Navigation Links
Scripps research study shows infectious prions can arise spontaneously in normal brain tissue
Date:7/26/2010

rion protein (PrPC). Following prion infection, the abnormal or misfolded prion protein (PrPSc) converts PrPC into a likeness of itself, by causing it to change its conformation or shape. The end-stage consists of large aggregates of these misfolded proteins, which cause massive tissue and cell damage.

A Highly Sensitive Test

In the new study, the scientists used the Scrapie Cell Assay, a test originally created by Weissmann that is highly sensitive to minute quantities of prions.

Using the Scrapie Cell Assay to measure infectivity of prion-coated wires, the team observed several unexpected instances of infectious prions in control groups where metal wires had been exposed only to uninfected normal mouse brain tissue. In the current study, this phenomenon was investigated in rigorous and exhaustive control experiments specifically designed to exclude prion contamination. Weissmann and his colleagues in London found that when normal prion protein is coated onto steel wires and brought into contact with cultured cells, a small but significant proportion of the coated wires cause prion infection of the cells and when transferred to mice, they continue to spawn the disease.

Weissmann noted that an alternative interpretation of the results is that infectious prions are naturally present in the brain at levels not detectable by conventional methods, and are normally destroyed at the same rate they are created. If that is the case, he noted, metal surfaces could be acting to concentrate the infectious prions to the extent that they became quantifiable by the team's testing methods.


'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scripps Research scientists find new way to attack cancerous cells
2. Scripps research scientists determine structure of immune molecule that counteracts HIV strains
3. Scripps Research scientists break barrier to creating potential therapeutic molecules
4. Team led by Scripps Research scientists discovers bodys own molecular protection against arthritis
5. American Society for Microbiology to honor Scripps, Claude ZoBell
6. Scripps Research study overturns decade-old findings in neurobiology
7. Scripps research scientists shed light on potential treatment for Gauchers disease
8. Scripps Research team provides groundbreaking new understanding of stem cells
9. New Scripps Research and GNF study helps explain how we can sense temperatures
10. Scripps Research scientists reveal how genetic mutations may cause type 1 diabetes
11. New nano-tool synthesized at Scripps Research Institute
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/4/2015)... Research and ... addition of the "Digital Forensics Market ... (Computer Forensics, Network Forensics, Mobile Device Forensics, ... and Region - Global Forecast to 2020" ... By Component (Hardware, Software, and Service), Sub-Segment ...
(Date:7/31/2015)... , Kina, 31. juli 2015 Den 10. ... afholdt af BGI fra den 22. - 25. oktober i ... Konferencen fejrer sin 10-års fødselsdag i år. Siden starten ... indflydelsesrige årlige møder på ,omik,-feltet, og er en af ... ICG-10 fokuserer på nylige gennembrud og fremskridt ...
(Date:7/31/2015)... , Chine, 31 juillet 2015 ... www.icg-10.org ) sera organisée par le BGI ... Shenzhen en Chine. ... Depuis son inauguration en 2006, l,ICG est devenue ... dans le domaine des « omiques » et c,est aussi ...
Breaking Biology News(10 mins):Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2Den 10. internationale konference om Genomics (ICG-10) åbner i oktober 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 3
... bacteria which prevent the body from successfully fighting off the ... in new research published today. , The study found ... work together to hamper the body's efforts to fight off ... bacteria's DNA by the body's white blood cells, which are ...
... new survey by researchers at Oregon State University and ... rivers and streams in the western United States found ... the more than 2,700 fish analyzed in the study ... the element throughout 12 western states caught the researchers ...
... University of Illinois at Champaign-Urbana have found that people ... in western Uganda are exchanging gastrointestinal bacteria ?specifically Escherichia ... E. coli strains migrating to chimps are resistant to ... study will appear in the April 2007 issue of ...
Cached Biology News:Scientists identify specific enzymes that make meningitis hard to fight 2Study finds mercury prevalent in many western fish 2Study finds mercury prevalent in many western fish 3E. coli bacteria migrating between humans, chimps in Ugandan park 2E. coli bacteria migrating between humans, chimps in Ugandan park 3
(Date:8/28/2015)... ... August 28, 2015 , ... Riordan-McKenna ... McKenna, DO, announced today that the use of sterile, dehydrated amniotic tissue AlphaPATCH™ ... of an otherwise non-healing surgical knee wound. , The case involved a 78-year-old ...
(Date:8/27/2015)... Poway, CA (PRWEB) , ... August 27, 2015 ... ... a unique opportunity for venture capital funds, investment firms and animal health companies ... the Forum have raised $160 million. Several have also received licensing agreements or ...
(Date:8/27/2015)...  Neogen Corporation (NASDAQ: NEOG ) announced today ... United Kingdom -based Lab M Holdings, a developer, ... systems. Lab M was founded in ... microbial testing and diagnostic products for the global food, ... sells into more than 70 countries worldwide, and has ...
(Date:8/27/2015)... , Aug. 27, 2015 The ... a patient,s eyes—and life—were saved by doctors at Vanderbilt ... working with NNFF, NovaBay Pharmaceuticals and Dr. John ... Center at Seton Medical Center in ... treatment used a breakthrough approach, pioneered by Dr. Crew, ...
Breaking Biology Technology:Dallas-Fort Worth Stem Cell Researchers Use Amniotic Tissue To Successfully Treat Non-Healing Surgical Wound 2Dallas-Fort Worth Stem Cell Researchers Use Amniotic Tissue To Successfully Treat Non-Healing Surgical Wound 3Dallas-Fort Worth Stem Cell Researchers Use Amniotic Tissue To Successfully Treat Non-Healing Surgical Wound 4VetStem Biopharma, Inc. Among Seventeen Companies Selected to Present at the KC Animal Health Investment Forum on September 1st 2015 2VetStem Biopharma, Inc. Among Seventeen Companies Selected to Present at the KC Animal Health Investment Forum on September 1st 2015 3Neogen acquires U.K.-based Lab M Holdings 2Patient's Life and Eyes Saved from Gruesome Flesh-Eating Infection Consuming Her Face 2Patient's Life and Eyes Saved from Gruesome Flesh-Eating Infection Consuming Her Face 3
... , COLUMBIA, S.C. , Jan. 19 ... the University of South Carolina,s Jones Physical Science ... scientific experiments. , The 33,000-square-foot project included the renovation of ... Cancer Research, which was established in 2002 by the Center ...
... , LEXINGTON, Ky. , Jan. 19 ... that it will be changing its name to VHGI Holdings, ... healthcare. According to Jim Renfro , VHGI President, "This ... to demonstrate our company,s commitment on asset diversification and creating ...
... , , , BANGALORE, India ... by Their Side, This Case Challenged Medical Excellence , ... Wockhardt Hospitals, Bangalore (Now a Network Hospital of Fortis),has performed a ... Brendan was suffering from congenital heart defect called - Tetralogy of,Fallot or ...
Cached Biology Technology:Hendrick Construction Renovates USC Science Building 2VirtualHealth Technologies Will Change Its Name to VHGI Holdings, Inc. and Surges Forward Into Broader Market 2VirtualHealth Technologies Will Change Its Name to VHGI Holdings, Inc. and Surges Forward Into Broader Market 32-Year-old Baby With Complex Heart Deformity Undergoes Major Open Heart Surgery at Wockhardt Hospitals, Bangalore - (now a Network Hospital of Fortis) Without any Blood Transfusion 22-Year-old Baby With Complex Heart Deformity Undergoes Major Open Heart Surgery at Wockhardt Hospitals, Bangalore - (now a Network Hospital of Fortis) Without any Blood Transfusion 3
... Cell Lines ,High Quality, Functionally-Validated, Ion Channel ... known for having a critical role in ... a key function in pain, CNS and ... have been investigated in therapeutic areas, such ...
Mouse monoclonal antibody raised against a partial recombinant TTC3. NCBI Entrez Gene ID = TTC3...
Mouse monoclonal antibody raised against a partial recombinant DENR. NCBI Entrez Gene ID = DENR...
Mouse monoclonal antibody raised against a partial recombinant CRKRS. NCBI Entrez Gene ID = CRKRS...
Biology Products: