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Scripps research scientists identify compounds for stem-cell production from adult cells
Date:11/5/2008

to transduced general cells treated with BIX alone. In vitro and in vivo characterizations confirmed that transduction of only two factors with simultaneous treatment with small molecules BIX and BayK was sufficient to reprogram general cells to become pluripotent stem cells.

The fact that BayK doesn't act on its own, but needs the presence of BIX to exert its effect suggests that cells that are already undergoing a form of reprogramming, perhaps caused by injury, might be more susceptible to it.

"Needless to say, more work needs to be done to understand the precise mechanism by which BayK affects the reprogramming process," Ding said. "It's interesting to find that a small molecule, which acts on signaling pathways that have not been linked to pluripotency and reprogramming previously can significantly enhance reprogramming efficiency. So far, it's the first small molecule of its type to show such an effect. This might allow us to ultimately reprogram the target cell in a more specific manner, without impacting healthy cells systemically in an in vivo setting."


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Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

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