Navigation Links
Scripps research scientists determine structure of immune molecule that counteracts HIV strains
Date:6/1/2010

and kill the virus.

Most of the antibodies that the body produces to fight HIV, however, are ineffective. The surface of the virus is cloaked with sugar molecules that prevent antibodies from slipping in and blocking the proteins the virus uses to latch onto a cell and infect it. To make matters more complicated, HIV is constantly mutating, so there are multiple HIV strains that antibodies elicited in any vaccine must be able to sense and destroy.

Nonetheless, while rare, broadly neutralizing antibodies against HIV do exist.

Last year, a team of scientists from IAVI, Scripps Research, Theraclone Sciences, and Monogram Biosciences published research from a systematic search for such antibodies among 2,000 volunteers. The study revealed two powerful new broadly neutralizing antibodies against HIVPG9 and PG16, isolated from a volunteer in Africa.

"Hammerhead" Structure

Once the broadly neutralizing antibodies were discovered, the next challenge was to figure out how they worked. To shed light on this question, in the current study members of the Wilson lab turned to x-ray crystallography, a technique that can solve structures to exquisitely high resolution.

In x-ray crystallography, scientists manipulate a protein or some other molecule so that a crystal forms. This crystal is then placed in front of a beam of x-rays, which diffract when they strike the atoms in the crystal. Based on the pattern of diffraction, scientists can reconstruct the shape of the original molecule. The scientists succeeded in forming crystals of the active part of the PG16 antibody, and in reconstructing the structure from the datawith some surprising results.

"The antibody has a novel and really interesting subdomain that hasn't been seen before," said Research Associate Rob Pejchal, who is first author of the paper. "This subdomain, which we found plays a major role in the recognition and neutralization of HIV, has a dif
'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Scripps Research scientists break barrier to creating potential therapeutic molecules
2. Team led by Scripps Research scientists discovers bodys own molecular protection against arthritis
3. American Society for Microbiology to honor Scripps, Claude ZoBell
4. Scripps Research study overturns decade-old findings in neurobiology
5. Scripps research scientists shed light on potential treatment for Gauchers disease
6. Scripps Research team provides groundbreaking new understanding of stem cells
7. New Scripps Research and GNF study helps explain how we can sense temperatures
8. Scripps Research scientists reveal how genetic mutations may cause type 1 diabetes
9. New nano-tool synthesized at Scripps Research Institute
10. Scripps Research scientists solve mystery of fragile stem cells
11. Scripps research team reveals how an old drug could have a new use for treating river blindness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2015)... , June 25, 2015  Imagine a tool specifically ... a healthier, happier life. That,s exactly what USANA,s ... do. The cutting-edge, portable health program provides a personalized ... to help improve your lifestyle and nutrition. ... and gala Wednesday night, USANA,s THA was honored with ...
(Date:6/24/2015)... 2015 This report provides market analysis of ... years. It contains an analysis of the drivers, challenges, ... impact from the short, medium, and long term perspective ... market, and technology trends that currently, prevail in the ... authorities to efficiently manage the increasing marine traffic and ...
(Date:6/24/2015)... , June 24, 2015 Biometry authentication ... emerging biometric password solution one face in. ... one face in, entering the expanding ... and affordable multifactor-authentication biometric answer to the password ... provided in partnership with KeyLemon, one face in ...
Breaking Biology News(10 mins):@USANAinc's Personalized Nutrition Program Wins Industry Innovation Award 2Automatic Identification System Market by Class, by Platform, by Application and by Geography - Global Forecasts & Analysis to 2014 - 2020 2KeyLemon Announces Partnership With Biometric Password Solution onefacein 2
... scientists, including Dr Paul Brotherton from the University of ... farmers into Europe had a major impact on the ... Communications , investigates a major component of the maternal ... H mitochondrial genomes from ancient human remains. This genetic ...
... the University of Pittsburgh School of Medicine shows that ... oxidative stress and gene activation patterns akin to disorders ... were recently reported in the online version of the ... (TBI) has become an important issue in combat casualty ...
... International Liver CongressTM 2013 has demonstrated the, accuracy of ... Non Alcoholic Fatty Liver disease (NAFLD) comprises two ... relatively benign and one group with NASH which may ... the only means of distinguishing the two was to ...
Cached Biology News:
(Date:7/1/2015)... ... July 01, 2015 , ... Apex Therapeutics announced today that company ... Philadelphia, PA. , The presentation took place on Tuesday, June 16 and ... the development of APX3330 for the treatment of pancreatic cancer. A copy of ...
(Date:6/30/2015)... July 1, 2015 R-Japan Co.,Ltd. obtained the license ... of Regenerative Medicine from the Ministry of Health, Labour and ... 2015. The fact that R- Japan ... the auditing from Pharmaceuticals and Medical Devices Agency (PMDA) on ... it to provide stem cell manufacturing service to medical institutions. ...
(Date:6/30/2015)... ... June 30, 2015 , ... Park Systems , ... scientific research into new classes of Nanoscale Graphene-based materials poised to revolutionize industries ... wonder material of the 21st Century' by the researchers who were awarded the ...
(Date:6/30/2015)... YORK , June 30, 2015  Today, Americord Registry, ... U.S., announced Andrew Horne , a partner at Kirkland ... Board. Logo - http://photos.prnewswire.com/prnh/20150630/226958LOGO   ... to Americord,s Advisory Board," says Martin Smithmyer , CEO ... in his legal career that will assist Americord,s growth and ...
Breaking Biology Technology:Apex Therapeutics Presented Company Overview at This Year’s BIO International Convention in Philadelphia, PA 2R-Japan Obtained Autologous Stem Cell Manufacturing License from the Ministry of Health, Labour and Welfare 2How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 2How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 3How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 4Americord Registry Announces Andrew Horne as Advisory Board Member 2
... and VIENNA, Oct. 27 eBioscience Corporation today ... technology pioneer Bender MedSystems GmbH in an all ... over 1,000 high profile immunology and oncology products ... target the life sciences and diagnostics markets. , ...
... Oct. 26 , 2009 Third Quarter Highlights , ... second quarter 2009 of 9 percent ... Adjusted earnings per share of $0.37 Adjusted EBITDA ... 24 percent and a year-over-year improvement of 7 percent; ...
... NUREMBERG, Germany, October 26 Ziehm ... surgeons in the intra-operative,guidance of pedicle screw and ... Ziehm,s "NaviPort" interface now allows,high-resolution 3D images from ... to,be used for surgical navigation driven by BrainLAB ...
Cached Biology Technology:eBioscience Acquires Bender MedSystems; Business Combination Adds Cutting-Edge Product Lines and Expands International Operations 2eBioscience Acquires Bender MedSystems; Business Combination Adds Cutting-Edge Product Lines and Expands International Operations 3Solutia Reports Third Quarter 2009 Results 2Solutia Reports Third Quarter 2009 Results 3Solutia Reports Third Quarter 2009 Results 4Solutia Reports Third Quarter 2009 Results 5Solutia Reports Third Quarter 2009 Results 6Solutia Reports Third Quarter 2009 Results 7Solutia Reports Third Quarter 2009 Results 8Solutia Reports Third Quarter 2009 Results 9Solutia Reports Third Quarter 2009 Results 10Solutia Reports Third Quarter 2009 Results 11Solutia Reports Third Quarter 2009 Results 12Solutia Reports Third Quarter 2009 Results 13Solutia Reports Third Quarter 2009 Results 14Solutia Reports Third Quarter 2009 Results 15Solutia Reports Third Quarter 2009 Results 16Solutia Reports Third Quarter 2009 Results 17Solutia Reports Third Quarter 2009 Results 18Solutia Reports Third Quarter 2009 Results 19Solutia Reports Third Quarter 2009 Results 20Solutia Reports Third Quarter 2009 Results 21Solutia Reports Third Quarter 2009 Results 22Solutia Reports Third Quarter 2009 Results 23Solutia Reports Third Quarter 2009 Results 24Solutia Reports Third Quarter 2009 Results 25Solutia Reports Third Quarter 2009 Results 26Ziehm Imaging and BrainLAB Improve Trauma and Spine Surgery With X-ray Based Navigation 2Ziehm Imaging and BrainLAB Improve Trauma and Spine Surgery With X-ray Based Navigation 3Ziehm Imaging and BrainLAB Improve Trauma and Spine Surgery With X-ray Based Navigation 4Ziehm Imaging and BrainLAB Improve Trauma and Spine Surgery With X-ray Based Navigation 5
Request Info...
... Highly-purified, endotoxin-free plasmid DNA preparations are ... in quantities from 1mg to multi-gram ... to customer needs, and glycerol stocks ... , Transformation, clonal selection (Clonal selection ...
... plasmid DNA preparations are prepared from ... from 1mg to multi-gram scales. ... (100mg-multi-gram) preparations are made according to ... formulated according to customer needs, and ...
... The QPatch sports 16-independent channels for automated ... used for screening against voltage-gated ion channels, ... as GABA channels. The four pipette ... throughput for ion channel drug discovery. ...
Biology Products: