Navigation Links
Scripps research scientists identify blood component that turns bacteria virulent
Date:11/21/2008

bicarbonate transporter pathway may be investigated as a potential new target for drug intervention.

"How a bacterium recognizes signals in the host that trigger pathogenesis mechanisms, and the nature of the mechanisms necessary to develop pathogenesis, remain poorly understood," said Scripps Research Associate Professor Marta Perego, Ph.D., who conducted the study with Scripps Research postdoctoral fellow Adam Wilson, Ph.D., and colleagues. "We have identified an essential component for the induction of virulence gene expression in response to host bicarbonate levels and have used this finding to learn more about the extracellular and intracellular signals controlling virulence."

Theory Confirmed

Perego's latest discovery builds on her lab's expertise in the study of bacterial virulence signaling and in the regulatory networks responsible for pathogenicity in other gram-positive bacteria. Her interest in bicarbonate transport pathways as bacteria virulence signaling mechanisms grew out of an early observation that growth of B. anthracis in carbon dioxide and sodium bicarbonate strongly induced toxin production in the laboratory setting. The mechanism behind this observation, however, was never uncovered.

"It was observed that the best medium for toxin production was one that people believed mimicked conditions found in the blood of a human or animal host, where anthrax bacteria would find both carbon dioxide and bicarbonate. But we've never known which of these two molecules was the more important for bacterial pathogenesis, and whether this belief was correct," Perego said. "Now, we know that it is bicarbonate and that the growth in the presence of bicarbonate really mimics the host growth conditions."

In their current study, the Perego lab identified a previously unknown ATP-binding cassette transporter (ABC-transporter)which is identified by the gene number BAS2714-12that was shown to be essential to transpor
'/>"/>

Contact: Keith Mckeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scripps research scientists identify compounds for stem-cell production from adult cells
2. Scripps Florida scientists awarded $1.5M to fight major water and food parasites
3. Scripps research team sheds light on immune system suppression
4. Scripps research team solves structure of beneficial virus
5. Oceans on the precipice: Scripps scientist warns of mass extinctions and rise of slime
6. Scripps scientists will assess Beijing Olympics air pollution control efforts
7. Scripps study sets high economic value on threatened Mexican mangroves
8. Scripps research scientists reveal key structure from ebola virus
9. Scripps Research Institute awarded patent for remarkable chemical technology
10. Scripps Oceanography Research pegs ID of red tide killer
11. Fishing throws targeted species off balance, Scripps study shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... -- Aware, Inc. (NASDAQ: AWRE ), a leading ... June 26, 2014 that its Board of Directors had ... or approximately $40 million in total.  The Board established ... payment date of July 24, 2014.  The Company was ... ex-dividend date for this special cash dividend.  An ex-dividend ...
(Date:7/10/2014)... BELL, Pa. , July 2, 2014  Unisys Corporation,s ... Netherlands , Unisys Nederland N.V., today announced that it ... to deliver, implement and manage a new Basic Provision Biometrics ... Unisys won the contract with a solution ... identity management software. The term of the contract is up ...
(Date:7/10/2014)... , July 2, 2014 NXT-ID, Inc., (OTCQB: NXTD) a ... that CEO Mr. Gino Pereira was interviewed on ... in Tampa Florida . Mr. Pereira discusses ... Cedric Harris and how the Wocket™ aims to ... Cedric Harris tells Gino he ...
Breaking Biology News(10 mins):NASDAQ Sets Ex-Dividend Date for Aware, Inc.'s Special Cash Dividend of $1.75 Per Share 2Unisys Delivers New Basic Provision Biometrics Solution to Dutch Custodial Institutions Service 2Unisys Delivers New Basic Provision Biometrics Solution to Dutch Custodial Institutions Service 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 2Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 4
... to improve the nutritional quality of leafy green ... technology that features high-density photosynthetic photon flux generated ... be applied in greenhouses for preharvest treatment of ... harmful nitrates while allowing some beneficial nutrient levels ...
... are very fragile and highly susceptible to ... in ways to increase profits and reduce ... temperature management techniques. Collaborative research from scientists ... the University of Florida contains several findings ...
... Two scientific teams at Cincinnati Children,s Hospital Medical Center ... funding from the National Institutes of Health (NIH) to ... bone marrow failure. A team led by Yi ... five-year grant totaling $1.04 million from NIH,s National Cancer ...
Cached Biology News:Solid-state illuminator reduces nitrates in leafy green vegetables 2Hydrocooling shows promise for reducing strawberry weight loss, bruising 2$2.3 million in NIH funding for promising cancer research at Cincinnati Children's 2
(Date:7/10/2014)... (PRWEB) July 10, 2014 Unraveling life’s ... together. The Archer Family purchased a DNA ... DNA, but ended up with a lifetime of memories, ... within the family members’ DNA genuinely brought the family ... to search deeper into genetic history and prior to ...
(Date:7/10/2014)... 10, 2014 Senior supply chain management ... associations, addressed the challenges of “Reducing Cost, Lead Time, ... through strategic sourcing. Describing the partnership of the Bio ... Chain Management Institute ( SCMI) of the University ... 24 at the Kroc Institute of Peace and Justice ...
(Date:7/10/2014)... 2014 /PRNewswire-iReach/ -- Tute Genomics, the leader ... an agreement with Lineagen, Inc., to provide ... Dx PLUS.  Lineagen, focused on the ... currently offers FirstStep Dx PLUS, a ... by healthcare providers as a first-line genetic ...
(Date:7/10/2014)... University of Adelaide research may help in the fight ... can detect tiny quantities of explosives with the use ... the journal Sensors and Actuators B: Chemical , ... can detect explosives in concentrations as low as 6.3 ... of only a few minutes. , "Traditionally explosives detection ...
Breaking Biology Technology:Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Detecting trace amounts of explosives with light 2
... viruses or running out of space in your e-mail ... work with e-mail, with a bit more security and, ... whole gigabyte of it. Original air date: Saturday, March ... Read more about Thunderbird ...
... where ,methane and steam meet to begin the reforming process. ... reactor. Both photos courtesy of Modine Manufacturing Co. ... have presented a paper at the National Hydrogen Association conference ... to extract hydrogen from natural gas. , ,Modine, a firm ...
... technology and venture funding experts will share some tips ... EInnovate at the Marriott West in Waukesha. ... and technologists with a focus on building businesses and ... partner in a Californian seed and early-stage technology fund, ...
Cached Biology Technology:Modine Manufacturing makes hydrogen generator with ChevronTexaco 2Modine Manufacturing makes hydrogen generator with ChevronTexaco 3Modine Manufacturing makes hydrogen generator with ChevronTexaco 4
...
For mRNA Differential Display with three one-base anchored oligo-dT primers and rationally designed arbitrary 13mers. These kits feature the latest generation of isotopic mRNA Differential Display t...
NATIVE, ENZYME PORCINE TRYPSIN...
G-Protein Coupled Receptor Assay, For 500 assays. SPA. Category: Drug Screening & Cellular Assays, Assays ....
Biology Products: