Navigation Links
Scripps research scientists determine structure of immune molecule that counteracts HIV strains
Date:6/1/2010

LA JOLLA, CA June 1, 2010 In findings that contribute to efforts to design an AIDS vaccine, a team led by Scripps Research Institute scientists has determined the structure of an immune system antibody molecule that effectively acts against most strains of human immunodeficiency virus (HIV), the virus that causes AIDS.

The study, which is being published in an advance, online issue of the journal Proceedings of the National Academy of Sciences (PNAS) during the week of June 1, 2010, illuminates an unusual human antibody called PG16.

"This study advances the overall goal of how to design an HIV vaccine," said Scripps Research Professor Ian Wilson, who led the team with Dennis Burton, Scripps Research professor and scientific director of the International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center at Scripps Research. "This antibody is highly effective in neutralizing HIV-1 and has evolved novel features to combat the virus."

The Problem with HIV

According to the World Health Organization's latest statistics, around 33 million people are living with HIV worldwide. During 2008 alone, more than 2 million men, women, and children succumbed to the disease and an estimated 2.7 million were infected with HIV. One of the most compelling medical challenges today is to develop a vaccine that will provide complete protection to someone who is later exposed to this virus.

HIV causes AIDS by binding to, entering, and ultimately leading to the death of T helper cells, which are immune cells that are necessary to fight off infections by common bacteria and other pathogens. As HIV depletes the body of T helper cells, common pathogens can become potentially lethal.

An effective HIV vaccine would induce antibodies (specialized immune system molecules) against the virus prior to exposure to the virus. Also called immunoglobulins, these antibodies would circulate through the blood, and track down
'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Scripps Research scientists break barrier to creating potential therapeutic molecules
2. Team led by Scripps Research scientists discovers bodys own molecular protection against arthritis
3. American Society for Microbiology to honor Scripps, Claude ZoBell
4. Scripps Research study overturns decade-old findings in neurobiology
5. Scripps research scientists shed light on potential treatment for Gauchers disease
6. Scripps Research team provides groundbreaking new understanding of stem cells
7. New Scripps Research and GNF study helps explain how we can sense temperatures
8. Scripps Research scientists reveal how genetic mutations may cause type 1 diabetes
9. New nano-tool synthesized at Scripps Research Institute
10. Scripps Research scientists solve mystery of fragile stem cells
11. Scripps research team reveals how an old drug could have a new use for treating river blindness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... University Mainz (JGU) as a full member, ensuring ... a significant nationwide standing in the field of ... Gutenberg University Mainz as a full member of ... and international competition for the best minds and ... proud that Mainz University has been recognized as ...
(Date:10/15/2014)...   Neurotechnology , a provider of high-precision ... the VeriLook Surveillance 3.0 software development kit ... face identification using live video streams from single ... version not only identifies faces in a crowd, ... they are moving through the video frame. It ...
(Date:10/14/2014)... is how to produce enough food to feed the ... Agriculture Organization of the United Nations predicts that food ... to feed a growing global population, and plants are ... production. Plants—grains, cereals, fruits, vegetables, and more—feed humans ... must tap into our knowledge of how plants work ...
Breaking Biology News(10 mins):Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 2VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 3Building a bridge from basic botany to applied agriculture 2Building a bridge from basic botany to applied agriculture 3
... Ph.D., of Fred Hutchinson Cancer Research Center, has received ... study the potential role of "genetic conflicts" in the ... colleagues want to find out whether a lost evolutionary ... whether autoimmunity when the body,s immune system turns ...
... PhD candidate has been highly awarded for his innovative image ... Norton, from the Kielpinski group in the Centre for Quantum ... following extensive work on high resolution imaging. Run ... the Extreme Imaging competition aims to promote and celebrate local ...
... French . Vancouver, B.C. -- Marine protected areas ... wrong time. As a result of changing conditions, marine species have been ... per year over the past 50 years, and forecasts of shifts of ... on where to put MPAs weren,t always made with a changing climate ...
Cached Biology News:Did an evolutionary arms race cause lupus? Biologist Harmit Malik receives grant to try and find out 2Extreme imaging wins science praise 2Marine protected areas: changing climate could require change of plans 2
(Date:10/22/2014)... October 22, 2014 Involution Studios ... release of a new infographic, Understanding Ebola . ... a beautifully designed, easy to follow informative tool for ... of outbreak, symptoms and prevention. , "As the news ... the 2014 Ebola outbreak represents not only a healthcare ...
(Date:10/22/2014)... October 22, 2014 According to ... by Service Type (Consulting, Integration, Deployment & Support), ... Deployment Model (Public, Private, Others (Hybrid & Community)) ... defines and segments the Cloud Professional Services Market ... forecasting of revenues. It also identifies the drivers ...
(Date:10/22/2014)... KONG , Oct. 22, 2014  aTyr Pharma ... that rare disease expert John C. McKew , ... McKew brings more than two decades of expertise in ... Institutes of Health, Wyeth Research and Genetics Institute, Inc. ... aTyr,s efforts to expand and translate its novel Physiocrine ...
(Date:10/20/2014)... ON , Oct. 20, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: ... $1.7 million which brings Q3 orders to $5.8 million and provides ... control projects in North America and one ... continue to bid new projects at record levels," said Peter ... were higher at the end of Q3 than they have been ...
Breaking Biology Technology:Involution Studios' Ebola Infographic Provides Key Disease Information and Statistics at a Glance 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 4Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 5aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3
... George Bush and Bill Clinton urge Americans to come to aid ... from two former presidents, but because of how they ask people ... and Clinton point viewers to the Web site for the ... of dollars that have streamed in over the Internet since the ...
... Hamlet: Do you see that cloud, thats almost in shape ... a camel, indeed. ,Hamlet: Methinks it is like a weasel. ... a whale? ,Polonius: Very like a whale. , Hamlet ... Shakespeare) , ,Occasionally stumbling across truth but mostly skilled ...
... Controls unveiled its newest products this week at ... The additions to the line are part of the ... ease of use for customers and branching out into ... showed off its latest vehicular battery, designed for hybrid ...
Cached Biology Technology:Outpouring of tsunami relief displays power of the Internet 2Outpouring of tsunami relief displays power of the Internet 3Follow these three rules when choosing tech consultants 2Follow these three rules when choosing tech consultants 3Follow these three rules when choosing tech consultants 4
Antibody specific for trimethyl-Lys27 of histone H3. Mouse monoclonal. Antigen: Synthetic peptide derived from histone H3, trimethylated at lysine 27...
DL-Dithiothreitol (Clelands Reagent) ,PROTEASE FREE!! ,Molecular Biology Grade ,PRODUCT MUST SHIP NEXT DAY DURING HOT SUMMER MONTHS. ,C 4 H 10 O 2 S 2 ,Molecular Weight: 154.25 ,CAS RN: [27565-...
DTT 50 l...
...
Biology Products: