores.com to discuss your project. Contact lloconne@...
IgD Chain C (AMS 9.1)...
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Biology Products: