Navigation Links
Scripps and Complete Genomics to collaborate on genetic research study on healthy aging

MOUNTAIN VIEW and LA JOLLA, Calif. Oct. 3, 2011 Complete Genomics Inc. (NASDAQ: GNOM), the whole human genome sequencing company, and the not-for-profit Scripps Health system today announced a major collaboration that will help further the Wellderly Study, a landmark scientific research initiative aimed at unlocking the genetic secrets of lifelong health.

Under the collaboration, Complete Genomics will sequence, at its own cost, the whole human genomes of 1,000 participants in the Wellderly Study. The Wellderly Study is headed by Scripps Health Chief Academic Officer Dr. Eric J. Topol, who has spent the past four years recruiting healthy elderly individuals who are at least 80 years old and free from major diseases and long-term medications. The median age of this study group is 87, and participants range up to 108 years old.

"There have been a significant number of longevity studies, but the Wellderly Study is the first one focused specifically on healthy aging," said Dr. Topol. "Furthermore, through our partnership with Complete Genomics, we are now conducting the largest whole genome study of a single phenotype healthy lifespan or healthspan. We anticipate that by employing Complete Genomics' sequencing service, and being able to study participants' entire genome for the first time, we will gain valuable insights into the genetic variants that have helped protect the health of our Wellderly population."

The purpose of the Wellderly Study is twofold. First, it is to uncover the genetic underpinnings of healthy life span, which likely involve guardian genes that protect against chronic diseases. Second, healthy older individuals are ideal controls for genetic studies of late-onset diseases such as various cancers, heart disease, Alzheimer's disease and Parkinson's disease.

In addition to sequencing the whole genomes of these 1,000 Wellderly Study participants, Complete Genomics will work with Scripps to assemble the results into a Wellderly Genomic Reference Resource, which may have broad applicability in the field of translational medicine.

"This resource of universal controls will be extremely valuable to other research groups that are using sequencing to understand the genomic root causes of diseases," said Dr. Nicholas Schork, director of research of the Scripps Translational Science Institute (STSI). STSI is a major research initiative of Scripps Health, in collaboration with The Scripps Research Institute.

This study is now possible because the cost of whole human genome sequencing has decreased dramatically over the past few years, while the accuracy and efficiency of the technology has continued to increase. For example, it cost $3 billion to sequence the first human genome via the Human Genome Project in 2000. Just two years ago, Complete Genomics was charging $20,000 to sequence a human genome, and that price is now reduced to $5,000 apiece for small orders and $4,000 each in volume.

Dr. Clifford Reid, the CEO of Complete Genomics, added, "What could be more exciting than to be working with Dr. Topol and his colleagues at Scripps to discover what makes people healthy into their 80s and beyond? Now that Complete Genomics has made whole human genome sequencing affordable, accurate and scalable, we have the opportunity to uncover what's special in the genetic makeup of this extraordinarily healthy group of individuals."

Another valuable aspect of the Reference Resource will be the addition of Cypher Genomics clinical annotations to the sequencing datasets. Cypher Genomics is a project headed by Drs. Schork and Topol, as well as STSI faculty member Dr. Ali Torkamani and STSI industry liaison Dr. Ashley Van Zeeland. STSI has developed and plans to commercialize this software suite for annotating genomic variant lists with clinically relevant pathway and disease prediction information.

"The addition of Cypher Genomics annotations to the Reference Resource will provide researchers with a significant head start when they are looking to identify specific mutations that either cause or, in some cases, prevent the onset of specific diseases," said Dr. Torkamani, director of drug discovery at STSI.

The Wellderly Genomic Reference Resource, which will contain sequence data, variant lists and clinical annotations from more than 1,000 individuals, will be available exclusively from Complete Genomics.


Contact: Steve Carpowich
Scripps Health

Related biology news :

1. 2 Scripps Research scientists win prestigious NIH Innovator Awards
2. Scripps Research team overcomes major obstacle for stem cell therapies and research
3. Scripps Research scientists pinpoint shape-shifting mechanism critical to protein signaling
4. Scripps Research scientists establish new class of anti-diabetic compound
5. Scripps Research scientists produce first stem cells from endangered species
6. Scripps Research scientists help pinpoint cause of stress-related DNA damage
7. Scripps Research scientists expand knowledge of cell process involved in many diseases
8. Scripps Research scientists create vaccine against heroin high
9. Scripps Research scientists solve mystery of nerve disease genes
10. Scripps awarded $7.9 million NIH grant for research to find root cause of heart attack
11. Scripps study finds plastic in 9 percent of garbage patch fishes
Post Your Comments:
(Date:11/17/2015)... Mass. , Nov. 17, 2015 Pressure ... leader in the development and sale of broadly enabling, ... worldwide life sciences industry, today announced it has received ... its $5 million Private Placement (the "Offering"), increasing the ... $4,025,000.  One or more additional closings are expected in ...
(Date:11/11/2015)... 11, 2015   MedNet Solutions , an innovative SaaS-based ... research, is pleased to announce that it will be a ... event, to be held November 17-19 in ... live demonstrations of iMedNet , MedNet,s easy-to-use, ... iMedNet has been able to deliver time and cost ...
(Date:11/4/2015)... , November 4, 2015 ... new market report published by Transparency Market Research "Home Security ... Trends and Forecast 2015 - 2022", the global home security ... 30.3 bn by 2022. The market is estimated to ... period from 2015 to 2022. Rising security needs among ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... LUMPUR, Malaysia , Nov. 24, 2015 /PRNewswire/ ... global contract research organisation (CRO) market. The trend ... result in lower margins but higher volume share ... increased capacity and scale, however, margins in the ... Research Organisation (CRO) Market ( ), ...
(Date:11/24/2015)... 2015 /CNW/ - iCo Therapeutics ("iCo" or "the Company") ... for the quarter ended September 30, 2015. Amounts, ... and presented under International Financial Reporting Standards ("IFRS"). ... said Andrew Rae , President & CEO ... not only value enriching for this clinical program, ...
(Date:11/24/2015)... 2015  Clintrax Global, Inc., a worldwide provider of clinical research ... announced that the company has set a new quarterly earnings record ... quarter growth posted for Q3 of 2014 to Q3 of 2015. ... Mexico , with the establishment of an Asia-Pacific ... United Kingdom and Mexico ...
(Date:11/24/2015)... Massachusetts , November 24, 2015 SHPG ... will participate in the Piper Jaffray 27 th Annual Healthcare ... Tuesday, December 1, 2015, at 8:30 a.m. EST (1:30 p.m. GMT). ... , Chief Financial Officer, will participate in the Piper Jaffray 27 ... , NY on Tuesday, December 1, 2015, at 8:30 a.m. ...
Breaking Biology Technology: