Scripps research scientists identify blood component that turns bacteri...(ting bicarbonate. As a group ABC-transpo...)

Date:11/21/2008

ting bicarbonate. As a group, ABC-transporters use the energy of ATP hydrolysis to transport various substrates across cellular membranes. In this case, when the genes that code for the BAS2714-12 ABC transporter were deleted, the rate of bicarbonate uptake inside the cell greatly decreased, induction of toxin gene expression did not occur, and virulence in an animal model of infection was abolished. Elimination of carbon dioxide production within the bacterial cell had no effect on toxin production, suggesting that CO2 activity is not essential to virulence factor induction and that bicarbonate, not CO2, is the signal essential for virulence induction.

"In light of these findings, investigation of bicarbonate regulation and transport should be of much greater significance to a large number of pathogenic organisms," Perego said.

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Contact: Keith Mckeown kmckeown@scripps.edu 858-784-8134 Scripps Research Institute Source:Eurekalert

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